June 2015 - 12 articles
We present the open-source software framework in JModelica.org for numerically solving large-scale dynamic optimization problems. The framework solves problems whose dynamic systems are described in Modelica, an open modeling language supported by se...
Meeting rapidly growing global energy demand—without producing greenhouse gases or further diminishing the availability of non-renewable resources—requires the development of affordable low-emission renewable energy systems. Here, we develop a hybrid...
Valve stiction is indicated as one of the main problems affecting control loop performance and then product quality. Therefore, it is important to detect this phenomenon as early as possible, distinguish it from other causes, and suggest the correct...
This paper deals with the freeze-drying process and, in particular, with the optimization of the operating conditions of the primary drying stage. When designing a freeze-drying cycle, process control aims at obtaining the values of the operating con...
The purpose of this study was to introduce dielectric spectroscopy and biocalorimetry as monitoring methods to follow immobilised Chinese Hamster Ovary (CHO) cell culture development. The theory behind both monitoring techniques is explained and perf...
Continuous pharmaceutical manufacturing together with PAT (Process Analytical Technology) provides a suitable platform for automatic control of the end product quality as desired by QbD (quality by design)-based efficient manufacturing. The precise...
Performing experiments for system identification is often a time-consuming task which may also interfere with the process operation. With memory prices going down and the possibility of cloud storage, years of data is more and more commonly stored (w...
Atoms and molecules assemble into materials, with the material structure determining the properties and ultimate function. Human-made materials and systems have achieved great complexity, such as the integrated circuit and the modern airplane. Howeve...
The fate choice of human embryonic stem cells (hESCs) is controlled by complex signaling milieu synthesized by diverse chemical factors in the growth media. Prevalence of crosstalks and interactions between parallel pathways renders any analysis prob...
The return on investment within the pharmaceutical industry has exhibited an exponential decline over the last several decades. Contemporary analysis suggests that the rate-limiting step associated with the drug discovery and development process is o...
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