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A Combined Feed-Forward/Feed-Back Control System for a QbD-Based Continuous Tablet Manufacturing Process

Engineering Research Center for Structured Organic Particulate Systems (C-SOPS), Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
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Academic Editor: Michael Henson
Processes 2015, 3(2), 339-356; https://doi.org/10.3390/pr3020339
Received: 10 December 2014 / Revised: 20 March 2015 / Accepted: 20 April 2015 / Published: 6 May 2015
Continuous pharmaceutical manufacturing together with PAT (Process Analytical Technology) provides a suitable platform for automatic control of the end product quality as desired by QbD (quality by design)-based efficient manufacturing. The precise control of the quality of the pharmaceutical product requires corrective actions in the process/raw material variability before product quality can be influenced. In this manuscript, a combined feed-forward/feed-back control system has been developed for a direct compaction continuous tablet manufacturing process. The feed-forward controller takes into account the effect of process disturbances proactively while the feed-back control system ensures the end product quality consistently. The coupled feed-forward/feed-back control system ensures the minimum variability in the final product quality irrespective of process and raw material variations. The performance of the combined control strategy has been evaluated through process simulation and is found to be more effective in comparison with a feed-back only control strategy and, therefore, demonstrates potential to further improve pharmaceutical tablet manufacturing operations. View Full-Text
Keywords: feed-forward control; feed-back control; pharmaceutical; manufacturing; QbD; PAT feed-forward control; feed-back control; pharmaceutical; manufacturing; QbD; PAT
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Singh, R.; Muzzio, F.J.; Ierapetritou, M.; Ramachandran, R. A Combined Feed-Forward/Feed-Back Control System for a QbD-Based Continuous Tablet Manufacturing Process. Processes 2015, 3, 339-356.

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