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Open AccessArticle

Identification of Antimicrobial Compounds from Sandwithia guyanensis-Associated Endophyte Using Molecular Network Approach

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Paris-Saclay CNRS ICSN, Institut de Chimie des Substances Naturelles UPR 2301, Université Paris Saclay, 91198 Gif-sur-Yvette, France
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Museum National d’Histoire Naturelle, Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 CNRS/MNHN, Sorbonne Université, Paris CEDEX 05, 75006 Paris, France
*
Author to whom correspondence should be addressed.
Plants 2020, 9(1), 47; https://doi.org/10.3390/plants9010047
Received: 4 December 2019 / Revised: 19 December 2019 / Accepted: 23 December 2019 / Published: 29 December 2019
(This article belongs to the Special Issue Antimicrobial Compounds in Plants)
The emergence of multidrug resistant bacterial pathogens and the increase of antimicrobial resistance constitutes a major health challenge, leading to intense research efforts being focused on the discovery of novel antimicrobial compounds. In this study, endophytes were isolated from different parts of Sandwithia guyanensis plant (leaves, wood and latex) belonging to the Euphorbiaceae family and known to produce antimicrobial compounds, and chemically characterised using Molecular Network in order to discover novel antimicrobial molecules. One fungal endophyte extract obtained from S. guyanensis latex showed significant antimicrobial activity with Minimal Inhibitory Concentration on methicillin-resistant Staphylococcus aureus at 16 µg/mL. The chemical investigation of this fungus (Lecanicillium genus) extract led to the isolation of 5 stephensiolides compounds, four of which demonstrated antibacterial activity. Stephensiolide I and G showed the highest antibacterial activity on MRSA with a MIC at 4 and 16 µg/mL respectively. View Full-Text
Keywords: endophytes; latex; Molecular Networking; antimicrobial; stephensiolides; Lecanicillium sp. endophytes; latex; Molecular Networking; antimicrobial; stephensiolides; Lecanicillium sp.
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MDPI and ACS Style

Mai, P.-Y.; Levasseur, M.; Buisson, D.; Touboul, D.; Eparvier, V. Identification of Antimicrobial Compounds from Sandwithia guyanensis-Associated Endophyte Using Molecular Network Approach. Plants 2020, 9, 47.

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