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Biomolecules 2019, 9(2), 40; https://doi.org/10.3390/biom9020040

Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer

1
Department of Surgery, Institute of Oncology, Istanbul University, 34093 Istanbul, Turkey
2
Department of Medical Oncology, Bakırkoy Dr Sadi Konuk Education and Research Hospital, 34147 Istanbul, Turkey
3
Department of Medical Oncology, Institute of Oncology, Istanbul University, 34093 Istanbul, Turkey
4
Department of Health Science Institute, Istanbul Gelisim University, 34310 Istanbul, Turkey
5
Department of Basic Oncology, Institute of Oncology, Istanbul University, 34093 Istanbul, Turkey
6
Department of Medical Oncology, Institute of Oncology, Istanbul University, 34093 Istanbul, Turkey
*
Author to whom correspondence should be addressed.
Received: 15 December 2018 / Revised: 17 January 2019 / Accepted: 18 January 2019 / Published: 24 January 2019
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Abstract

This study was conducted to investigate the serum levels of membrane-bound mucin 2 (MUC2) in breast cancer (BC) patients and the relationship with tumour progression and known prognostic parameters. We enrolled 127 female patients with histopathologically diagnosed BC who did not receive chemotherapy (CT) or radiotherapy. Serum MUC2 levels were measured by the enzyme-linked immunosorbent assay (ELISA) method and compared with those of 40 age and sex-matched healthy controls. Median age of diagnosis was 50 (range: 26–78). Twenty-eight (22%) patients were metastatic and the most frequent site of metastasis was bone (n = 17, 61%). The median serum MUC2 level of BC patients was significantly higher than that of the controls (198 vs. 54 ng/mL, p < 0.001). There was no significant difference between patients and controls according to known disease-related clinicopathological or laboratory parameters (p > 0.05). Serum MUC2 levels were not associated with survival (p = 0.65). Although serum MUC2 levels might have a diagnostic role, their predictive and prognostic role in survival in BC patients was not detected. Serum levels of MUC2 should be investigated for diagnostic or screening purposes on a larger scale. View Full-Text
Keywords: breast cancer; MUC2; serum; diagnostic breast cancer; MUC2; serum; diagnostic
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Bademler, S.; Zirtiloglu, A.; Sari, M.; Ucuncu, M.Z.; Dogru, E.B.; Karabulut, S. Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer. Biomolecules 2019, 9, 40.

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