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Open AccessArticle

Phytogenic Generation of NiO Nanoparticles Using Stevia Leaf Extract and Evaluation of Their In-Vitro Antioxidant and Antimicrobial Properties

1
Department of Physics, Jawaharlal Nehru Technological University, Anantapur, Anantapuramu 515 002, India
2
Department of Physics, Jawaharlal Nehru Technological University, Pulivendula 516 390, India
3
Exercise and Metabolism Research Center, College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua 321004, China
4
Department of Food Science and Technology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea
5
Department of Microbiology, Yogi Vemana University, Kadapa, Andhra Pradesh 516003, India
6
School of Electronics Engineering, Kyungpook National University, Daegu 41566, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2020, 10(1), 89; https://doi.org/10.3390/biom10010089
Received: 28 November 2019 / Revised: 20 December 2019 / Accepted: 22 December 2019 / Published: 6 January 2020
In the present study, economically viable NiO nanoparticles were produced by biogenic preparation using stevia leaf broth and their in-vitro antioxidant and antimicrobial activities were evaluated. The properties of the prepared NiO nanoparticles were confirmed by analytical techniques such as Ultraviolet-Visible (UV-Vis), X-ray diffraction (XRD), FE-SEM, and Fourier transform infrared spectroscopy (FTIR) analyses. Morphological studies using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed that the size of synthesized nanoparticles ranged from 20 to 50 nm, most of which were spherical and few of which were agglomerated. The role of the biological moieties, which reduce and cap the nanoparticles, was studied using FTIR analysis. The prepared nanoparticles strongly inhibited gram-negative bacteria, which is a camper with gram-positive bacteria and fungi. Furthermore, it performs an effective in-vitro activity through α,α-diphenyl-β-picrylhydrazyl (DPPH) reduction. Thus, it can be concluded that the effective and easy green synthesis process used for NiO nanoparticles provides potential antimicrobial agents against multidrug-resistant microbes.
Keywords: stevia broth; biogenic preparation; NiO nanoparticles; antibacterial; anti-oxidant activity stevia broth; biogenic preparation; NiO nanoparticles; antibacterial; anti-oxidant activity
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MDPI and ACS Style

Srihasam, S.; Thyagarajan, K.; Korivi, M.; Lebaka, V.R.; Mallem, S.P.R. Phytogenic Generation of NiO Nanoparticles Using Stevia Leaf Extract and Evaluation of Their In-Vitro Antioxidant and Antimicrobial Properties. Biomolecules 2020, 10, 89.

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