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Open AccessArticle

Electrochemical Sensing Fabricated with Ta2O5 Nanoparticle-Electrochemically Reduced Graphene Oxide Nanocomposite for the Detection of Oxytetracycline

1
School of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China
2
School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, P.O. Box 447, Arusha, Tanzania
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2020, 10(1), 110; https://doi.org/10.3390/biom10010110
Received: 4 December 2019 / Revised: 30 December 2019 / Accepted: 4 January 2020 / Published: 8 January 2020
(This article belongs to the Section Biological Materials)
A novel tantalum pentoxide nanoparticle-electrochemically reduced graphene oxide nanocomposite-modified glassy carbon electrode (Ta2O5-ErGO/GCE) was developed for the detection of oxytetracycline in milk. The composition, structure and morphology of GO, Ta2O5, and Ta2O5-ErGO were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Oxytetracycline electrochemical behavior on the bare GCE, GO/GCE, ErGO/GCE, and Ta2O5-ErGO/GCE was studied by cyclic voltammetry. The voltammetric conditions (including scan rate, pH, deposition potential, and deposition time) were systematically optimized. With the spacious electrochemical active area, the Ta2O5-ErGO/GCE showed a great magnification of the oxidation signal of oxytetracycline, while that of the other electrodes (GCE, GO/GCE, ErGO/GCE) could not reach the same level. Under the optimum conditions, the currents were proportional to the oxytetracycline concentration in the range from 0.2 to 10 μM, and a low detection limit of 0.095 μM (S/N = 3) was detectable. Moreover, the proposed Ta2O5-ErGO/GCE performed practically with satisfactory results. The preparation of Ta2O5-ErGO/GCE in the current work provides a minor outlook of detecting trace oxytetracycline in milk. View Full-Text
Keywords: Ta2O5-ErGO composition; oxytetracycline; modified electrode; electrochemical reduced graphene oxide; voltammetric determination Ta2O5-ErGO composition; oxytetracycline; modified electrode; electrochemical reduced graphene oxide; voltammetric determination
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MDPI and ACS Style

Magesa, F.; Wu, Y.; Dong, S.; Tian, Y.; Li, G.; Vianney, J.M.; Buza, J.; Liu, J.; He, Q. Electrochemical Sensing Fabricated with Ta2O5 Nanoparticle-Electrochemically Reduced Graphene Oxide Nanocomposite for the Detection of Oxytetracycline. Biomolecules 2020, 10, 110.

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