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Scientia Pharmaceutica, Volume 87, Issue 2

2019 June - 7 articles

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Articles (7)

  • Article
  • Open Access
18 Citations
8,355 Views
12 Pages

Evaluation of Natural Extracts in Animal Models of Pain and Inflammation for a Potential Therapy of Hemorrhoidal Disease

  • Dragos Paul Mihai,
  • Oana Cristina Seremet,
  • Georgiana Nitulescu,
  • Maria Ivopol,
  • Ani-Simona Sevastre,
  • Simona Negres,
  • Gabriel Ivopol,
  • George Mihai Nitulescu and
  • Octavian Tudorel Olaru

The aim of this work was to assess the analgesic effect of three Vitis vinifera L. leaf extracts and the anti-inflammatory effect of three gels obtained from Aesculus hippocastanum L. seed extracts using animal models, as a preliminary study for the...

  • Article
  • Open Access
33 Citations
16,989 Views
12 Pages

Mechanism of Action of Mangifera indica Leaves for Anti-Diabetic Activity

  • Dai-Hung Ngo,
  • Dai-Nghiep Ngo,
  • Thi Thanh Nhan Vo and
  • Thanh Sang Vo

Diabetes is a major metabolic disorder whose prevalence is increasing daily. Medicinal plants have played an important role in the prevention and treatment of type 2 diabetes via prophylactic and therapeutic management. In this study, Mangifera Indic...

  • Article
  • Open Access
4 Citations
6,121 Views
19 Pages

Synthesis and Regularities of the Structure–Activity Relationship in a Series of N-Pyridyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides

  • Igor V. Ukrainets,
  • Anna A. Burian,
  • Ganna M. Hamza,
  • Natali I. Voloshchuk,
  • Oxana V. Malchenko,
  • Svitlana V. Shishkina,
  • Lyudmila V. Sidorenko,
  • Kateryna O. Burian and
  • Galina Sim

According to our quantum and chemical calculations 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid imidazolide is theoretically almost as reactive as its 2-carbonyl analog, and it forms the corresponding N-pyridyl-4-methyl-2,2-diox...

  • Article
  • Open Access
5 Citations
4,506 Views
20 Pages

The Crystal Structure of N-(1-Arylethyl)-4-methyl- 2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides as the Factor Determining Biological Activity Thereof

  • Igor V. Ukrainets,
  • Ganna M. Hamza,
  • Anna A. Burian,
  • Natali I. Voloshchuk,
  • Oxana V. Malchenko,
  • Svitlana V. Shishkina,
  • Irina A. Danylova and
  • Galina Sim

In order to detect new structural and biological patterns in a series of hetaryl-3-carboxylic acid derivatives, the optically pure (S)- and (R)-enantiomers of N-(1-arylethyl)-4-methyl- 2,2-dioxo-1H-6,1-benzothiazine-3-carboxamides, their tru...

  • Article
  • Open Access
3 Citations
5,387 Views
16 Pages

In the last decade, high-performance liquid chromatography/tandem mass spectrometry (LC/MS/MS) combined with electrospray ionization (ESI) has been widely used for determining low concentrations of steroids, and derivatization has often been employed...

  • Article
  • Open Access
18 Citations
9,582 Views
12 Pages

The aim of this study was to investigate the acute and subchronic toxicity of a film formulation that combines κ-Carrageenan and konjac glucomannan for soft capsule application. For the acute toxicity study, a dose of 2000 mg/kg body weight (bw...

  • Article
  • Open Access
37 Citations
9,099 Views
14 Pages

Qualitative and Quantitative Analysis of Different Rhodiola rosea Rhizome Extracts by UHPLC-DAD-ESI-MSn

  • Fabian Alperth,
  • Ivana Turek,
  • Sandra Weiss,
  • Dietmar Vogt and
  • Franz Bucar

Rhodiola rosea has been used in folk medicine as ethanolic macerates for a long time. This study aims to provide a quantitative and qualitative analysis and comparison of different ethanolic Rhodiola rosea rhizome macerates (35%, 70%, and 96% v/v) an...

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Sci. Pharm. - ISSN 2218-0532