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Mechanism of Action of Mangifera indica Leaves for Anti-Diabetic Activity

1
Faculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City 820000, Binh Duong province, Vietnam
2
Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City 700000, Vietnam
3
NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2019, 87(2), 13; https://doi.org/10.3390/scipharm87020013
Received: 4 April 2019 / Revised: 27 May 2019 / Accepted: 28 May 2019 / Published: 31 May 2019
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Abstract

Diabetes is a major metabolic disorder whose prevalence is increasing daily. Medicinal plants have played an important role in the prevention and treatment of type 2 diabetes via prophylactic and therapeutic management. In this study, Mangifera Indica leaf (MIL) extract was investigated for its promising anti-diabetic activity via an in vitro model. It was found that MIL extract possessed significant inhibition on alpha-amylase activity up to (51.4 ± 2.7)% at a concentration of 200 µg/mL. Moreover, glucose adsorption capacity of MIL was identified at (2.7 ± 0.19) mM glucose/g extract. Furthermore, the extract caused a significant increase in glucose uptake up to (143 ± 9.3)% in LO-2 liver cells. Notably, MIL extract was effective in scavenging (63.3 ± 2.1)% 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and (71.6 ± 4.3)% 2,2-azinobis-3-ethyl benzothiazoline-6-sulfonic acid (ABTS)+ radicals and inhibiting (66 ± 4.9)% NO production from RAW264.7 cells without any cytotoxicity effects. Accordingly, M. indica leaves are suggested as a promising material for development of hypoglycemic products. View Full-Text
Keywords: herbal plant; alpha-amylase; anti-diabetes; NO production; glucose uptake herbal plant; alpha-amylase; anti-diabetes; NO production; glucose uptake
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Ngo, D.-H.; Ngo, D.-N.; Vo, T.T.N.; Vo, T.S. Mechanism of Action of Mangifera indica Leaves for Anti-Diabetic Activity. Sci. Pharm. 2019, 87, 13.

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