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Mechanism of Action of Mangifera indica Leaves for Anti-Diabetic Activity

Faculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City 820000, Binh Duong province, Vietnam
Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City 700000, Vietnam
NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
Author to whom correspondence should be addressed.
Sci. Pharm. 2019, 87(2), 13;
Received: 4 April 2019 / Revised: 27 May 2019 / Accepted: 28 May 2019 / Published: 31 May 2019
PDF [1159 KB, uploaded 31 May 2019]


Diabetes is a major metabolic disorder whose prevalence is increasing daily. Medicinal plants have played an important role in the prevention and treatment of type 2 diabetes via prophylactic and therapeutic management. In this study, Mangifera Indica leaf (MIL) extract was investigated for its promising anti-diabetic activity via an in vitro model. It was found that MIL extract possessed significant inhibition on alpha-amylase activity up to (51.4 ± 2.7)% at a concentration of 200 µg/mL. Moreover, glucose adsorption capacity of MIL was identified at (2.7 ± 0.19) mM glucose/g extract. Furthermore, the extract caused a significant increase in glucose uptake up to (143 ± 9.3)% in LO-2 liver cells. Notably, MIL extract was effective in scavenging (63.3 ± 2.1)% 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and (71.6 ± 4.3)% 2,2-azinobis-3-ethyl benzothiazoline-6-sulfonic acid (ABTS)+ radicals and inhibiting (66 ± 4.9)% NO production from RAW264.7 cells without any cytotoxicity effects. Accordingly, M. indica leaves are suggested as a promising material for development of hypoglycemic products. View Full-Text
Keywords: herbal plant; alpha-amylase; anti-diabetes; NO production; glucose uptake herbal plant; alpha-amylase; anti-diabetes; NO production; glucose uptake

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Ngo, D.-H.; Ngo, D.-N.; Vo, T.T.N.; Vo, T.S. Mechanism of Action of Mangifera indica Leaves for Anti-Diabetic Activity. Sci. Pharm. 2019, 87, 13.

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