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Diseases, Volume 13, Issue 8

August 2025 - 45 articles

Cover Story: Pancreatic stone protein (PSP) is gaining recognition as a versatile biomarker with applications in areas ranging from critical care to oncology. Rising earlier than C-reactive protein or procalcitonin and less affected by non-infectious inflammation, PSP offers a valuable tool for timely diagnosis and risk stratification. This review integrates the current evidence on PSP in sepsis, intra-abdominal infections, burns, COVID-19, metabolic disorders, and cancer, detailing its pathophysiology, comparative performance, and prognostic power. By bridging molecular insights with clinical data, the article underscores PSP’s potential to enhance early intervention and improve patient outcomes across diverse healthcare settings. View this paper
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Articles (45)

  • Review
  • Open Access
1,108 Views
15 Pages

Considerations for Augmenting Aripiprazole Long-Acting Injectables with Other Antipsychotics: A Mini-Review

  • Jonathan Shaw,
  • Ethan Kim,
  • Emily Ton,
  • Charles Lai,
  • Peter Bota and
  • Tina Allee

21 August 2025

Aripiprazole is a third-generation antipsychotic, approved in 2002, notable for its partial agonism of the Dopamine D2 receptor and lower risk of metabolic and extrapyramidal adverse effects. It is available in a long-acting injectable formulation, w...

  • Article
  • Open Access
2,616 Views
13 Pages

21 August 2025

Background: Evidence linking dietary fiber intake with cancer risk and mortality is equivocal. Objective: We investigated the relationship between dietary fiber intake and all-cause, cancer, and cardiovascular disease (CVD) mortalities in US adults &...

  • Review
  • Open Access
819 Views
15 Pages

Endobiliary Radiofrequency Ablation for Hepato-Biliary Diseases: A Narrative Review

  • Tawfik Khoury,
  • Wisam Sbeit,
  • Andrea Lisotti and
  • Bertrand Napoléon

21 August 2025

Background/Objectives: Malignant biliary diseases still represent a therapeutic challenge given its poor prognosis, and limited response to the available curative treatments. Recently, endobiliary radiofrequency ablation (RFA) has been increasingly r...

  • Review
  • Open Access
1,148 Views
27 Pages

21 August 2025

Cancer is a leading cause of death worldwide, causing about 10 million deaths annually. Obesity contributes to cancer progression by inducing chronic inflammation, immunosuppressive microenvironment, metabolic dysfunction, and therapeutic resistance....

  • Article
  • Open Access
1,355 Views
10 Pages

Cardiovascular Manifestations and Outcomes in Patients with Scrub Typhus Admitted to a Tertiary Care Center in the Coastal Karnataka Region in India

  • Mugula Sudhakar Rao,
  • Jyothi Samanth,
  • Swathi Poojary,
  • Krishnananda Nayak,
  • Shubha Srinivas and
  • Thrupthi Naik

20 August 2025

Introduction: Scrub typhus is a mite-borne infectious disease caused by “Orientia tsutsugamushi”, a bacterium that was formerly classified under the genus Rickettsia. It is transmitted to humans through the bites of infected chigger mites...

  • Article
  • Open Access
514 Views
11 Pages

19 August 2025

Background/Objectives: We aimed to examine the relationship between COVID-19 cases and Public Health Interventions (PHIs), vaccine coverage, and temperature. We compared our findings with those of other studies that used different methodologies, such...

  • Communication
  • Open Access
1,201 Views
10 Pages

19 August 2025

Background: University students are vulnerable to depression due to the transitional nature of their life stage, which often involves increased academic pressures and social changes. This study aims to examine the prevalence, symptoms, and associated...

  • Review
  • Open Access
1,245 Views
22 Pages

19 August 2025

Obesity affects millions of individuals globally, and a deeper understanding of its associated physiological disturbances is essential for addressing key public health concerns. It has been demonstrated that the influenza virus possesses substantial...

  • Article
  • Open Access
692 Views
15 Pages

Anxiety and Depression in Mild and Moderate COPD Patients: An Observational, Cross-Sectional Study in Greece

  • Effimia Kamariotou,
  • Diamantis Chloros,
  • Dionisios Spyratos,
  • Dionisia Michalopoulou,
  • Ioanna Tsiouprou and
  • Lazaros Sichletidis

17 August 2025

Background: In this study, we investigated patients in the early stages of COPD to support the hypothesis that symptoms of anxiety and depression are related to mild and moderate COPD and not only to the chronic complications that accompany severe di...

  • Article
  • Open Access
1 Citations
720 Views
17 Pages

Is There a Role for the Neutrophil-to-Lymphocyte Ratio for Rebleeding and Mortality Risk Prediction in Acute Variceal Bleeding? A Comparative 5-Year Retrospective Study

  • Sergiu Marian Cazacu,
  • Dragos Ovidiu Alexandru,
  • Alexandru Valentin Popescu,
  • Petrica Popa,
  • Ion Rogoveanu and
  • Vlad Florin Iovanescu

16 August 2025

(1) Background: Acute variceal bleeding (AVB) represents an important cause of upper gastrointestinal bleeding (UGIB). Several prognostic scores may be useful for assessing mortality and rebleeding risk, with the Glasgow-Blatchford score (GBS) and Ro...

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Diseases - ISSN 2079-9721Creative Common CC BY license