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Cellular and Molecular Mechanisms of Obesity-Associated Cancer Development and Treatments
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Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Bond Life Sciences Center, University of Missouri, Columbia, MO 65212, USA
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Cellular and Molecular Mechanisms of Obesity-Associated Cancer Development and Treatments

Abstract submission deadline
30 June 2027
Manuscript submission deadline
31 August 2027
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1409

Topic Information

Dear Colleagues,

Obesity is a chronic disease characterized by the abnormal or excessive accumulation of body fat. According to data from the World Health Organization (WHO), more than 1 billion people in the world are obese, including 650 million adults, 340 million adolescents, and 39 million children, which will cause about 167 million people to become ill by 2025. The prevalence of obesity is impacted by many genetic and environmental factors, such as sex, race, physical activity, diet, and socioeconomic status. Obesity is commonly associated with many other metabolic disorders, including type 2 diabetes (T2D), metabolic dysfunction-associated steatotic liver disease (MASLD), cardiovascular diseases (CVDs), and chronic kidney diseases (CKDs). Obesity, together with these metabolic disorders, has been identified to promote most cancer progression, including breast cancer, hepatocellular carcinoma (HCC), pancreatic ductal adenocarcinoma (PDAC), and lung and kidney cancers. Therefore, it is essential to understand the underlying cellular and molecular mechanisms involved in the pathogenesis of obesity-associated cancers and develop new targets for cancer treatment. This Topic, entitled “Cellular and Molecular Mechanisms of Obesity-Associated Cancer Development and Treatments”, aims to provide a comprehensive overview of the most recent advances in this field and explore the underlying mechanisms of obesity-associated cancer development and new treatment targets.

Dr. Ming Yang
Dr. Chunye Zhang
Topic Editors

Keywords

  • obesity
  • cancers
  • cellular mechanisms
  • molecular targets
  • metabolites
  • drugs
  • diagnosis
  • clinical trials

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Cancers
cancers 		4.4 8.8 2009 20.3 Days CHF 2900 Submit
Current Oncology
curroncol 		3.4 4.9 1994 21.5 Days CHF 2200 Submit
Diseases
diseases 		3.0 3.7 2013 22.7 Days CHF 1800 Submit
International Journal of Molecular Sciences
ijms 		4.9 9.0 2000 20.5 Days CHF 2900 Submit
Cells
cells 		5.2 10.5 2012 16 Days CHF 2700 Submit

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Published Papers (1 paper)

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Article
Dysregulated miRNAs Targeting Adiponectin Signaling in Colorectal Cancer
by Momchil Barbolov, Svetla Slavova, Neda Nedeva, Krasimir Ivanov, Nikola Kolev, Katarzyna Komosinska-Vassev, Diana Ivanova, Deyana Vankova and Yoana Kiselova-Kaneva
Int. J. Mol. Sci. 2025, 26(15), 7196; https://doi.org/10.3390/ijms26157196 - 25 Jul 2025
Viewed by 467
Abstract
Dysregulation in miRNA expression has been reported in a variety of tumors, including colorectal cancer (CRC), where adiponectin regulates a number of processes related to tumorigenesis. The aim of this study was to identify a panel of heavily and consistently altered miRNAs in [...] Read more.
Dysregulation in miRNA expression has been reported in a variety of tumors, including colorectal cancer (CRC), where adiponectin regulates a number of processes related to tumorigenesis. The aim of this study was to identify a panel of heavily and consistently altered miRNAs in CRC that affect adiponectin signaling based on bioinformatics analysis and cross-referencing the available literature. Bioinformatics tools were used to analyze publicly available datasets to identify miRNAs targeting the adiponectin pathway that are substantially dysregulated in CRC. In parallel, a comprehensive literature review was conducted to gather and explore existing knowledge on the relationship between CRC, adiponectin signaling, and miRNA dysregulation. Bioinformatics analysis revealed a set of miRNAs that target adiponectin signaling and are consistently altered in CRC. Several candidate miRNAs, including miR-215-5p, miR-340-5p, miR-181a-5p, miR-150-5p, miR-96-5p, miR-19a-3p, and miR-21-5p, were identified as potential key regulators of the adiponectin cascade, while also being systemically dysregulated in CRC. Through gene ontology enrichment analysis, we further elucidated the biological processes and pathways impacted by these miRNAs, providing insight into their contributions to CRC. The literature review did not identify any previously reported shared connection between these miRNAs, adiponectin signaling, and CRC pathogenesis. Full article
(This article belongs to the Topic Cellular and Molecular Mechanisms of Obesity-Associated Cancer Development and Treatments)
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