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Diseases, Volume 13, Issue 1

January 2025 - 24 articles

Cover Story: Acute myeloid leukemia (AML) is the most common form of leukemia in adults, yet survival rates remain low. Additionally, patients with AML often experience relapse and develop resistance to chemotherapy, underscoring the urgent need for new therapeutic strategies. Venetoclax, a BH3 mimetic, was recently approved for AML treatment in combination with azacitidine or cytarabine. However, these regimens still leave room for improvement. To enhance venetoclax’s therapeutic efficacy, researchers are exploring combination drug partners. Valproic acid, a long-established medication primarily used to treat epilepsy, has been found to be a promising candidate. Valproic acid can enhance the anti-AML activity of venetoclax. This approach exemplifies how drug combinations can unlock the previously untapped potential of existing medications. View this paper
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Articles (24)

  • Systematic Review
  • Open Access
1 Citations
2,888 Views
11 Pages

Yaws in Africa: Past, Present and Future

  • Ezekiel K. Vicar,
  • Shirley V. Simpson,
  • Gloria I. Mensah,
  • Kennedy K. Addo and
  • Eric S. Donkor

14 January 2025

Background: Yaws is an infectious, neglected tropical disease that affects the skin of many children and adolescents who live in poor, rural, low-income communities in humid, tropical areas of Africa, Southeast Asia, and the Pacific Islands. Yaws is...

  • Review
  • Open Access
1 Citations
2,873 Views
14 Pages

A Scoping Review of Eosinophilic Pneumonia and Antidepressants: An Association Not to Be Overlooked

  • Jaron Steiner,
  • Leonie Steuernagel,
  • Fotios Drakopanagiotakis,
  • Konstantinos Bonelis and
  • Paschalis Steiropoulos

13 January 2025

Background: Eosinophilic pneumonias denote a rare condition, wherein infiltrating eosinophilic granulocytes accumulate within the lung parenchyma. Although eosinophilic pneumonias may be idiopathic, they are also associated with secondary causes. Mor...

  • Article
  • Open Access
7,128 Views
13 Pages

Prevalence of Vitamin K2 Deficiency and Its Association with Coronary Artery Disease: A Case–Control Study

  • Sameh A. Ahmed,
  • Abdulaziz A. Yar,
  • Anas M. Ghaith,
  • Rayan N. Alahmadi,
  • Faisal A. Almaleki,
  • Hassan S. Alahmadi,
  • Waleed H. Almaramhy,
  • Ahmed M. Alsaedi,
  • Man K. Alraddadi and
  • Hussein M. Ismail

11 January 2025

Background/Objectives: Vitamin K2 analogs are associated with decreased vascular calcification, which may provide protective benefits for individuals with coronary artery disease (CAD) by stimulating anti-calcific proteins like matrix Gla protein and...

  • Article
  • Open Access
2 Citations
1,965 Views
12 Pages

A Survey of the Knowledge, Attitudes and Practices of a Sample of Albanian Medical Students in Relation to Occupational Exposure to Biological Agents

  • Lorenzo Ippoliti,
  • Luca Coppeta,
  • Ersilia Buonomo,
  • Giuseppina Somma,
  • Giuseppe Bizzarro,
  • Cristiana Ferrari,
  • Andrea Mazza,
  • Agostino Paolino,
  • Claudia Salvi and
  • Vittorio Caputi
  • + 2 authors

10 January 2025

(1) Background: Exposure to blood carries the risk of transmission of many infectious diseases. Healthcare workers (HCWs), including hospital-based medical students, face high and often under-reported rates of exposure to needlestick and sharps injur...

  • Article
  • Open Access
1 Citations
2,008 Views
13 Pages

Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia

  • Renshi Kawakatsu,
  • Kenjiro Tadagaki,
  • Kenta Yamasaki,
  • Yasumichi Kuwahara and
  • Tatsushi Yoshida

8 January 2025

Background: Acute myeloid leukemia (AML) is a common and aggressive form of leukemia, yet current treatment strategies remain insufficient. Venetoclax, a BH3-mimetic approved for AML treatment, induces Bcl-2-dependent apoptosis, though its therapeuti...

  • Article
  • Open Access
1 Citations
2,081 Views
13 Pages

Robotic Surgery from a Gynaecological Oncology Perspective: A Global Gynaecological Oncology Surgical Outcomes Collaborative Led Study (GO SOAR3)

  • Faiza Gaba,
  • Karen Ash,
  • Oleg Blyuss,
  • Dhivya Chandrasekaran,
  • Marielle Nobbenhuis,
  • Thomas Ind,
  • Elly Brockbank and
  • on behalf of the GO SOAR Collaborators

6 January 2025

Background/Objectives: For healthcare institutions developing a robotic programme, delivering value for patients, clinicians, and payers is key. However, the impact on the surgeon, training pathways, and logistics are often overlooked. We conducted a...

  • Article
  • Open Access
1 Citations
1,504 Views
14 Pages

Is Lung Disease a Risk Factor for Sudden Cardiac Death? A Comparative Case–Control Histopathological Study

  • Ioana Radu,
  • Anca Otilia Farcas,
  • Septimiu Voidazan,
  • Carmen Corina Radu and
  • Klara Brinzaniuc

6 January 2025

Background/Objectives: Sudden cardiac death (SCD) constitutes approximately 50% of cardiovascular mortality. Numerous studies have established an interrelation and a strong association between SCD and pulmonary diseases, such as chronic obstructive p...

  • Hypothesis
  • Open Access
6 Citations
2,249 Views
19 Pages

Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones

  • Takanobu Takata,
  • Shinya Inoue,
  • Kenshiro Kunii,
  • Togen Masauji,
  • Junji Moriya,
  • Yoshiharu Motoo and
  • Katsuhito Miyazawa

2 January 2025

Background: Urinary stones (urolithiasis) have been categorized as kidney stones (renal calculus), ureteric stones (ureteral calculus and ureterolith), bladder stones (bladder calculus), and urethral stones (urethral calculus); however, the mechanism...

  • Review
  • Open Access
1,990 Views
19 Pages

1 January 2025

Over the last two decades, the field of microRNA (miRNA) research has grown significantly. MiRNAs are a class of short, single-stranded, non-coding RNAs that regulate gene expression post-transcriptionally. Thereby, miRNAs regulate various essential...

  • Article
  • Open Access
3 Citations
3,750 Views
12 Pages

A Systematic Review and Meta-Analysis of Prophylactic Vasopressors for the Prevention of Peri-Intubation Hypotension

  • Hollie Saunders,
  • Subekshya Khadka,
  • Rabi Shrestha,
  • Hassan Z. Baig and
  • Scott A. Helgeson

31 December 2024

Background/Objectives: Peri-intubation hypotension is a known complication of endotracheal intubation. In the hospital setting, peri-intubation hypotension has been shown to increase hospital mortality and length of stay. The use of prophylactic vaso...

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Diseases - ISSN 2079-9721