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The Anti-Aging Potential of Extracts from Chaenomeles sinensis

Research and Development Department, Club Cosmetics Co., Ltd., Nara 630-0222, Japan
Author to whom correspondence should be addressed.
Cosmetics 2019, 6(1), 21;
Received: 21 February 2019 / Revised: 6 March 2019 / Accepted: 14 March 2019 / Published: 18 March 2019
(This article belongs to the Special Issue Skin Aging)
PDF [2248 KB, uploaded 18 March 2019]


The Chaenomeles sinensis fruit is used as an effective antitussive agent, analgesic, and diuretic in traditional Chinese medicine. It has been reported that C. sinensis fruit extracts have antimicrobial and anti-inflammatory effects. However, there are very few reports about the effects of C. sinensis extracts on skin. In this study, we investigated the effect of C. sinensis extracts on skin aging. The results of in vitro assays showed that whole fruit extracts of C. sinensis had superoxide dismutase (SOD)-like activity and inhibited the activity of dermal extracellular matrix proteases: Elastase and collagenase. The inhibitory effect of the whole fruit (containing seeds) extract on elastase activity was higher than that of the sarcocarp (seeds removed) extract. Further, the sarcocarp extract showed a higher level of SOD-like activity and a greater inhibitory effect on collagenase activity than the whole fruit extract. In particular, among the three activities studied, the sarcocarp extract showed the most significant inhibitory effect on collagenase activity at low concentrations. The polyphenol-rich fraction obtained from the sarcocarp showed significant collagenase inhibition. Based on these results, we concluded that phenolic compounds from C. sinensis sarcocarp have the potential to protect against skin aging through anti-collagenase activity. View Full-Text
Keywords: collagenase inhibition; polyphenol; Chaenomels sinensis collagenase inhibition; polyphenol; Chaenomels sinensis

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Itoh, S.; Yamaguchi, M.; Shigeyama, K.; Sakaguchi, I. The Anti-Aging Potential of Extracts from Chaenomeles sinensis. Cosmetics 2019, 6, 21.

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