Next Article in Journal
Iron Gall Ink Revisited: Natural Formulation for Black Hair-Dyeing
Next Article in Special Issue
Identification of Potential Skin Sensitizers in Myrrh
Previous Article in Journal
The Anti-Aging Potential of Extracts from Chaenomeles sinensis
Open AccessArticle

Sensitization to Fragrance mix-1 in Patients with Contact Dermatitis in Nord-East of Italy: 1996–2016 Time Trend and Gender Effect

Clinical Unit of Occupational Medicine, 32124 Trieste, Italy
*
Author to whom correspondence should be addressed.
Cosmetics 2019, 6(2), 22; https://doi.org/10.3390/cosmetics6020022
Received: 13 February 2019 / Revised: 7 March 2019 / Accepted: 15 March 2019 / Published: 27 March 2019
(This article belongs to the Special Issue Cosmetics Contact Allergens)
(1) Background: Fragrance sensitization is common in Italy and their constituents are used in many cosmetics and detergents. The objective of the study was to analyze the temporal trend of sensitivity to fragrance mix-1 in northeastern Italy and to evaluate gender differences; (2) Methods: From 1996 to 2016, 27,381 consecutive patients with suspected allergic contact dermatitis were patch tested. Individual characteristics were collected through a standardized questionnaire in six departments of dermatology or occupational medicine; (3) Results: The overall prevalence of sensitization to fragrance mix-1 was 7.3%; the prevalence was significantly higher in women (7.7%) than in men (6.3%). From 1996 to 2016, we observed an increase of this sensitization, ranging from 6.2% to 7.7% in males and from 7.2% to 9.1% in females; (4) Conclusions: Our study showed that contact allergy to fragrance mix-1 is important in both sexes and prevalence is increasing over time, despite the introduction of new fragrances with lower sensitization potential. There is the need to reduce the use of fragrances mix-1 to stop the increase of sensitization in exposed subjects. View Full-Text
Keywords: fragrance mix-1; patch test; epidemiology; allergic contact dermatitis; gender fragrance mix-1; patch test; epidemiology; allergic contact dermatitis; gender
Show Figures

Figure 1

MDPI and ACS Style

Larese Filon, F.; Mauro, M. Sensitization to Fragrance mix-1 in Patients with Contact Dermatitis in Nord-East of Italy: 1996–2016 Time Trend and Gender Effect. Cosmetics 2019, 6, 22.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop