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Article

Investigation of the Long-Term Antibacterial Properties of Titanium by Two-Step Micro-Arc Oxidation Treatment

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Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan
2
Research Center for Structural Materials, National Institute for Materials Science (NIMS), 1-2-1 Sengen, Ibaraki, Tsukuba 305-0047, Japan
3
Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
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Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo, Tokyo 113-8510, Japan
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Center for Advanced Medical Engineering Research and Development, Kobe University, 1-5-1 Minatojimaminamimachi, Chuoku, Hyogo, Kobe 650-0047, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Gabriela Ciobanu
Coatings 2021, 11(7), 798; https://doi.org/10.3390/coatings11070798
Received: 8 June 2021 / Revised: 29 June 2021 / Accepted: 29 June 2021 / Published: 1 July 2021
(This article belongs to the Special Issue Multifunctional Coatings on Medical Devices)
Recently, biofilm formation caused by bacterial adhesion and colonization has been recognized as the major cause of failure in orthopedic and dental implant surgeries. In this study, a customized micro-arc oxidation (MAO) treatment technique was developed to obtain desirable antibacterial properties on Ti surfaces. The two-step MAO treatment was applied in the fabrication of specimens with Ag and with/without Zn in their surface oxide layer. In order to simulate practical usage, surface analyses and immersion tests were performed to evaluate the incorporation of Ag and Zn into the resulting oxide layer and ion release behavior, respectively. Additionally, the antibacterial properties of the specimens after long-term immersion in physiological saline were evaluated using Gram-negative facultative anaerobic bacteria. The MAO-treated specimens containing Ag and Zn exhibited excellent antibacterial properties against Escherichia coli, which were sustained even after 6 months of immersion in physiological saline to simulate practical usage. Moreover, the Ag ions released from the surface oxide indicate the antibacterial properties of the specimen in the early stage, while the release of the corrosion products of Zn demonstrates its antibacterial properties in the later stage. View Full-Text
Keywords: titanium; antibacterial property; micro-arc oxidation; Escherichia coli; silver; zinc titanium; antibacterial property; micro-arc oxidation; Escherichia coli; silver; zinc
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MDPI and ACS Style

Tsutsumi, H.; Tsutsumi, Y.; Shimabukuro, M.; Manaka, T.; Chen, P.; Ashida, M.; Ishikawa, K.; Katayama, H.; Hanawa, T. Investigation of the Long-Term Antibacterial Properties of Titanium by Two-Step Micro-Arc Oxidation Treatment. Coatings 2021, 11, 798. https://doi.org/10.3390/coatings11070798

AMA Style

Tsutsumi H, Tsutsumi Y, Shimabukuro M, Manaka T, Chen P, Ashida M, Ishikawa K, Katayama H, Hanawa T. Investigation of the Long-Term Antibacterial Properties of Titanium by Two-Step Micro-Arc Oxidation Treatment. Coatings. 2021; 11(7):798. https://doi.org/10.3390/coatings11070798

Chicago/Turabian Style

Tsutsumi, Harumi, Yusuke Tsutsumi, Masaya Shimabukuro, Tomoyo Manaka, Peng Chen, Maki Ashida, Kunio Ishikawa, Hideki Katayama, and Takao Hanawa. 2021. "Investigation of the Long-Term Antibacterial Properties of Titanium by Two-Step Micro-Arc Oxidation Treatment" Coatings 11, no. 7: 798. https://doi.org/10.3390/coatings11070798

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