Special Issue "Multifunctional Coatings on Medical Devices"

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: 28 February 2021.

Special Issue Editor

Prof. Dr. Gabriela Ciobanu
Website
Guest Editor
Department of Organic, Biochemical and Food Engineering, Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”, “Gheorghe Asachi” Technical University of Iasi, Prof. dr. doc. D. Mangeron Street, no. 73, 700050 Iasi, Romania
Interests: biomaterials (hydroxyapatite, titanium and their alloys, etc.); coatings; scaffolds
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Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to highlighting the important progress achieved in the development of multifunctional coatings on the surface of biomaterials used in medical devices, such as implants, scaffolds for tissue engineering, etc.

It is generally acknowledged that nowadays, a real challenge is the development of biomaterials with new characteristics and properties, for various medical applications. Medical devices are extremely useful in medicine for both diagnostic and therapeutic purposes, being widely used in present day in plastic and reconstructive surgery, dentistry, orthopedics, neurosurgery, cardiovascular surgery, urology, etc.

Multifunctional coatings can give an implantable system certain properties, depending on the function and location of the medical device. Thus, many coatings on implantable devices can promote interactions with adjacent cells and tissue fluids. Also, the surfaces of medical devices can be coated with antibiotic-containing layers able to counteract bacterial adhesion. An interesting approach concerns the development of smart coatings based on biomaterials, which change their properties in response to environmental stimuli. The immobilization of biofunctional molecules and biomolecules on biomaterials to form biofunctional coatings is another challenge for researchers. Many more of outstanding examples could be given.

For this Issue, the following biomaterials are considered, but not limited to: metals (Ti, Mg, etc.) and their alloys, polymers, ceramics, hydroxyapatite.

Potential topics:

The scope of this Special Issue will serve as a forum for papers in the following concepts regarding multifunctional coatings on the surface of the biomaterials used in medical devices, such as implants, scaffolds for tissue engineering, and others:

- Composite coatings;

- Smart coatings;

- Antimicrobial coatings;

- Antifouling coatings;

- Immobilization of biofunctional molecules and biomolecules to form biofunctional coatings;

- Drug delivery coatings.

We kindly invite you to submit your research contribution, namely: research article, communication, or review for this Special Issue.

Prof. Dr. Gabriela Ciobanu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Coating
  • Surface treatment
  • Biomaterial
  • Medical device

Published Papers (3 papers)

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Research

Open AccessEditor’s ChoiceArticle
Rescue Blankets-Transmission and Reflectivity of Electromagnetic Radiation
Coatings 2020, 10(4), 375; https://doi.org/10.3390/coatings10040375 - 10 Apr 2020
Cited by 1
Abstract
Rescue blankets are medical devices made of a polyethylene terephthalate sheet coated with a thin aluminum layer. Blankets are used for protection against hypothermia in prehospital emergency medicine and outdoor sports, but totally different qualities are typical for these multi-functional tools. On the [...] Read more.
Rescue blankets are medical devices made of a polyethylene terephthalate sheet coated with a thin aluminum layer. Blankets are used for protection against hypothermia in prehospital emergency medicine and outdoor sports, but totally different qualities are typical for these multi-functional tools. On the one hand, rescue sheets prevent hypothermia by reducing thermo-convection and diminishing heat loss from evaporation and thermal radiation. On the other hand, the sheets promote cooling by acting as a radiant barrier, by providing shade and even by increasing heat conduction when the sheet is in direct contact with the skin. As foils are watertight and windproof, they can function as vapor barriers and even as stopgap bivouac sacks. We evaluated three experimental studies, one on heat loss by rescue blankets according to surface color, one on transparency with ultraviolet radiation, high-energy visible light and visible light, and one on infrared radiation from rescue blankets. When evaluating the effects of different bands of the electromagnetic spectrum on rescue sheets, we focused on ultraviolet radiation (200–380 nm), high-energy visible light in the violet/blue band (380–450 nm), visible light (380–760 nm) and infrared radiation (7500–13,500 nm). Rescue sheets transmit between 1% and 8% of visible light and about 1% of ultraviolet B radiation (280–315 nm), providing sufficient transparency and adequate protection from snow blindness. Reflection of visible light increases detectability in search and rescue missions performed in good visibility conditions, while reflection of infrared radiation increases detectability in poor visibility conditions and provides protection against hypothermia. Full article
(This article belongs to the Special Issue Multifunctional Coatings on Medical Devices)
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Open AccessEditor’s ChoiceArticle
Layer-by-Layer Deposition of Hyaluronan and Quercetin-Loaded Chitosan Nanoparticles onto Titanium for Improving Blood Compatibility
Coatings 2020, 10(3), 256; https://doi.org/10.3390/coatings10030256 - 09 Mar 2020
Cited by 1
Abstract
Surface modification is an effective way to improve the hemocompatibility of biomaterials. Quercetin has significant anticoagulation and antithrombotic effects, and thus it is a promising candidate agent for the surface modification of blood-contacting materials. In this study, quercetin was successfully encapsulated in tripolyphosphate–chitosan [...] Read more.
Surface modification is an effective way to improve the hemocompatibility of biomaterials. Quercetin has significant anticoagulation and antithrombotic effects, and thus it is a promising candidate agent for the surface modification of blood-contacting materials. In this study, quercetin was successfully encapsulated in tripolyphosphate–chitosan nanoparticles (TCs) based on the ionic gelation of chitosan with tripolyphosphate (TPP) anions. Then, hyaluronan acid (HA)/quercetin-loaded TPP–chitosan nanoparticle (QTCs) films, in addition to HA/TCs films, were prepared separately using an electrostatic layer-by-layer self-assembly technique. The encapsulation of quercetin in the chitosan nanoparticles was confirmed by UV spectra. The quercetin-loaded multilayer coatings were also successfully self-assembled, as confirmed by the UV spectra and contact angle measurements. Platelet adhesion experiments were carried out with platelet-enriched plasma so as to evaluate the blood compatibility of the different samples. There were many platelets on the surfaces of the glass and HA/TC-coated titanium, which were partially activated but not aggregated. Meanwhile, many more platelets were observed on the uncoated titanium surfaces, most of which developed pseudopodia. By contrast, the platelet adhesion and activation were reduced remarkably on the surface of the HA/QTC-coated titanium. These results showed that the multilayer coatings containing quercetin could act as potential biomaterials to improve the anticoagulation performance of blood-contacting materials. Full article
(This article belongs to the Special Issue Multifunctional Coatings on Medical Devices)
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Open AccessFeature PaperEditor’s ChoiceArticle
Electrophoretic Deposition and Characteristics of Chitosan–Nanosilver Composite Coatings on a Nanotubular TiO2 Layer
Coatings 2020, 10(3), 245; https://doi.org/10.3390/coatings10030245 - 06 Mar 2020
Cited by 1
Abstract
The surface treatment of titanium implants has been applied mainly to increase surface bioactivity and, more recently, to introduce antibacterial properties. To this end, composite coatings have been investigated, particularly those based on hydroxyapatite. The present research was aimed at the development of [...] Read more.
The surface treatment of titanium implants has been applied mainly to increase surface bioactivity and, more recently, to introduce antibacterial properties. To this end, composite coatings have been investigated, particularly those based on hydroxyapatite. The present research was aimed at the development of another coating type, chitosan–nanosilver, deposited on a Ti13Zr13Nb alloy. The research comprised characterization of the coating’s microstructure and morphology, time-dependent nanosilver dissolution in simulated body fluid, and investigation of the nanomechanical properties of surface coatings composed of chitosan and nanosilver, with or without a surface-active substance, deposited at different voltages for 1 min on a nanotubular TiO2 layer. The microstructure, morphology, topography, and phase composition were examined, and the silver dissolution rate in simulated body fluid, nanoscale mechanical properties, and water contact angle were measured. The voltage value significantly influenced surface roughness. All specimens possessed high biocompatibility. The highest and best adhesion of the coatings was observed in the absence of a surface-active substance. Silver dissolution caused the appearance of silver ions in solution at levels effective against bacteria and below the upper safe limit value. Full article
(This article belongs to the Special Issue Multifunctional Coatings on Medical Devices)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. Title: Chitosan – nanosilver coatings obtained by electrophoretic deposition on nanotubular TiO2 layer

Authors: Michał Bartmański, Łukasz Pawłowski, Andrzej Zieliński, Aleksandra Mielewczyk-Gryń, Gabriel Strugała, Bartłomiej Cieślik:

Abstract: The chitosan and nanosilver attract an attention for application in medicine as surface coatings as both demonstrate antibacterial efficiency. The crucial problem is to create the coating sufficiently adjacent to the base and possessing long term and high antibacterial efficiency. This research is aimed to obtain more adherent coating by previous formation of nanotubular oxide layer on the Ti-13Zr-13Nb alloy and an addition of polysorbate, possessing antibacterial properties by introducing the nanosilver particles. The effects of presence of polysorbate and voltage value were investigated. The coating microstructure, chemical and phase composition, surface morphology and topography, silver dissolution rate in simulated body fluid, nanomechanical propoerties and contact angle were measured. The voltage value substantially affected surface roughness. The high and best adhesion of the coatings was observed in absence of surface-active substance. All specimens possessed high hydrophility. Silver dissolution caused an appearance of silver ions at contents efficient against bacteria and below the upper safe limit value.

2. Title: Rescue blankets – transmission and reflectivity of electromagnetic radiation

Authors: Hannah Kranebitter1,2, Bernd Wallner3, Andreas Klinger2, Markus Isser2, Franz J. Wiedermann3, Wolfgang Lederer3

Affiliation:

1 Hall County Hospital, Milserstr. 10, 6060 Hall, Austria
2 Medical Division, Austrian Mountain Rescue Service – Tyrol, Florianistr. 2, 6410 Telfs, Austria
3 Medical University of Innsbruck, Department of Anesthesiology and Critical Care Medicine, Anichstr. 35, 6020 Innsbruck, Austria 

Abstract: Rescue blankets are medical devices made of a polyethylene terephthalate sheet coated with a thin aluminum layer. Blankets are used for protection against hypothermia in prehospital emergency medicine and outdoor sports, but converse qualities are typical for these multi-functional tools. On the one hand, rescue sheets prevent hypothermia by reducing thermo-convection and diminishing heat loss from evaporation and thermal radiation. On the other hand, the sheets promote cooling by acting as a radiant barrier, by providing shade and even by increasing heat conduction when the sheet is in direct contact with the skin. As foils are watertight and windproof they can function as vapor barriers and even as stopgap bivouac sacks. When evaluating effects of different bands of the electromagnetic spectrum on rescue sheets we focused on UV radiation (200-380nm), high-energy visible light in the violet/blue band (380-450nm), visible light (380-760nm) and IR radiation (7,500-13,500nm). Rescue sheets transmit between 1% and 8% of visible light and about 1% of UVB radiation, providing sufficient transparency and adequate protection from snow blindness. Reflection of visible light increases detectability in search and rescue missions performed in good visibility conditions, while reflection of IR radiation increases detectability in poor visibility conditions and provides protection against hypothermia.

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