Next Article in Journal
A Morphometric Analysis of Platelet Dense Granules of Patients with Unexplained Bleeding: A New Entity of Delta-Microgranular Storage Pool Deficiency
Next Article in Special Issue
Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients
Previous Article in Journal
Relationship between Insulin Resistance (HOMA-IR), Trabecular Bone Score (TBS), and Three-Dimensional Dual-Energy X-ray Absorptiometry (3D-DXA) in Non-Diabetic Postmenopausal Women
Previous Article in Special Issue
Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea
jcm-logo
Article Menu

Article Menu

Article

A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe

1
Clinical Pharmacology Department, La Paz University Hospital-IdiPAZ, Universidad Autónoma de Madrid, 28046 Madrid, Spain
2
Internal Medicine Department, La Paz University Hospital-IdiPAZ, Universidad Autónoma de Madrid, 28046 Madrid, Spain
3
Pneumology Department, La Paz University Hospital-IdiPAZ, Universidad Autónoma de Madrid, 28046 Madrid, Spain
4
Intensive Care Unit, La Paz University Hospital-IdiPAZ, Universidad Autónoma de Madrid, 28046 Madrid, Spain
5
Emergency Department, La Paz University Hospital-IdiPAZ, Universidad Autónoma de Madrid, 28046 Madrid, Spain
6
Microbiology Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain
7
CSUR Coordination, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain
8
Laboratory Medicine Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain
9
Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA
10
Preventive Medicine Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain
11
Risk Prevention Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain
12
Emergency Radiology Unit, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain
13
Pharmacy Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain
14
Anesthesiology Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain
15
Nursing Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain
16
Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Harvard-MIT Division of Health Sciences and Technology, Boston, MA 02115, USA
*
Authors to whom correspondence should be addressed.
A complete list of the members of the [email protected] Working Group is provided in the Supplementary Materials.
J. Clin. Med. 2020, 9(6), 1733; https://doi.org/10.3390/jcm9061733
Received: 8 May 2020 / Revised: 28 May 2020 / Accepted: 29 May 2020 / Published: 4 June 2020
(This article belongs to the Special Issue COVID-19: From Pathophysiology to Clinical Practice)
Background: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients’ median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes. View Full-Text
Keywords: COVID19; SARS-CoV-2; Spain; Europe COVID19; SARS-CoV-2; Spain; Europe
Show Figures

Figure 1

MDPI and ACS Style

Borobia, A.M.; Carcas, A.J.; Arnalich, F.; Álvarez-Sala, R.; Monserrat-Villatoro, J.; Quintana, M.; Figueira, J.C.; Torres Santos-Olmo, R.M.; García-Rodríguez, J.; Martín-Vega, A.; Buño, A.; Ramírez, E.; Martínez-Alés, G.; García-Arenzana, N.; Núñez, M.C.; Martí-de-Gracia, M.; Moreno Ramos, F.; Reinoso-Barbero, F.; Martin-Quiros, A.; Rivera Núñez, A.; Mingorance, J.; Carpio Segura, C.J.; Prieto Arribas, D.; Rey Cuevas, E.; Prados Sánchez, C.; Rios, J.J.; Hernán, M.A.; Frías, J.; Arribas, J.R.; on behalf of the [email protected] Working Group. A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe. J. Clin. Med. 2020, 9, 1733. https://doi.org/10.3390/jcm9061733

AMA Style

Borobia AM, Carcas AJ, Arnalich F, Álvarez-Sala R, Monserrat-Villatoro J, Quintana M, Figueira JC, Torres Santos-Olmo RM, García-Rodríguez J, Martín-Vega A, Buño A, Ramírez E, Martínez-Alés G, García-Arenzana N, Núñez MC, Martí-de-Gracia M, Moreno Ramos F, Reinoso-Barbero F, Martin-Quiros A, Rivera Núñez A, Mingorance J, Carpio Segura CJ, Prieto Arribas D, Rey Cuevas E, Prados Sánchez C, Rios JJ, Hernán MA, Frías J, Arribas JR, on behalf of the [email protected] Working Group. A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe. Journal of Clinical Medicine. 2020; 9(6):1733. https://doi.org/10.3390/jcm9061733

Chicago/Turabian Style

Borobia, Alberto M., Antonio J. Carcas, Francisco Arnalich, Rodolfo Álvarez-Sala, Jaime Monserrat-Villatoro, Manuel Quintana, Juan C. Figueira, Rosario M. Torres Santos-Olmo, Julio García-Rodríguez, Alberto Martín-Vega, Antonio Buño, Elena Ramírez, Gonzalo Martínez-Alés, Nicolás García-Arenzana, M. C. Núñez, Milagros Martí-de-Gracia, Francisco Moreno Ramos, Francisco Reinoso-Barbero, Alejandro Martin-Quiros, Angélica Rivera Núñez, Jesús Mingorance, Carlos J. Carpio Segura, Daniel Prieto Arribas, Esther Rey Cuevas, Concepción Prados Sánchez, Juan J. Rios, Miguel A. Hernán, Jesús Frías, José R. Arribas, and on behalf of the [email protected] Working Group. 2020. "A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe" Journal of Clinical Medicine 9, no. 6: 1733. https://doi.org/10.3390/jcm9061733

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop