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Journal of Clinical Medicine, Volume 13, Issue 18

2024 September-2 - 311 articles

Cover Story: A penultimate complication of diabetic peripheral neuropathy, diabetic foot infections (DFIs) frequently require emergency medical care often leading to hospital admission and surgical intervention. This nationally representative study used Centers for Disease Control and Prevention (CDC) data across an estimated 2.4 million emergency department (ED) visits in the U.S. with a DFI from 2012 to 2021. DFI cases were generally severe: 43.7% were hospitalized; 83.1% involved anti-infective medications; and 28.1% warranted vancomycin. Multivariable analyses observed that DFIs were associated with 3.002 times higher odds of hospital admissions and a 55.0% longer length of stay. This research may guide future studies to mitigate risk and improve outcomes in the diabetic foot. View this paper
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Articles (311)

  • Article
  • Open Access
3 Citations
1,581 Views
10 Pages

Diabetes-Related Changes in Carotid Wall Properties: Role of Triglycerides

  • Michaela Kozakova,
  • Carmela Morizzo,
  • Giuseppe Penno,
  • Dante Chiappino and
  • Carlo Palombo

23 September 2024

Background/Objectives: This study compares the power of the radiofrequency (RF) signal reflected from the media layer (media power) of the common carotid artery (CCA) and the CCA stiffness between individuals with and without type 2 diabetes mellitus...

  • Review
  • Open Access
9 Citations
4,882 Views
17 Pages

Flexible versus Rigid Bronchoscopy for Tracheobronchial Foreign Body Removal in Children: A Comparative Systematic Review and Meta-Analysis

  • Alaa Safia,
  • Uday Abd Elhadi,
  • Rawnk Bader,
  • Ashraf Khater,
  • Marwan Karam,
  • Taiser Bishara,
  • Saqr Massoud,
  • Shlomo Merchavy and
  • Raed Farhat

23 September 2024

The removal of foreign bodies (FBs) from the airways of children is a critical procedure that can avert serious complications. While both flexible and rigid bronchoscopy techniques are employed for this purpose, their comparative efficacy and safety...

  • Article
  • Open Access
4 Citations
2,565 Views
13 Pages

Treatment of Capsular Contracture in Previously Irradiated Breasts Implants and Expanders with the Use of Porcine Acellular Dermal Matrices: Outcomes and Complications

  • Andrea Vittorio Emanuele Lisa,
  • Riccardo Carbonaro,
  • Manuela Bottoni,
  • Giulia Colombo,
  • Marika Gentilucci,
  • Valeriano Vinci,
  • Edvin Ostapenko,
  • Luca Nicosia,
  • Francesca De Lorenzi and
  • Mario Rietjens

23 September 2024

Background: Radiation therapy is a crucial component of breast cancer treatment. However, it is well known to increase the risk of unsatisfactory cosmetic outcomes and higher complication rates. The aim of this study is to provide further insight int...

  • Article
  • Open Access
1,257 Views
11 Pages

A French Preoperative Cholesteatoma Management: Current Preoperative Consultation and Tendencies

  • Benjamin Reliquet,
  • Mireille Folia,
  • Paul Elhomsy,
  • Serge Aho-Ludwig and
  • Caroline Guigou

23 September 2024

Objectives: This study aimed to characterize the information delivery during preoperative consultations for cholesteatoma removal surgery in 2024. The secondary objective was to identify any factors influencing the information delivered. Methods: Thi...

  • Article
  • Open Access
1 Citations
2,934 Views
15 Pages

Elevated Alanine Transaminase-to-Platelet Index (APRI) Is Associated with Obesity and Distinct Forms of Dyslipidemia: A Retrospective Cross-Sectional Study

  • Yazeed Alshuweishi,
  • Dalal Alfayez,
  • Abdulmalik A. Almufarrih,
  • Arwa Abudawood,
  • Hanan Alyami,
  • Faisal A. Alshuweishi,
  • Yazeed A. Al-Sheikh and
  • Mohammad A. Alfhili

23 September 2024

Background: Obesity is a pathological condition and a major risk factor for dyslipidemia, type 2 diabetes, and non-alcoholic fatty liver disease. Recent research highlighted the association of non-invasive serum markers with these conditions but the...

  • Article
  • Open Access
1,676 Views
12 Pages

The Hedonic Experience Associated with a Gentle Touch Is Preserved in Women with Fibromyalgia

  • Sofia Tagini,
  • Giorgia Varallo,
  • Paolo Capodaglio,
  • Alessandro Mauro and
  • Federica Scarpina

23 September 2024

Background/Objectives: Although manual therapies can be used for pain alleviation in fibromyalgia, there is no clear evidence about the processing of gentle, affective touch in this clinical condition. In fact, persistent painful sensations and psych...

  • Systematic Review
  • Open Access
4 Citations
4,351 Views
12 Pages

The Influence of Obstructive Sleep Apnea on Post-Stroke Complications: A Systematic Review and Meta-Analysis

  • Nithin Kurra,
  • Nikhila Gandrakota,
  • Manju Ramakrishnan,
  • Kavya Sudireddy,
  • Naga Vijaya Lakshmi Divya Boorle and
  • Dinesh Jillella

23 September 2024

Objectives: Evidence shows that obstructive sleep apnea (OSA) is associated with the development of stroke. This study investigates the relationship between OSA and post-stroke complications, addressing the limited data on how OSA influences the seve...

  • Article
  • Open Access
2 Citations
3,593 Views
10 Pages

Association between Hip/Groin Pain and Hip ROM and Strength in Elite Female Soccer Players

  • Eloy Jaenada-Carrilero,
  • Luis Baraja-Vegas,
  • Paula Blanco-Giménez,
  • Raul Gallego-Estevez,
  • Iker J. Bautista and
  • Juan Vicente-Mampel

23 September 2024

Background/Objectives: Hip strength and range of motion have been compared in soccer players with and without hip and groin pain but only in male footballers or gender-combined samples. In female soccer players, the biomechanics contributing to this...

  • Review
  • Open Access
7 Citations
5,780 Views
15 Pages

23 September 2024

In the last three decades, gene therapy has demonstrated significant progress. Over 700 active investigational new drug (IND) applications have been reported. Research on in utero gene therapy has advanced, but ethical and safety concerns persist. A...

  • Article
  • Open Access
1 Citations
1,368 Views
8 Pages

Evaluation of Serum Calprotectin as an Alternative Diagnostic Marker for Intrahepatic Cholestasis of Pregnancy

  • Harshita Katiyar,
  • Sangeeta Yadav,
  • Surender Singh,
  • Ajay Kumar Mishra,
  • Mandakini Pradhan,
  • Raghavendra Lingaiah and
  • Amit Goel

23 September 2024

Background/Objectives: Intrahepatic cholestasis of pregnancy (ICP) is characterised by unexplained intense pruritus during pregnancy. While serum bile acid (BA) is the standard diagnostic marker for ICP, we explored the potential of serum calprotecti...

  • Article
  • Open Access
1 Citations
6,731 Views
8 Pages

23 September 2024

Background: Diagonal earlobe crease (DELC) is a proposed visible predictor of coronary artery disease (CAD). However, studies on the association between atrial fibrillation (AF) and DELC are lacking. This study evaluated the association between DELC...

  • Article
  • Open Access
4 Citations
3,404 Views
12 Pages

Long-Term Results and Quality of Life after Surgery for Acute Aortic Dissection Type A: Contemporary Single-Centre Experience

  • Nora Goebel,
  • Simone A. Holder,
  • Franziska Huether,
  • Eleanor Maw,
  • Rafael Ayala,
  • Yasemin Anguelov,
  • Ulrich F. W. Franke and
  • Dorothee Bail

23 September 2024

Background: Aortic dissection is still afflicted with significant morbidity and mortality. This research seeks to assess long-term outcomes and quality of life after emergency surgery for acute aortic dissection type A. Methods: A total of 413 patien...

  • Case Report
  • Open Access
1 Citations
1,642 Views
9 Pages

Flap-Free Tendon Coverage Using Autologous Fat Grafts Enhanced with Platelet-Rich Plasma and Growth Factors at a Secondary Level Hospital: A Case Report

  • Guadalupe Santamaría Salvador,
  • Esteban Acosta Muñoz,
  • Juan Samaniego Rojas,
  • Charles Hidalgo Quishpe,
  • Juan S. Izquierdo-Condoy,
  • Jorge Vasconez-Gonzalez and
  • Esteban Ortiz-Prado

23 September 2024

Background: Autologous fat grafting, enriched with platelet-rich plasma (PRP), has been established as an effective and affordable treatment for various types of wound healing. However, its efficacy in managing wounds with tendon exposure has not bee...

  • Article
  • Open Access
3 Citations
5,369 Views
13 Pages

Long-Term Follow-Up of the Quality of Life of Endometriosis Patients after Surgery: A Comparative Study

  • Alice Wenzl,
  • Rene Wenzl,
  • Manuela Gstoettner,
  • Lorenz Kuessel,
  • Heinrich Husslein,
  • Jana Heine,
  • Lejla Sandrieser,
  • Christine Bekos and
  • Alexandra Perricos-Hess

23 September 2024

Background/Objectives: This study investigated the long-term effects of the surgical removal of endometriotic lesions on quality of life in endometriosis patients. A sub-analysis explored different subtypes of endometriosis, hormonal influence, and t...

  • Case Report
  • Open Access
1 Citations
2,305 Views
18 Pages

Acupuncture Effect on Reaction-Time Changes in Parkinson’s Disease Patients—Case Study Series

  • Catarina Ramos Pereira,
  • Henry J. Greten,
  • Rubim Santos,
  • Ana Mafalda Reis,
  • Bruno Ramos,
  • Maria João Santos,
  • Jorge Machado and
  • Maria Begoña Criado

23 September 2024

Background: Parkinson’s Disease (PD) is a progressive neurodegenerative condition associated with deficit in reaction time which can lead to falls, resulting in limited independence, diminished quality of life, heightened rates of institutional...

  • Review
  • Open Access
2 Citations
2,536 Views
8 Pages

23 September 2024

Purpose: An innovative eyedrop formulation based on a combination of 0.2% hyaluronic acid and 0.001% hydrocortisone sodium phosphate (Idroflog®, Alfa Intes, Italy; HAC eyedrops) was granted a European Patent in 2016 and has been available on the...

  • Review
  • Open Access
8 Citations
13,500 Views
26 Pages

Pharmacological Treatments of Negative Symptoms in Schizophrenia—An Update

  • Evangelia Maria Tsapakis,
  • Michael Treiber,
  • Calypso Mitkani,
  • Zoe Drakaki,
  • Anastasios Cholevas,
  • Cleanthe Spanaki and
  • Konstantinos N. Fountoulakis

23 September 2024

Schizophrenia is a chronic psychotic disorder comprising positive symptoms, negative symptoms, and cognitive deficits. Negative symptoms are associated with stigma, worse functional outcomes, and a significant deterioration in quality of life. Clinic...

  • Article
  • Open Access
2,232 Views
16 Pages

23 September 2024

Objectives: To assess the impact of topical papaverine administration in complete and incomplete colonic anastomosis, by examining bursting pressure, hydroxyproline concentration, collagen content, inflammation levels, inflammatory cell infiltration,...

  • Article
  • Open Access
2 Citations
2,900 Views
11 Pages

Return to Work Following Anterior Lumbar Interbody Fusion with Percutaneous Posterior Pedicle Fixation: A Retrospective Analysis from Two Academic Centers in Germany

  • Bedjan Behmanesh,
  • Helen Wempe,
  • Fatma Kilinc,
  • Daniel Dubinski,
  • Sae-Yeon Won,
  • Marcus Czabanka,
  • Matthias Setzer,
  • Patrick Schuss,
  • Matthias Schneider and
  • Florian Gessler
  • + 1 author

23 September 2024

Objective: Return to work after spinal surgery is a crucial factor in the recovery process. It can contribute not only to physical rehabilitation but also to psychological well-being. This study aims to evaluate the rate of return to work following e...

  • Article
  • Open Access
2 Citations
3,732 Views
10 Pages

Temporal Pattern of Individual Neurological Function Recovery in Guillain–Barré Syndrome

  • Roopali Mahajan,
  • Jayantee Kalita,
  • Vishal Jha,
  • Nagendra B. Gutti,
  • Prakash C. Pandey and
  • Usha K. Misra

23 September 2024

Background: There is paucity of studies on the temporal pattern of recovery of facial, bulbar, sensory, motor, and autonomic dysfunction in Guillain–Barré syndrome (GBS), although many studies have reported short- and long-term functiona...

  • Article
  • Open Access
1,258 Views
11 Pages

Acromegaly: The Relationship between Hemodynamic Profiles Assessed via Impedance Cardiography and Left Ventricular Systolic Function Assessed via Echocardiography

  • Agnieszka Włochacz,
  • Paweł Krzesiński,
  • Beata Uziębło-Życzkowska,
  • Przemysław Witek,
  • Grzegorz Zieliński,
  • Anna Kazimierczak,
  • Robert Wierzbowski,
  • Małgorzata Banak and
  • Grzegorz Gielerak

23 September 2024

Background/Objectives: Acromegaly-induced prolonged exposure to growth hormone and insulin-like growth factor 1 may have significant cardiovascular effects. The purpose of this study was to assess the relationship between hemodynamic parameters measu...

  • Article
  • Open Access
1 Citations
1,742 Views
12 Pages

23 September 2024

Backgrounds: Kaposi sarcoma (KS) is a unique form of cancer with epidemiological characteristics distinct from those of other solid cancers. While common risk factors including alcohol consumption, smoking, and metabolic disorders have been well stud...

  • Systematic Review
  • Open Access
7 Citations
22,291 Views
20 Pages

23 September 2024

Background: Eye Movement Desensitization and Reprocessing (EMDR) therapy has gained attention for its potential effectiveness in treating depression beyond its initial use for PTSD. This systematic review and meta-analysis aims to evaluate the effica...

  • Article
  • Open Access
3 Citations
2,074 Views
10 Pages

Metformin Treatment Is Not Associated with Altered PD-L1 Expression in Diabetic Patients with Oral Squamous Cell Carcinoma

  • Andreas Mamilos,
  • Lina Winter,
  • Alexander Lein,
  • Steffen Spoerl,
  • Nils Ludwig,
  • Tobias Ettl,
  • Julian Künzel,
  • Torsten Reichert,
  • Gerrit Spanier and
  • Christoph Brochhausen

23 September 2024

Background: The anti-neoplastic activity of metformin is a subject of current debate. Preclinical data have suggested that metformin enhances PD-L1 anti-tumor effects in various cancer entities by decreasing insulin levels and inducing energetic stre...

  • Article
  • Open Access
4 Citations
3,587 Views
14 Pages

Parental Knowledge and Its Impact on Nutrition and Oral Health Habits in Children: A Cognitive Investigation

  • Fabrizio Guerra,
  • Giulia Zumbo,
  • Lucia Straccamore,
  • Laura Sansotta,
  • Claudio Stamegna,
  • Roberta Iacono,
  • Denise Corridore and
  • Iole Vozza

23 September 2024

Background: The correlation between the intake of certain nutrients and the development of oral pathologies has been demonstrated by several studies. The objective of this epidemiological investigation was to evaluate parents’ knowledge and awa...

  • Feature Paper
  • Review
  • Open Access
2,753 Views
13 Pages

23 September 2024

Insomnia is prevalent in primary care and associated with co-morbid physical and mental health conditions and poor health outcomes. While there are effective treatments for insomnia in specialty mental health care, many patients have difficulty acces...

  • Article
  • Open Access
1,654 Views
11 Pages

Allograft Screws as Fixation of the Scarf Osteotomy

  • Kevin Döring,
  • Sebastian Apprich,
  • Markus Hanna,
  • Reinhard Windhager and
  • Stephan Puchner

23 September 2024

Background: In comparison to titanium screws, novel cortical bone allograft screws may come with advantages in osseointegration and with avoidance of potential material removal surgery after scarf osteotomy. Methods: A scarf osteotomy with allograft...

  • Review
  • Open Access
8 Citations
3,888 Views
20 Pages

22 September 2024

The detailed sonographic assessment of the fetal neuroanatomy plays a crucial role in prenatal diagnosis, providing valuable insights into timely, well-coordinated fetal brain development and detecting even subtle anomalies that may impact neurodevel...

  • Review
  • Open Access
13 Citations
7,765 Views
11 Pages

Impact of GLP-1 Receptor Agonists in Gastrointestinal Endoscopy: An Updated Review

  • Sahib Singh,
  • Saurabh Chandan,
  • Dushyant Singh Dahiya,
  • Ganesh Aswath,
  • Daryl Ramai,
  • Marcello Maida,
  • Andrea Anderloni,
  • Nicola Muscatiello and
  • Antonio Facciorusso

22 September 2024

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become one of the most popular medications for patients with diabetes and obesity. Due to their effects on gut motility via central or parasympathetic pathways, there have been concerns about...

  • Article
  • Open Access
2,177 Views
11 Pages

22 September 2024

Background: The main cause of hospitalization in patients with heart failure is hypervolemia. Therefore, the primary treatment strategy involves diuretic therapy using intravenous loop diuretics to achieve decongestion and euvolemia. Some patients wi...

  • Article
  • Open Access
2 Citations
4,543 Views
13 Pages

22 September 2024

Background: There is a growing concern that opioids and benzodiazepines can depress the respiratory drive and could contribute to worsening respiratory failure and higher exacerbation frequency in COPD. However, the relationship between the exacerbat...

  • Article
  • Open Access
2 Citations
2,456 Views
11 Pages

Mechanically Aligned Second-Generation Medial Pivot Primary Total Knee Arthroplasty Does Not Reproduce Normal Knee Biomechanics: A Gait Analysis Study

  • Matteo La Verde,
  • Claudio Belvedere,
  • Eugenio Cammisa,
  • Domenico Alesi,
  • Alberto Fogacci,
  • Maurizio Ortolani,
  • Nicoletta Sileoni,
  • Giada Lullini,
  • Alberto Leardini and
  • Giulio Maria Marcheggiani Muccioli
  • + 1 author

22 September 2024

Background: This study aimed to evaluate post-operative lower limb function following second-generation mechanically aligned medial pivot (MP) TKA implantation. Standard gait analysis was performed to collect kinematic and kinetic data, which were th...

  • Article
  • Open Access
1 Citations
2,428 Views
13 Pages

Clinical and Biochemical Differences in Patients Having Non-Variceal Upper Gastrointestinal Bleeding on NSAIDs, Oral Anticoagulants, and Antiplatelet Therapy

  • Melania Ardelean,
  • Roxana Buzas,
  • Ovidiu Ardelean,
  • Marius Preda,
  • Stelian Ion Morariu,
  • Codrina Mihaela Levai,
  • Ciprian Ilie Rosca,
  • Daniel Florin Lighezan and
  • Nilima Rajpal Kundnani

22 September 2024

Introduction: Upper gastrointestinal bleeding (UGIB) is among the most common causes of morbidity and mortality worldwide, accounting for major resource allocation and increasing incidence. This study aimed to evaluate the severity of non-variceal bl...

  • Editorial
  • Open Access
3 Citations
1,911 Views
3 Pages

Multiple Sclerosis and Demyelinating Disorders: Past, Present, and Future

  • Christos Bakirtzis,
  • Maria Elephteria Evangelopoulos and
  • Nikolaos Grigoriadis

22 September 2024

In the past two decades, there has been a considerable increase of our knowledge with regards to the pathophysiology and management of various demyelinating diseases of the central nervous system [...]

  • Systematic Review
  • Open Access
7 Citations
7,644 Views
18 Pages

22 September 2024

Background: Cannabis use is associated with an increased risk of coronary heart disease (CHD), including angina pectoris (AP), and myocardial infarction (MI). However, it is not clear whether cannabis use is an independent risk factor of AP and/or MI...

  • Article
  • Open Access
2,061 Views
9 Pages

Positive Cutibacterium acnes Intervertebral Discs Are Not Associated with Subsidence Following Anterior Cervical Discectomy and Fusion at 3 or 6 Months

  • Jael Camacho,
  • Jake Carbone,
  • Rohan I. Suresh,
  • Shivam Khanna,
  • Ivan B. Ye,
  • Alexandra E. Thomson,
  • Jacob Bruckner,
  • Rohan Gopinath,
  • Shane McGowan and
  • Steven C. Ludwig
  • + 5 authors

22 September 2024

Background/Objectives: Cutibacterium acnes (C. acnes), formerly known as Propionibacterium acnes (P. acnes), is an anaerobic, low-virulent bacterium that has been associated with postoperative infections of the shoulder, knee, and cervical spine...

  • Article
  • Open Access
2 Citations
1,983 Views
13 Pages

Trends in Hospitalizations of Patients with Hepatitis C Virus in Poland between 2012 and 2022

  • Agnieszka Genowska,
  • Dorota Zarębska-Michaluk,
  • Krystyna Dobrowolska,
  • Krzysztof Kanecki,
  • Paweł Goryński,
  • Piotr Tyszko,
  • Katarzyna Lewtak,
  • Piotr Rzymski and
  • Robert Flisiak

22 September 2024

Background: Analyzing hospitalizations of patients with hepatitis C virus (HCV) infection is essential for an effective action plan to eliminate hepatitis C as a public health threat. This study aimed to explore trends in hospitalizations of patients...

  • Article
  • Open Access
4 Citations
2,283 Views
14 Pages

Optimizing IOL Calculators with Deep Learning Prediction of Total Corneal Astigmatism

  • Avi Wallerstein,
  • Jason Fink,
  • Chirag Shah,
  • Damien Gatinel,
  • Guillaume Debellemanière,
  • Mark Cohen and
  • Mathieu Gauvin

22 September 2024

Background/Objectives: This study aims to identify the most accurate regression model for predicting total corneal astigmatism (TCA) from anterior corneal astigmatism (ACA) and to fine-tune the best model’s architecture to further optimize pred...

  • Article
  • Open Access
2,782 Views
12 Pages

22 September 2024

Background: Low back pain is one of the most prevalent musculoskeletal problems and continues to be the leading cause of disabilities worldwide. The aim of this study was to cross-sectionally investigate the association of physical performance with m...

  • Article
  • Open Access
3 Citations
2,295 Views
17 Pages

Comparison between Substance P and Calcitonin Gene-Related Peptide and Their Receptors in Colorectal Adenocarcinoma

  • Robert-Emmanuel Șerban,
  • Mihail Virgil Boldeanu,
  • Dan Nicolae Florescu,
  • Mihaela Ionescu,
  • Mircea-Sebastian Șerbănescu,
  • Lidia Boldeanu,
  • Mirela-Marinela Florescu,
  • Mioara-Desdemona Stepan,
  • Vasile-Cosmin Obleagă and
  • Cristin Constantin Vere
  • + 3 authors

22 September 2024

Background: Colorectal cancer is a major health problem that still causes many deaths worldwide. Neuropeptides, such as substance P and calcitonin gene-related peptide, play the neurotransmitter and neurohormone roles that increase tumor invasiveness...

  • Article
  • Open Access
3 Citations
3,056 Views
15 Pages

22 September 2024

Background: Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder characterized by significantly elevated levels of low-density lipoprotein (LDL) cholesterol, which plays a major role in the progression of atherosclerosis and l...

  • Case Report
  • Open Access
2 Citations
7,117 Views
10 Pages

22 September 2024

Background: The purpose of this paper is to report the case of a patient who developed a local allergic reaction to the pigment used for permanent eyebrow makeup. In addition, the authors’ protocol for the treatment of such a complication is pr...

  • Article
  • Open Access
1 Citations
2,176 Views
12 Pages

Long-Term Outcomes of Primary Cemented Total Hip Arthroplasty with Acetabular Bone Graft for Protrusio Acetabuli: Minimum 10-Year Follow-Up

  • Liam Z. Yapp,
  • Nick D. Clement,
  • Chloe E. H. Scott,
  • Nathan Ng,
  • Hanna P. Breusch,
  • Deborah J. MacDonald,
  • Paul Gaston and
  • Steffen J. Breusch

21 September 2024

Background: This study reports the long-term survivorship of primary total hip arthroplasty (THA) for protrusio acetabuli. Methods: Patients undergoing THA utilising cement and bone graft acetabular reconstruction for protrusio acetabuli in a univers...

  • Review
  • Open Access
14 Citations
7,631 Views
18 Pages

From Gut to Eye: Exploring the Role of Microbiome Imbalance in Ocular Diseases

  • Andreea-Talida Tîrziu,
  • Monica Susan,
  • Razvan Susan,
  • Tanasescu Sonia,
  • Octavia Oana Harich,
  • Adelina Tudora,
  • Norberth-Istvan Varga,
  • Dragomir Tiberiu-Liviu,
  • Cecilia Roberta Avram and
  • Florin George Horhat
  • + 2 authors

21 September 2024

Background: The gut microbiome plays a crucial role in human health, and recent research has highlighted its potential impact on ocular health through the gut–eye axis. Dysbiosis, or an imbalance in the gut microbiota, has been implicated in va...

  • Article
  • Open Access
6 Citations
5,312 Views
12 Pages

Omalizumab for the Treatment of Chronic Spontaneous Urticaria in Adults and Adolescents: An Eight-Year Real-Life Experience

  • Paolo Calzari,
  • Alessandra Chiei Gallo,
  • Francesca Barei,
  • Eleonora Bono,
  • Massimo Cugno,
  • Angelo Valerio Marzano and
  • Silvia Mariel Ferrucci

21 September 2024

Background: Omalizumab, an anti-IgE monoclonal antibody, is an effective treatment for patients with chronic spontaneous urticaria (CSU) resistant to antihistamines, but about 10% are unresponsive. Our aim was to assess the effectiveness, safety, and...

  • Article
  • Open Access
2,119 Views
10 Pages

21 September 2024

Background: The concurrent presence of chronic hepatitis B virus (CHB) infection and metabolic dysfunction-associated steatotic liver disease (MASLD) presents a unique clinical scenario with implications that are not yet fully understood. This study...

  • Systematic Review
  • Open Access
4 Citations
2,817 Views
20 Pages

Role of Lung Ultrasound in the Detection of Lung Sequelae in Post-COVID-19 Patients: A Systematic Review and Meta-Analysis

  • Andrea Boccatonda,
  • Damiano D’Ardes,
  • Viola Tallarico,
  • Maria Teresa Guagnano,
  • Francesco Cipollone,
  • Cosima Schiavone,
  • Fabio Piscaglia and
  • Carla Serra

21 September 2024

Background: During the COVID-19 pandemic, several studies demonstrated the effectiveness of lung ultrasound (LUS) as a frontline tool in diagnosing and managing acute SARS-CoV-2 pneumonia. However, its role in detecting post-COVID-19 lung sequelae re...

  • Article
  • Open Access
7 Citations
5,751 Views
18 Pages

21 September 2024

Background/Objectives: Managing chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) within the Spanish Sistema Nacional de Salud (SNS) presents significant challenges, particularly due to their high prevalence...

  • Systematic Review
  • Open Access
8 Citations
3,175 Views
22 Pages

21 September 2024

Background/Objectives: Childhood obesity has emerged as a global health concern with profound implications for long-term health outcomes. In recent years, there has been increasing interest in the potential role of environmental factors in the develo...

  • Article
  • Open Access
1,642 Views
8 Pages

Reduced Rate of Anemia after Transcatheter Aortic Valve Replacement

  • Amnon Eitan,
  • Hussein Sliman,
  • Barak Zafrir,
  • Keren Zissman,
  • Moshe Y. Flugelman and
  • Ronen Jaffe

21 September 2024

Background/Objectives: We sought to evaluate changes in hemoglobin level and renal function in patients 5–12 months after transcatheter aortic valve replacement (TAVR), and to examine possible relationships between these changes. Anemia is comm...

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J. Clin. Med. - ISSN 2077-0383