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Gas Vesicle Nanoparticles for Antigen Display

Department of Microbiology and Immunology, Institute of Marine and Environmental Technology, University of Maryland, Baltimore, MD 21202, USA
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Academic Editor: Darrell J. Irvine
Vaccines 2015, 3(3), 686-702; https://doi.org/10.3390/vaccines3030686
Received: 26 June 2015 / Revised: 17 August 2015 / Accepted: 31 August 2015 / Published: 7 September 2015
(This article belongs to the Special Issue Nanoparticle-Based Vaccines)
Microorganisms like the halophilic archaeon Halobacterium sp. NRC-1 produce gas-filled buoyant organelles, which are easily purified as protein nanoparticles (called gas vesicles or GVNPs). GVNPs are non-toxic, exceptionally stable, bioengineerable, and self-adjuvanting. A large gene cluster encoding more than a dozen proteins has been implicated in their biogenesis. One protein, GvpC, found on the exterior surface of the nanoparticles, can accommodate insertions near the C-terminal region and results in GVNPs displaying the inserted sequences on the surface of the nanoparticles. Here, we review the current state of knowledge on GVNP structure and biogenesis as well as available studies on immunogenicity of pathogenic viral, bacterial, and eukaryotic proteins and peptides displayed on the nanoparticles. Recent improvements in genetic tools for bioengineering of GVNPs are discussed, along with future opportunities and challenges for development of vaccines and other applications. View Full-Text
Keywords: protein nanoparticle; adjuvant; carrier; SIV; Chlamydia; Salmonella; typhoid; Plasmodium; malaria; luciferase protein nanoparticle; adjuvant; carrier; SIV; Chlamydia; Salmonella; typhoid; Plasmodium; malaria; luciferase
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DasSarma, S.; DasSarma, P. Gas Vesicle Nanoparticles for Antigen Display. Vaccines 2015, 3, 686-702.

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