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Medical Sciences, Volume 7, Issue 2

February 2019 - 23 articles

Cover Story: Transglutaminase type 2 (TG2) is the most ubiquitously expressed member of the transglutaminase family, which catalyzes specific Ca+2-dependent post-translational modifications of proteins. Since TG2 has been reported as both a potential tumor suppressor and a tumor-promoting factor, its role in cancer is still controversial. The extensive and rapidly growing field in relation to the role of TG2, in several stages of carcinogenesis, cancer stem cells survival, epithelial-mesenchymal transition, and formation of metastatic phenotypes, has produced the conclusion that the physio-pathological effects of TG2 depend on its expression or activities and cellular localization. Indeed, the increased TG2 transamidation activity inhibits tumor cells plasticity and invasion, while its overexpression has been frequently associated with cancer stem cells survival, inflammation, metastatic diffusion, and drug resistance. View Paper here.
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Articles (23)

  • Review
  • Open Access
192 Citations
30,679 Views
21 Pages

Spiritual Care in Palliative Care: A Systematic Review of the Recent European Literature

  • Marie-José H. E. Gijsberts,
  • Anke I. Liefbroer,
  • René Otten and
  • Erik Olsman

7 February 2019

Many studies on spiritual care in palliative care are performed in the US, leaving other continents unexplored. The objective of this systematic review is to map the recent studies on spiritual care in palliative care in Europe. PubMed, CINAHL, ATLA,...

  • Review
  • Open Access
5 Citations
5,102 Views
15 Pages

6 February 2019

Transglutaminase 2 (TG2) is a multifunctional crosslinking enzyme that displays transamidation, protein disulfide isomerase, protein kinase, as well as GTPase and ATPase activities. TG2 can also act as an adhesion molecule involved in the syndecan an...

  • Article
  • Open Access
7 Citations
5,988 Views
13 Pages

Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions

  • Akira Kanda,
  • Kenji Kondo,
  • Naoki Hosaka,
  • Yoshiki Kobayashi,
  • Dan Van Bui,
  • Yasutaka Yun,
  • Kensuke Suzuki,
  • Shunsuke Sawada,
  • Mikiya Asako and
  • Akihiko Nakamura
  • + 7 authors

5 February 2019

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a refractory upper airway disease, accompanied mainly by eosinophilia and/or asthma. In addition, the disease correlates with a high rate of hyposmia, following a marked infiltration of...

  • Review
  • Open Access
14 Citations
6,943 Views
14 Pages

Therapeutic Potential of the Microbiome in the Treatment of Neuropsychiatric Disorders

  • Alper Evrensel,
  • Barış Önen Ünsalver and
  • Mehmet Emin Ceylan

31 January 2019

The search for rational treatment of neuropsychiatric disorders began with the discovery of chlorpromazine in 1951 and continues to evolve. Day by day, new details of the intestinal microbiota–brain axis are coming to light. As the role of micr...

  • Article
  • Open Access
13 Citations
6,426 Views
17 Pages

28 January 2019

The double burden of malnutrition (DBM) and anaemia is a growing concern in developing countries. Using the cross-sectional Bangladesh Demographic Health Survey, 2011, 5763 mother–child pairs were examined. In households where the mother was ov...

  • Article
  • Open Access
43 Citations
5,557 Views
8 Pages

Oxidative Profile of Patients with Sickle Cell Disease

  • Charles Antwi-Boasiako,
  • Gifty B. Dankwah,
  • Robert Aryee,
  • Charles Hayfron-Benjamin,
  • Eric S. Donkor and
  • Andrew D. Campbell

25 January 2019

Oxidative stress plays a very significant role in the pathophysiology of sickle cell disease (SCD) and associated complications. Oxidative stress, which is often experienced by SCD patients as a result of continuous production of reactive oxygen spec...

  • Article
  • Open Access
8 Citations
4,045 Views
9 Pages

25 January 2019

Health-related quality of life (HRQoL) is a multidimensional concept that assesses an individual’s personal satisfaction with his/her daily life while coping with a medical condition and/or its consequent therapy. This study aims to determine t...

  • Feature Paper
  • Review
  • Open Access
50 Citations
7,511 Views
19 Pages

The Role of Tissue Transglutaminase in Cancer Cell Initiation, Survival and Progression

  • Claudio Tabolacci,
  • Angelo De Martino,
  • Carlo Mischiati,
  • Giordana Feriotto and
  • Simone Beninati

25 January 2019

Tissue transglutaminase (transglutaminase type 2; TG2) is the most ubiquitously expressed member of the transglutaminase family (EC 2.3.2.13) that catalyzes specific post-translational modifications of proteins through a calcium-dependent acyl-transf...

  • Article
  • Open Access
10 Citations
7,698 Views
12 Pages

Integrated FISH, Karyotyping and aCGH Analyses for Effective Prenatal Diagnosis of Common Aneuploidies and Other Cytogenomic Abnormalities

  • Hongyan Chai,
  • Autumn DiAdamo,
  • Brittany Grommisch,
  • Jennifer Boyle,
  • Katherine Amato,
  • Dongmei Wang,
  • Jiadi Wen and
  • Peining Li

23 January 2019

Current prenatal genetic evaluation showed a significantly increase in non-invasive screening and the reduction of invasive diagnostic procedures. To evaluate the diagnostic efficacy on detecting common aneuploidies, structural chromosomal rearrangem...

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Med. Sci. - ISSN 2076-3271