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Medical Sciences, Volume 7, Issue 2

2019 February - 23 articles

Cover Story: Transglutaminase type 2 (TG2) is the most ubiquitously expressed member of the transglutaminase family, which catalyzes specific Ca+2-dependent post-translational modifications of proteins. Since TG2 has been reported as both a potential tumor suppressor and a tumor-promoting factor, its role in cancer is still controversial. The extensive and rapidly growing field in relation to the role of TG2, in several stages of carcinogenesis, cancer stem cells survival, epithelial-mesenchymal transition, and formation of metastatic phenotypes, has produced the conclusion that the physio-pathological effects of TG2 depend on its expression or activities and cellular localization. Indeed, the increased TG2 transamidation activity inhibits tumor cells plasticity and invasion, while its overexpression has been frequently associated with cancer stem cells survival, inflammation, metastatic diffusion, and drug resistance. View Paper here.
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Articles (23)

  • Review
  • Open Access
35 Citations
7,432 Views
6 Pages

25 February 2019

There are several mechanisms by which the adenoids contribute to pediatric chronic rhinosinusitis (PCRS), particularly with children aged 12 years and younger. Understanding the role that the adenoids play in PCRS is crucial when attempting to treat...

  • Review
  • Open Access
33 Citations
7,587 Views
13 Pages

Cardiovascular Disease Prevention in Adolescents: eHealth, Co-Creation, and Advocacy

  • Rebecca Raeside,
  • Stephanie R. Partridge,
  • Anna Singleton and
  • Julie Redfern

24 February 2019

Cardiovascular disease (CVD) is the leading cause of death globally. Early atherosclerotic changes can begin to occur early in life and though adolescence. The prevalence of modifiable CVD risk factors, namely, smoking, poor diet quality, excessive a...

  • Review
  • Open Access
28 Citations
4,523 Views
8 Pages

Chronic Rhinosinusitis in Cystic Fibrosis: Diagnosis and Medical Management

  • Chetan Safi,
  • Zhong Zheng,
  • Emily Dimango,
  • Claire Keating and
  • David A. Gudis

22 February 2019

Chronic rhinosinusitis (CRS) is nearly ubiquitous in patients with cystic fibrosis (CF). CF CRS is a challenging entity to define, diagnose, and treat, as patients often have severe refractory sinus disease in addition to complex medical comorbiditie...

  • Review
  • Open Access
18 Citations
7,570 Views
17 Pages

The Use of Probiotic Therapy to Modulate the Gut Microbiota and Dendritic Cell Responses in Inflammatory Bowel Diseases

  • Pablo Alagón Fernández del Campo,
  • Alejandro De Orta Pando,
  • Juan Ignacio Straface,
  • José Ricardo López Vega,
  • Diego Toledo Plata,
  • Sebastian Felipe Niezen Lugo,
  • Diego Alvarez Hernández,
  • Tomás Barrientos Fortes,
  • Laila Gutiérrez-Kobeh and
  • Rosalino Vázquez-López
  • + 1 author

22 February 2019

Recent investigations have shown that different conditions such as diet, the overuse of antibiotics or the colonization of pathogenic microorganisms can alter the population status of the intestinal microbiota. This modification can produce a change...

  • Article
  • Open Access
4 Citations
5,124 Views
10 Pages

Assessment of Cardiovascular Disease Risk and Therapeutic Patterns among Urban Black Rheumatoid Arthritis Patients

  • Isabel M. McFarlane,
  • Su Yien Zhaz Leon,
  • Manjeet S. Bhamra,
  • Aaliya Burza,
  • Stephen Anthony Waite,
  • Milena Rodriguez Alvarez,
  • Kristaq Koci,
  • Nicholas Taklalsingh,
  • Ian Kaplan and
  • Srinivas Kolla
  • + 27 authors

20 February 2019

Rheumatoid arthritis (RA) patients have nearly twice the risk of cardiovascular disease (CVD) compared to the general population. We aimed to assess, in a predominantly Black population, the prevalence of traditional and RA-specific CVD risk factors...

  • Review
  • Open Access
27 Citations
6,016 Views
7 Pages

Chronic Rhinosinusitis: Does Allergy Play a Role?

  • Sonya Marcus,
  • John M. DelGaudio,
  • Lauren T. Roland and
  • Sarah K. Wise

18 February 2019

A few chronic rhinosinusitis (CRS) variants have demonstrated a strong association with environmental allergy, including allergic fungal rhinosinusitis (AFRS) and central compartment atopic disease (CCAD). However, the overall relationship between CR...

  • Article
  • Open Access
57 Citations
9,184 Views
8 Pages

12 February 2019

Self-compassion has shown promise as an adaptive resource for coping with uncertainties and challenges. This study examined the relationship between self-compassion and professional wellbeing (work engagement, exhaustion, and professional life satisf...

  • Review
  • Open Access
43 Citations
9,588 Views
9 Pages

Regulation of Interaction Between the Upper and Lower Airways in United Airway Disease

  • Akira Kanda,
  • Yoshiki Kobayashi,
  • Mikiya Asako,
  • Koichi Tomoda,
  • Hideyuki Kawauchi and
  • Hiroshi Iwai

11 February 2019

The concept of united airway disease comprises allergic rhinitis (AR) with asthma, and eosinophilic chronic rhinosinusitis (ECRS) with asthma. It embodies a comprehensive approach to the treatment of upper and lower airway inflammation. The treatment...

  • Review
  • Open Access
49 Citations
6,219 Views
12 Pages

Identification of Prognostic and Predictive Osteosarcoma Biomarkers

  • Radoslav Zamborsky,
  • Milan Kokavec,
  • Stefan Harsanyi and
  • Lubos Danisovic

11 February 2019

Both adolescents and children suffer from osteosarcoma, localized in the metaphysis of the long bones. This is the most common primary high-grade bone tumor in this patient group. Early tumor detection is the key to ensuring effective treatment. Impr...

  • Brief Report
  • Open Access
4 Citations
4,839 Views
6 Pages

8 February 2019

Bronchopulmonary dysplasia (BPD) is the most common respiratory sequelae of prematurity and histopathologically features fewer, dysmorphic, pulmonary arteries. We present our experience with the digital subtraction pulmonary angiography (DSPA) findin...

  • Review
  • Open Access
202 Citations
31,243 Views
21 Pages

Spiritual Care in Palliative Care: A Systematic Review of the Recent European Literature

  • Marie-José H. E. Gijsberts,
  • Anke I. Liefbroer,
  • René Otten and
  • Erik Olsman

7 February 2019

Many studies on spiritual care in palliative care are performed in the US, leaving other continents unexplored. The objective of this systematic review is to map the recent studies on spiritual care in palliative care in Europe. PubMed, CINAHL, ATLA,...

  • Review
  • Open Access
5 Citations
5,183 Views
15 Pages

6 February 2019

Transglutaminase 2 (TG2) is a multifunctional crosslinking enzyme that displays transamidation, protein disulfide isomerase, protein kinase, as well as GTPase and ATPase activities. TG2 can also act as an adhesion molecule involved in the syndecan an...

  • Article
  • Open Access
7 Citations
6,095 Views
13 Pages

Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions

  • Akira Kanda,
  • Kenji Kondo,
  • Naoki Hosaka,
  • Yoshiki Kobayashi,
  • Dan Van Bui,
  • Yasutaka Yun,
  • Kensuke Suzuki,
  • Shunsuke Sawada,
  • Mikiya Asako and
  • Hiroshi Iwai
  • + 7 authors

5 February 2019

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a refractory upper airway disease, accompanied mainly by eosinophilia and/or asthma. In addition, the disease correlates with a high rate of hyposmia, following a marked infiltration of...

  • Review
  • Open Access
15 Citations
7,017 Views
14 Pages

Therapeutic Potential of the Microbiome in the Treatment of Neuropsychiatric Disorders

  • Alper Evrensel,
  • Barış Önen Ünsalver and
  • Mehmet Emin Ceylan

31 January 2019

The search for rational treatment of neuropsychiatric disorders began with the discovery of chlorpromazine in 1951 and continues to evolve. Day by day, new details of the intestinal microbiota–brain axis are coming to light. As the role of micr...

  • Article
  • Open Access
14 Citations
6,511 Views
17 Pages

28 January 2019

The double burden of malnutrition (DBM) and anaemia is a growing concern in developing countries. Using the cross-sectional Bangladesh Demographic Health Survey, 2011, 5763 mother–child pairs were examined. In households where the mother was ov...

  • Article
  • Open Access
47 Citations
5,819 Views
8 Pages

Oxidative Profile of Patients with Sickle Cell Disease

  • Charles Antwi-Boasiako,
  • Gifty B. Dankwah,
  • Robert Aryee,
  • Charles Hayfron-Benjamin,
  • Eric S. Donkor and
  • Andrew D. Campbell

25 January 2019

Oxidative stress plays a very significant role in the pathophysiology of sickle cell disease (SCD) and associated complications. Oxidative stress, which is often experienced by SCD patients as a result of continuous production of reactive oxygen spec...

  • Article
  • Open Access
8 Citations
4,102 Views
9 Pages

25 January 2019

Health-related quality of life (HRQoL) is a multidimensional concept that assesses an individual’s personal satisfaction with his/her daily life while coping with a medical condition and/or its consequent therapy. This study aims to determine t...

  • Feature Paper
  • Review
  • Open Access
51 Citations
7,596 Views
19 Pages

The Role of Tissue Transglutaminase in Cancer Cell Initiation, Survival and Progression

  • Claudio Tabolacci,
  • Angelo De Martino,
  • Carlo Mischiati,
  • Giordana Feriotto and
  • Simone Beninati

25 January 2019

Tissue transglutaminase (transglutaminase type 2; TG2) is the most ubiquitously expressed member of the transglutaminase family (EC 2.3.2.13) that catalyzes specific post-translational modifications of proteins through a calcium-dependent acyl-transf...

  • Article
  • Open Access
10 Citations
7,900 Views
12 Pages

Integrated FISH, Karyotyping and aCGH Analyses for Effective Prenatal Diagnosis of Common Aneuploidies and Other Cytogenomic Abnormalities

  • Hongyan Chai,
  • Autumn DiAdamo,
  • Brittany Grommisch,
  • Jennifer Boyle,
  • Katherine Amato,
  • Dongmei Wang,
  • Jiadi Wen and
  • Peining Li

23 January 2019

Current prenatal genetic evaluation showed a significantly increase in non-invasive screening and the reduction of invasive diagnostic procedures. To evaluate the diagnostic efficacy on detecting common aneuploidies, structural chromosomal rearrangem...

  • Article
  • Open Access
9 Citations
4,090 Views
17 Pages

22 January 2019

Pregnancy brings about strong cravings for nonfood materials, the gestational toxicities of which are not yet ascertained. In this study, we used rat models to investigate the effect of clay beverage consumption during early and late gestation on p-T...

  • Review
  • Open Access
54 Citations
6,167 Views
14 Pages

22 January 2019

Immune checkpoint inhibitors (ICPis) have revolutionized cancer therapy with broad activities against a wide range of malignancies. However, in many malignancies their efficacy remains limited due to the primary resistance. Furthermore, a high percen...

  • Review
  • Open Access
4 Citations
3,658 Views
9 Pages

22 January 2019

The re-naming of noninvasive follicular variant papillary thyroid cancer to the apparently non-malignant, noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) impacts the prevalence of malignancy rates, thereby affecti...

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Med. Sci. - ISSN 2076-3271