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Medical Sciences, Volume 7, Issue 2

February 2019 - 23 articles

Cover Story: Transglutaminase type 2 (TG2) is the most ubiquitously expressed member of the transglutaminase family, which catalyzes specific Ca+2-dependent post-translational modifications of proteins. Since TG2 has been reported as both a potential tumor suppressor and a tumor-promoting factor, its role in cancer is still controversial. The extensive and rapidly growing field in relation to the role of TG2, in several stages of carcinogenesis, cancer stem cells survival, epithelial-mesenchymal transition, and formation of metastatic phenotypes, has produced the conclusion that the physio-pathological effects of TG2 depend on its expression or activities and cellular localization. Indeed, the increased TG2 transamidation activity inhibits tumor cells plasticity and invasion, while its overexpression has been frequently associated with cancer stem cells survival, inflammation, metastatic diffusion, and drug resistance. View Paper here.
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Articles (23)

  • Review
  • Open Access
35 Citations
7,079 Views
6 Pages

25 February 2019

There are several mechanisms by which the adenoids contribute to pediatric chronic rhinosinusitis (PCRS), particularly with children aged 12 years and younger. Understanding the role that the adenoids play in PCRS is crucial when attempting to treat...

  • Review
  • Open Access
32 Citations
7,479 Views
13 Pages

Cardiovascular Disease Prevention in Adolescents: eHealth, Co-Creation, and Advocacy

  • Rebecca Raeside,
  • Stephanie R. Partridge,
  • Anna Singleton and
  • Julie Redfern

24 February 2019

Cardiovascular disease (CVD) is the leading cause of death globally. Early atherosclerotic changes can begin to occur early in life and though adolescence. The prevalence of modifiable CVD risk factors, namely, smoking, poor diet quality, excessive a...

  • Review
  • Open Access
25 Citations
4,420 Views
8 Pages

Chronic Rhinosinusitis in Cystic Fibrosis: Diagnosis and Medical Management

  • Chetan Safi,
  • Zhong Zheng,
  • Emily Dimango,
  • Claire Keating and
  • David A. Gudis

22 February 2019

Chronic rhinosinusitis (CRS) is nearly ubiquitous in patients with cystic fibrosis (CF). CF CRS is a challenging entity to define, diagnose, and treat, as patients often have severe refractory sinus disease in addition to complex medical comorbiditie...

  • Review
  • Open Access
18 Citations
7,451 Views
17 Pages

The Use of Probiotic Therapy to Modulate the Gut Microbiota and Dendritic Cell Responses in Inflammatory Bowel Diseases

  • Pablo Alagón Fernández del Campo,
  • Alejandro De Orta Pando,
  • Juan Ignacio Straface,
  • José Ricardo López Vega,
  • Diego Toledo Plata,
  • Sebastian Felipe Niezen Lugo,
  • Diego Alvarez Hernández,
  • Tomás Barrientos Fortes,
  • Laila Gutiérrez-Kobeh and
  • Sandra Georgina Solano-Gálvez
  • + 1 author

22 February 2019

Recent investigations have shown that different conditions such as diet, the overuse of antibiotics or the colonization of pathogenic microorganisms can alter the population status of the intestinal microbiota. This modification can produce a change...

  • Article
  • Open Access
4 Citations
5,031 Views
10 Pages

Assessment of Cardiovascular Disease Risk and Therapeutic Patterns among Urban Black Rheumatoid Arthritis Patients

  • Isabel M. McFarlane,
  • Su Yien Zhaz Leon,
  • Manjeet S. Bhamra,
  • Aaliya Burza,
  • Stephen Anthony Waite,
  • Milena Rodriguez Alvarez,
  • Kristaq Koci,
  • Nicholas Taklalsingh,
  • Ian Kaplan and
  • Joshy Pathiparampil
  • + 27 authors

20 February 2019

Rheumatoid arthritis (RA) patients have nearly twice the risk of cardiovascular disease (CVD) compared to the general population. We aimed to assess, in a predominantly Black population, the prevalence of traditional and RA-specific CVD risk factors...

  • Review
  • Open Access
27 Citations
5,716 Views
7 Pages

Chronic Rhinosinusitis: Does Allergy Play a Role?

  • Sonya Marcus,
  • John M. DelGaudio,
  • Lauren T. Roland and
  • Sarah K. Wise

18 February 2019

A few chronic rhinosinusitis (CRS) variants have demonstrated a strong association with environmental allergy, including allergic fungal rhinosinusitis (AFRS) and central compartment atopic disease (CCAD). However, the overall relationship between CR...

  • Article
  • Open Access
54 Citations
9,066 Views
8 Pages

12 February 2019

Self-compassion has shown promise as an adaptive resource for coping with uncertainties and challenges. This study examined the relationship between self-compassion and professional wellbeing (work engagement, exhaustion, and professional life satisf...

  • Review
  • Open Access
40 Citations
9,063 Views
9 Pages

Regulation of Interaction Between the Upper and Lower Airways in United Airway Disease

  • Akira Kanda,
  • Yoshiki Kobayashi,
  • Mikiya Asako,
  • Koichi Tomoda,
  • Hideyuki Kawauchi and
  • Hiroshi Iwai

11 February 2019

The concept of united airway disease comprises allergic rhinitis (AR) with asthma, and eosinophilic chronic rhinosinusitis (ECRS) with asthma. It embodies a comprehensive approach to the treatment of upper and lower airway inflammation. The treatment...

  • Review
  • Open Access
48 Citations
6,109 Views
12 Pages

Identification of Prognostic and Predictive Osteosarcoma Biomarkers

  • Radoslav Zamborsky,
  • Milan Kokavec,
  • Stefan Harsanyi and
  • Lubos Danisovic

11 February 2019

Both adolescents and children suffer from osteosarcoma, localized in the metaphysis of the long bones. This is the most common primary high-grade bone tumor in this patient group. Early tumor detection is the key to ensuring effective treatment. Impr...

  • Brief Report
  • Open Access
4 Citations
4,726 Views
6 Pages

8 February 2019

Bronchopulmonary dysplasia (BPD) is the most common respiratory sequelae of prematurity and histopathologically features fewer, dysmorphic, pulmonary arteries. We present our experience with the digital subtraction pulmonary angiography (DSPA) findin...

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Med. Sci. - ISSN 2076-3271