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Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing

1
University of Minnesota Twin Cities, Department of Medicine, Minneapolis, MN 55455, USA
2
Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, GZ-6, Boston, MA 02215, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Med. Sci. 2019, 7(2), 15; https://doi.org/10.3390/medsci7020015
Received: 15 December 2018 / Revised: 12 January 2019 / Accepted: 18 January 2019 / Published: 22 January 2019
(This article belongs to the Special Issue Thyroid Cytopathology)
The re-naming of noninvasive follicular variant papillary thyroid cancer to the apparently non-malignant, noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) impacts the prevalence of malignancy rates, thereby affecting mutation frequency in papillary thyroid cancer. Preoperative assessment of such nodules could affect management in the future. The original publications following the designation of the new nomenclature have been extensively reviewed. With the adoption of NIFTP terminology, a reduction in the follicular variant of papillary thyroid cancer (FVPTC) prevalence is anticipated, as is a modest reduction of papillary thyroid cancer (PTC) prevalence that would be distributed mainly across indeterminate thyroid nodules. Identifying NIFTP preoperatively remains challenging. RAS mutations are predominant but the presence of BRAF V600E mutation has been observed and could indicate inclusion of the classical PTC. The histological diagnosis of NIFTP to designate low-risk encapsulated follicular variant papillary thyroid cancers (EFVPTCs) would impact malignancy rates, thereby altering the mutation prevalence. The histopathologic criteria have recently been refined with an exclusion of well-formed papillae. The preoperative identification of NIFTP using cytomorphology and gene testing remains challenging. View Full-Text
Keywords: NIFTP; non-invasive follicular thyroid neoplasm with papillary-like nuclear features; Bethesda; FVPTC; follicular variant of Papillary thyroid cancer; RAS; BRAF NIFTP; non-invasive follicular thyroid neoplasm with papillary-like nuclear features; Bethesda; FVPTC; follicular variant of Papillary thyroid cancer; RAS; BRAF
MDPI and ACS Style

Shrestha, R.T.; Ruanpeng, D.; Hennessey, J.V. Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing. Med. Sci. 2019, 7, 15.

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