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Genes, Volume 9, Issue 4

April 2018 - 53 articles

Cover Story: Xenopus laevis is an established model for studying kidney disease and development. Pathways that regulate kidney development and function in humans are conserved in X. laevis. In contrast with mammalian kidneys, the X. laevis embryonic kidney contains one functional nephron, making it a simplified model. The embryos’ external development and transparent epidermis allows for easy visualization of the kidneys. The cdh17:eGFP line enables the visualization of kidney development in living embryos, facilitating high-throughput screening for kidney-disease-causing genes. View this paper
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Articles (53)

  • Article
  • Open Access
18 Citations
5,148 Views
16 Pages

Genome Wide Identification, Evolutionary, and Expression Analysis of VQ Genes from Two Pyrus Species

  • Yunpeng Cao,
  • Dandan Meng,
  • Muhammad Abdullah,
  • Qing Jin,
  • Yi Lin and
  • Yongping Cai

23 April 2018

The VQ motif-containing gene, a member of the plant-specific genes, is involved in the plant developmental process and various stress responses. The VQ motif-containing gene family has been studied in several plants, such as rice (Oryza sativa), maiz...

  • Article
  • Open Access
30 Citations
6,996 Views
24 Pages

23 April 2018

Syntrophic acetate oxidation operates close to the thermodynamic equilibrium and very little is known about the participating organisms and their metabolism. Clostridium ultunense is one of the most abundant syntrophic acetate-oxidising bacteria (SAO...

  • Article
  • Open Access
5 Citations
5,405 Views
15 Pages

Divergent Roles of RPA Homologs of the Model Archaeon Halobacterium salinarum in Survival of DNA Damage

  • Jessica J. Evans,
  • Patrick E. Gygli,
  • Julienne McCaskill and
  • Linda C. DeVeaux

20 April 2018

The haloarchaea are unusual in possessing genes for multiple homologs to the ubiquitous single-stranded DNA binding protein (SSB or replication protein A, RPA) found in all three domains of life. Halobacterium salinarum contains five homologs: two ar...

  • Article
  • Open Access
28 Citations
9,231 Views
14 Pages

19 April 2018

Understanding how species respond to population declines is a central question in conservation and evolutionary biology. Population declines are often associated with loss of genetic diversity, inbreeding and accumulation of deleterious mutations, wh...

  • Article
  • Open Access
10 Citations
4,942 Views
14 Pages

Genome-Wide Analyses of Calcium Sensors Reveal Their Involvement in Drought Stress Response and Storage Roots Deterioration after Harvest in Cassava

  • Wei Hu,
  • Yan Yan,
  • Weiwei Tie,
  • Zehong Ding,
  • Chunlai Wu,
  • Xupo Ding,
  • Wenquan Wang,
  • Zhiqiang Xia,
  • Jianchun Guo and
  • Ming Peng

19 April 2018

Calcium (Ca2+) plays a crucial role in plant development and responses to environmental stimuli. Currently, calmodulins (CaMs), calmodulin-like proteins (CMLs), and calcineurin B-like proteins (CBLs), such as Ca2+ sensors, are not well understood in...

  • Article
  • Open Access
24 Citations
7,977 Views
18 Pages

Accurate Classification of NF1 Gene Variants in 84 Italian Patients with Neurofibromatosis Type 1

  • Alessandro Stella,
  • Patrizia Lastella,
  • Daria Carmela Loconte,
  • Nenad Bukvic,
  • Dora Varvara,
  • Margherita Patruno,
  • Rosanna Bagnulo,
  • Rosaura Lovaglio,
  • Nicola Bartolomeo and
  • Gabriella Serio
  • + 1 author

17 April 2018

Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant genetic diseases. It is caused by mutations in the NF1 gene encoding for the large protein, neurofibromin. Genetic testing of NF1 is cumbersome because 50% of cases are spora...

  • Article
  • Open Access
12 Citations
4,720 Views
17 Pages

17 April 2018

Attempts to uncover the genetic basis of female mating preferences and male signals involved in reproductive isolation have discovered intriguing cases in which loci contributing to these traits co-localize in their chromosomal positions. Such discov...

  • Article
  • Open Access
11 Citations
5,336 Views
16 Pages

17 April 2018

Thuja koraiensis Nakai is an endangered conifer of high economic and ecological value in Jilin Province, China. However, studies on its population structure and conservation genetics have been limited by the lack of genomic data. Here, 37,761 microsa...

  • Article
  • Open Access
64 Citations
11,113 Views
15 Pages

Patchoulol Production with Metabolically Engineered Corynebacterium glutamicum

  • Nadja A. Henke,
  • Julian Wichmann,
  • Thomas Baier,
  • Jonas Frohwitter,
  • Kyle J. Lauersen,
  • Joe M. Risse,
  • Petra Peters-Wendisch,
  • Olaf Kruse and
  • Volker F. Wendisch

17 April 2018

Patchoulol is a sesquiterpene alcohol and an important natural product for the perfume industry. Corynebacterium glutamicum is the prominent host for the fermentative production of amino acids with an average annual production volume of ~6 million to...

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Genes - ISSN 2073-4425Creative Common CC BY license