Table of Contents
Genes, Volume 9, Issue 4 (April 2018)
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Cover Story (view full-size image) Xenopus laevis is an established model for studying kidney disease and development. Pathways that [...] Read more. Xenopus laevis is an established model for studying kidney disease and development. Pathways that regulate kidney development and function in humans are conserved in X. laevis. In contrast with mammalian kidneys, the X. laevis embryonic kidney contains one functional nephron, making it a simplified model. The embryos’ external development and transparent epidermis allows for easy visualization of the kidneys. The cdh17:eGFP line enables the visualization of kidney development in living embryos, facilitating high-throughput screening for kidney-disease-causing genes. View this paper