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Genes, Volume 16, Issue 2

February 2025 - 128 articles

Cover Story: The variants rs10517086 and rs1534422 are predictive of type 1 diabetes mellitus (T1DM) development and poor residual β cell function within the first year of diagnosis. However, the mechanism by which risk is conferred is unknown. Using CRISPR/Cas9, we show that both variants significantly reduce glucose-stimulated insulin secretion, increase the production of pro-inflammatory cytokines, and reduce the expression of several β cell markers and transcription factors. However, much of this appeared to be under the control of HNF1A. Analysis of human data revealed an association of rs10517086_A genotype with C-peptide in 153 individuals with T1DM, but not in 417 people with T2DM. Our data suggest that rs1534422 and rs10517086 exert multiple insults on the β cell through excessive upregulation of HNF1A and the induction of pro-inflammatory cytokines. View this paper
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Articles (128)

  • Article
  • Open Access
1,563 Views
21 Pages

19 February 2025

Background/Objectives: Sterol regulatory element-binding transcription factor 2 (SREBF2) is a key transcription factor involved in regulating cholesterol homeostasis. However, its role in buffalo mammary gland lipid metabolism remains unclear. Method...

  • Article
  • Open Access
1,101 Views
10 Pages

The Relationship Between Genetic Variants at Loci 9p21, 6q25.1, and 2q36.3 and the Development of Cardiac Allograft Vasculopathy in Heart Transplant Patients

  • Dana Dlouha,
  • Kristyna Janouskova,
  • Jevgenija Vymetalova,
  • Sarka Novakova,
  • Sarka Chytilova,
  • Marianna Lukasova and
  • Jaroslav A. Hubacek

19 February 2025

Background: Cardiac allograft vasculopathy (CAV) is an accelerated form of coronary artery disease (CAD) that is characterized by concentric fibrous intimal hyperplasia along the length of coronary vessels, and is recognized as long-term complication...

  • Article
  • Open Access
3 Citations
1,259 Views
21 Pages

Exploring the Genotoxic Stress Response in Primed Orphan Legume Seeds Challenged with Heat Stress

  • Andrea Pagano,
  • Conrado Dueñas,
  • Nicolò Bedotto,
  • Amine Elleuch,
  • Bassem Khemakhem,
  • Hanen El Abed,
  • Eleni Tani,
  • Maria Goufa,
  • Dimosthenis Chachalis and
  • Alma Balestrazzi

19 February 2025

Background/Objectives: The increased frequency of extreme weather events related to climate change, including the occurrence of extreme temperatures, severely affects crop yields, impairing global food security. Heat stress resulting from temperature...

  • Article
  • Open Access
1,429 Views
17 Pages

Genome-Wide Analyses of the Soybean GmABCB Gene Family in Response to Salt Stress

  • Hui Zou,
  • Caiyun Fan,
  • Xiulin Chen,
  • Ruifeng Chen,
  • Zhihui Sun and
  • Xiaorong Wan

19 February 2025

Background: Soybean (Glycine max (L.) Merr.) is a significant economic oilseed crop, and saline-alkali soils restrict soybean yield. Identifying salt-tolerant genes is a key strategy for enhancing soybean productivity under saline-alkali conditions....

  • Article
  • Open Access
924 Views
15 Pages

Developmental Expression Patterns of miRNA in Mythimna separata Walker (Lepidotera: Noctuidae)

  • Yuhan Liu,
  • Huiman Tian,
  • Shaoqiu Ren,
  • Xiulin Chen,
  • Kun Luo,
  • Guangwei Li and
  • Boliao Li

19 February 2025

Background/Objectives: miRNAs are a family of single-stranded non-coding RNAs that regulate gene expression by targeting messenger RNAs (mRNAs) for suppression, with an average length of 22 nt. The oriental armyworm, Mythimna separata Walker, is a pe...

  • Article
  • Open Access
3,088 Views
9 Pages

The Survival of the Kiss: Presence and Persistence of Salivary Male DNA in Mixed Samples

  • Mauro Pesaresi,
  • Federica Alessandrini,
  • Elena Bignozzi,
  • Alessia Bernini Di Michele,
  • Filomena Melchionda,
  • Rosaria Gesuita,
  • Valerio Onofri and
  • Chiara Turchi

19 February 2025

Background/Objectives: The study of DNA transfer and persistence has become increasingly significant, driven by advancements in DNA detection sensitivity and the need for reliable forensic evidence. In forensic investigations, saliva and saliva-stain...

  • Review
  • Open Access
6 Citations
4,822 Views
31 Pages

19 February 2025

Nucleotide excision repair (NER) is a universal cut-and-paste DNA repair mechanism that corrects bulky DNA lesions such as those caused by UV radiation, environmental mutagens, and some chemotherapy drugs. In this review, we focus on the human transc...

  • Article
  • Open Access
1 Citations
1,465 Views
12 Pages

Human Papilloma Virus Infection in Men: A Specific Human Virome or a Specific Pathology?

  • Ivana Čulav,
  • Mihael Skerlev,
  • Lidija Žele Starčević,
  • Pero Hrabač,
  • Suzana Ljubojević Hadžavdić,
  • Iva Bešlić and
  • Liborija Lugović Mihić

18 February 2025

Background: Human papillomavirus (HPV) infections in men remain under-researched despite their critical role in disease transmission and the increasing incidence of HPV-related cancers. This study investigates the clinical and molecular characteristi...

  • Article
  • Open Access
1,510 Views
29 Pages

Unveiling Racial Disparities in Localized Prostate Cancer: A Systems-Level Exploration of the lncRNA Landscape

  • Rebecca A. Morgan,
  • E. Starr Hazard,
  • Stephen J. Savage,
  • Chanita Hughes Halbert,
  • Sebastiano Gattoni-Celli and
  • Gary Hardiman

17 February 2025

Background/Objectives: Prostate cancer (PC) is the most common non-cutaneous cancer in men globally, and one which displays significant racial disparities. Men of African descent (AF) are more likely to develop PC and face higher mortality compared t...

  • Brief Report
  • Open Access
1,126 Views
18 Pages

Identification of Ziziphus jujuba cv. Dongzao DNA Demethylase ZjROS1 Gene Family and Construction of CRISPR/Cas9-Mediated Gene-Editing Vector

  • Jiaqi Wang,
  • Huiran Wang,
  • Jiayi Zhai,
  • Fulun Zhu,
  • Yufeng Ren,
  • Jun Zhou,
  • Zhikai Zhang,
  • Lan Luo and
  • Wendi Xu

17 February 2025

DNA methylation is one of the earliest and most extensively studied epigenetic regulatory mechanisms. The ROS1 (Repressor of Silencing 1) gene was first discovered in Arabidopsis thaliana, and it is a DNA demethylase that can remove 5-methylcytosine...

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Genes - ISSN 2073-4425