The Role of RNA Regulation in Development and Disease
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "RNA".
Deadline for manuscript submissions: closed (25 December 2024) | Viewed by 2692
Special Issue Editor
Interests: nonsense-mediated mRNA decay; stem cell biology; neurodevelopmental disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Temporal and spatial regulation of gene expression are essential for animals’ development and tissue homeostasis, the loss of which is associated with developmental disorders and diseases. In recent years, researchers have developed a great body of evidence on epigenetic, transcriptional and post-translational mechanisms for the safeguarding of proper gene expression. RNAs, including rRNAs, mRNAs, and tRNAs, work to decode genetic information and transfer it to proteins with diverse cellular functions. During this process, RNA-binding proteins (RBPs), by recognizing specific sequence motifs in different RNAs, may impact the translation and stability of RNAs. Meanwhile, other RNA species (lncRNAs, circRNAs, etc.) may modulate the behavior of proteins through physical interactions with protein partners. Furthermore, RNA modifications and their writers, readers, and erasers have been found to determine the fate of RNAs and thus impact the fate of the cell as a whole; such findings represent a new frontier of research into RNA epitranscriptomics. Abnormalities in the regulation of aforementioned RNA dynamics and behaviors cause defects in cellular functions, contributing to various genetic disorders and degenerative diseases. The functions and mechanisms of RNA regulations during development and disease are less understood.
For this Special Issue entitled “The Role of RNA Regulation in Development and Disease”, we welcome the submission of new findings and cutting-edge reviews on RNA regulations and their biological functions. This SI will cover all areas of RNA- and RBP-related biology and biomedical studies conducted with cell lines, model species, and ethically approved human resources.
Prof. Dr. Tangliang Li
Guest Editor
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Keywords
- RNA epitranscriptomics
- RNA-binding protein (RBP)
- stem cells
- self-renewal and differentiation
- genetic disorders
- degenerative diseases
- cancer
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