Table of Contents
Genes, Volume 11, Issue 3 (March 2020) – 109 articles
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Cover Story (view full-size image) DNA helicases are motor enzymes that move directionally along the phosphodiester backbone to [...] Read more. DNA helicases are motor enzymes that move directionally along the phosphodiester backbone to catalyze ATP-dependent unwinding of duplex DNA. The discovery of viral, prokaryotic, and eukaryotic DNA helicases since the 1970s indicates their ubiquitous presence. DNA helicases have fundamentally important roles in virtually all aspects of nucleic acid metabolism including DNA replication and repair, recombination, transcription, and maintenance of genomic stability. Research by many laboratories has elucidated their molecular and cellular functions. Genetic defects in DNA helicases underlie hereditary diseases and cancers. Continued work in this area is anticipated to yield important new insights to the seminal importance of DNA helicases in genome biology. View this paper.