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Volume 11
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10.3390/genes11030338
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Article

Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population

by
Omar Graciano-Machuca
1,2,
Anabell Alvarado-Navarro
3,
María Guadalupe Ramírez-Dueñas
4,
Delfina Guadalupe Villanueva-Quintero
5,6,
Erandi Enif Velarde-de la Cruz
1,
Andrea Carolina Machado-Sulbarán
1,
Margarita Montoya-Buelna
4 and
Pedro Ernesto Sánchez-Hernández
4,*
1
Doctorate in Biomedical Sciences, Department of Physiology, University Center of Health Sciences (CUCS), University of Guadalajara (UDG), Guadalajara, Jal. 44340, Mexico
2
Laboratory of Biological Systems, Department of Health Sciences, University Center of the Valleys (CUVALLES), UDG, Ameca, Jal. 4660, Mexico
3
Research Center in Immunology and Dermatology, Department of Physiology, CUCS, UDG, Guadalajara, Jal. 44340, Mexico
4
Laboratory of Immunology, Department of Physiology, CUCS, UDG, Guadalajara, Jal. 44340, Mexico
5
Jalisco Dermatology Institute “Dr. José Barba Rubio”, Ministry of Health; Zapopan, Jal. 45190, Mexico
6
Inflammatory Diseases Care Center, Guadalajara, Jal. 44630, Mexico
*
Author to whom correspondence should be addressed.
Genes 2020, 11(3), 338; https://doi.org/10.3390/genes11030338
Submission received: 7 February 2020 / Revised: 10 March 2020 / Accepted: 20 March 2020 / Published: 22 March 2020
(This article belongs to the Special Issue Genetic Basis of Psoriasis)
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Abstract

NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating KIR genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association between KIR/HLA genes and genotypes with PsV in the Western mestizo Mexican population. One hundred subjects diagnosed with PsV (SP) and 108 healthy subjects (HS) were genotyped for 14 KIR genes, HLA-Bw4, HLA-C1, and HLA-C2 by PCR-single specific primer (SSP). Positive associations of the KIR3DS1 gene (odds ratio (OR) 1.959, p = 0.021), G11 genotype (OR 19.940, p = 0.008), and KIR3DS1/HLA-ABw4 (OR 2.265, p = 0.009) were found with susceptibility to PsV. In contrast, the G1 genotype (OR 0.448, p = 0.031) and KIR3DL1/HLA-Bw4Ile80 (OR 0.522, p = 0.022) were negatively associated with susceptibility to this disease. These results suggest an implication of the KIR3DS1/HLA-ABw4 genotype in PsV pathology.
Keywords: psoriasis vulgaris; KIR; HLA; KIR3DS1; HLA-Bw4 psoriasis vulgaris; KIR; HLA; KIR3DS1; HLA-Bw4

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MDPI and ACS Style

Graciano-Machuca, O.; Alvarado-Navarro, A.; Ramírez-Dueñas, M.G.; Villanueva-Quintero, D.G.; Velarde-de la Cruz, E.E.; Machado-Sulbarán, A.C.; Montoya-Buelna, M.; Sánchez-Hernández, P.E. Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population. Genes 2020, 11, 338. https://doi.org/10.3390/genes11030338

AMA Style

Graciano-Machuca O, Alvarado-Navarro A, Ramírez-Dueñas MG, Villanueva-Quintero DG, Velarde-de la Cruz EE, Machado-Sulbarán AC, Montoya-Buelna M, Sánchez-Hernández PE. Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population. Genes. 2020; 11(3):338. https://doi.org/10.3390/genes11030338

Chicago/Turabian Style

Graciano-Machuca, Omar, Anabell Alvarado-Navarro, María Guadalupe Ramírez-Dueñas, Delfina Guadalupe Villanueva-Quintero, Erandi Enif Velarde-de la Cruz, Andrea Carolina Machado-Sulbarán, Margarita Montoya-Buelna, and Pedro Ernesto Sánchez-Hernández. 2020. "Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population" Genes 11, no. 3: 338. https://doi.org/10.3390/genes11030338

APA Style

Graciano-Machuca, O., Alvarado-Navarro, A., Ramírez-Dueñas, M. G., Villanueva-Quintero, D. G., Velarde-de la Cruz, E. E., Machado-Sulbarán, A. C., Montoya-Buelna, M., & Sánchez-Hernández, P. E. (2020). Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population. Genes, 11(3), 338. https://doi.org/10.3390/genes11030338

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