Cells, Volume 9, Issue 1 (January 2020) – 259 articles
Cover Story (view full-size image): As we age, failure to maintain the structural interface between muscle fibers and the motoneuron known as the neuromuscular junction (NMJ) leads to muscle fiber denervation, which in turn precipitates many of the most severe consequences of aging in skeletal muscle, including the decline in muscle mass and strength. Mitochondria are strongly implicated in aging biology and are particularly enriched on both sides of the NMJ. Here, we focus on the role of the mitochondrion in the age-related deterioration of the NMJ, taking account of the impact of aging on mitochondrial structure and function in muscle fibers and motoneurons. We also review the role of mtDNA alterations, mitochondrial dynamics, and the related maintenance of the mitochondrial number and quality known as mitostasis, in the mitochondrial changes occurring at the aging NMJ. View this paper.
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