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Toxins, Volume 17, Issue 4

2025 April - 59 articles

Cover Story: In this study, the role of the histone methyltransferases AcDot1 and AcRmtA in Aspergillus carbonarius was investigated. Knockout or overexpression mutants were obtained through Agrobacterium tumefaciens-mediated transformation. The deletion of Acdot1 or AcrmtA resulted in the up-regulation of growth on a minimal medium. The influence of Acdot1 on OTA biosynthesis was affected by culture conditions, while the deletion of AcrmtA consistently resulted in lower OTA accumulation. The expression of otaC, otaB and otaD was reduced in ΔAcrmtA. Both methyltransferases played a role in the oxidative stress response. Neither the deletion nor the overexpression of Acdot1 or AcrmtA affected virulence, while both sporulation and OTA production were affected in vivo by the deletion of AcrmtAView this paper
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Articles (59)

  • Article
  • Open Access
1 Citations
2,104 Views
18 Pages

13 April 2025

Scorpion antipredator behavior incorporates risk assessment that informs decision-making and venom usage. We quantified antipredator behaviors of the clinically significant Arizona bark scorpion (Centruroides sculpturatus) in their natural environmen...

  • Article
  • Open Access
3,027 Views
16 Pages

A 20-Year Retrospective Analysis of Plant Poisoning Cases at the Naval Hospital, Varna, Bulgaria

  • Stanila Stoeva-Grigorova,
  • Maya Radeva-Ilieva,
  • Stela Dragomanova,
  • Gabriela Kehayova,
  • Simeonka Dimitrova,
  • Simeon Marinov,
  • Petko Marinov,
  • Marieta Yovcheva,
  • Diana Ivanova and
  • Snezha Zlateva

12 April 2025

The nature and epidemiology of plant intoxications are still not well understood, with recent data being limited. The present study aims to report cases of plant poisoning in the clinical practice of the Clinical Toxicology Department at the Naval Ho...

  • Article
  • Open Access
1,133 Views
22 Pages

Histone Methyltransferases AcDot1 and AcRmtA Are Involved in Growth Regulation, Secondary Metabolism, and Stress Response in Aspergillus carbonarius

  • Angelo Agnusdei,
  • Adrián González-García,
  • Donato Gerin,
  • Stefania Pollastro,
  • Francesco Faretra,
  • Luis González-Candelas and
  • Ana-Rosa Ballester

12 April 2025

Histone post-translational modifications (HPTMs) can affect gene expression by rearranging chromatin structure. Between these, histone methylation is one of the most studied in filamentous fungi, and different conserved domains coding for methyltrans...

  • Article
  • Open Access
1,043 Views
24 Pages

Transcriptomics as an Early Warning of Domoic Acid Exposure in Pacific Razor Clams (Siliqua patula)

  • Lizabeth Bowen,
  • Shannon Waters,
  • Brenda Ballachey,
  • Heather Coletti,
  • Zachary Forster,
  • Jie Li and
  • Bradley Jenner

11 April 2025

As oceans warm, harmful algal blooms (HABs) are expected to increase, including blooms of Pseudo-nitzschia, a diatom that produces domoic acid (DA), which is a potent neurotoxin. Regulatory limits for human consumption (0.075–0.1 mg/kg/day; acu...

  • Review
  • Open Access
5 Citations
1,774 Views
23 Pages

11 April 2025

The hypothesis that disturbance to coral reefs creates new surfaces that increase the risk of ciguatera is premised upon the increased algal substrates that develop on these surfaces being colonised by high ciguatoxin (CTX)-producing Gambierdiscus sp...

  • Article
  • Open Access
2 Citations
2,622 Views
17 Pages

Electrical Cell Impedance Sensing (ECIS): Feasibility of a Novel In Vitro Approach to Studying Venom Toxicity and Potential Therapeutics

  • Abhinandan Choudhury,
  • Kaitlin Linne,
  • Tommaso C. Bulfone,
  • Tanvir Hossain,
  • Abu Ali Ibn Sina,
  • Philip L. Bickler,
  • Bryan G. Fry and
  • Matthew R. Lewin

11 April 2025

Snakebite envenoming is often discussed in terms of lethality and limb loss, but local tissue injury and coagulotoxic effects of venom are significantly more common acute manifestations of snakebite envenoming (SBE). Local tissue injury and the hemor...

  • Review
  • Open Access
3 Citations
7,049 Views
9 Pages

Safety of Onabotulinumtoxin-A for Chronic Migraine During Pregnancy and Breastfeeding: A Narrative Review

  • Antonio Russo,
  • Luigi Francesco Iannone,
  • Ilaria Orologio,
  • Veronica Rivi,
  • Alberto Boccalini,
  • Flavia Lo Castro,
  • Marcello Silvestro and
  • Simona Guerzoni

11 April 2025

Onabotulinumtoxin-A (onabotA) is a neurotoxin widely used for several indications, including chronic migraine (CM) preventive treatment, due to its well-demonstrated efficacy, tolerability, and safety. However, onabotA safety during pregnancy and bre...

  • Reply
  • Open Access
793 Views
3 Pages

11 April 2025

We thank Trosch et al [...]

  • Comment
  • Open Access
1 Citations
952 Views
3 Pages

11 April 2025

We read with interest and some concern the article by Dashtipour and colleagues [...]

  • Case Report
  • Open Access
1 Citations
2,929 Views
11 Pages

Poisoning from Alocasia × amazonica Roots: A Case Report

  • Stanila Stoeva-Grigorova,
  • Stela Dragomanova,
  • Maya Radeva-Ilieva,
  • Gabriela Kehayova,
  • Simeonka Dimitrova,
  • Simeon Marinov,
  • Petko Marinov,
  • Marieta Yovcheva,
  • Diana Ivanova and
  • Snezha Zlateva

10 April 2025

All parts of Alocasia × amazonica (A. amazonica, Araceae) pose a toxicological risk due to oxalate production. Ingestion of the plant extract may cause multi-organ damage and fatal outcomes. Given the rarity of poisoning cases, its toxicologica...

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Toxins - ISSN 2072-6651