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Article

Caloric Restriction Prevents Metabolic Dysfunction and the Changes in Hypothalamic Neuropeptides Associated with Obesity Independently of Dietary Fat Content in Rats

1
Department of Pathology, Anatomy and Physiology, University of Navarra, IdiSNA, 31008 Pamplona, Spain
2
Metabolic Research Laboratory, Clínica Universidad de Navarra, IdiSNA, 31008 Pamplona, Spain
3
CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
4
Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain
5
Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, 31008 Pamplona, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Emiliana Giacomello, Luana Toniolo and Marcellino Monda
Nutrients 2021, 13(7), 2128; https://doi.org/10.3390/nu13072128
Received: 14 May 2021 / Revised: 3 June 2021 / Accepted: 15 June 2021 / Published: 22 June 2021
(This article belongs to the Special Issue Nutrition, Diet and Healthy Aging)
Energy restriction is a first therapy in the treatment of obesity, but the underlying biological mechanisms have not been completely clarified. We analyzed the effects of restriction of high-fat diet (HFD) on weight loss, circulating gut hormone levels and expression of hypothalamic neuropeptides. Ten-week-old male Wistar rats (n = 40) were randomly distributed into four groups: two fed ad libitum a normal diet (ND) (N group) or a HFD (H group) and two subjected to a 25% caloric restriction of ND (NR group) or HFD (HR group) for 9 weeks. A 25% restriction of HFD over 9 weeks leads to a 36% weight loss with regard to the group fed HFD ad libitum accompanied by normal values in adiposity index and food efficiency ratio (FER). This restriction also carried the normalization of NPY, AgRP and POMC hypothalamic mRNA expression, without changes in CART. Caloric restriction did not succeed in improving glucose homeostasis but reduced HFD-induced hyperinsulinemia. In conclusion, 25% restriction of HFD reduced adiposity and improved metabolism in experimental obesity, without changes in glycemia. Restriction of the HFD triggered the normalization of hypothalamic NPY, AgRP and POMC expression, as well as ghrelin and leptin levels. View Full-Text
Keywords: food restriction; gut hormones; hypothalamic neuropeptides and obesity food restriction; gut hormones; hypothalamic neuropeptides and obesity
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MDPI and ACS Style

Martín, M.; Rodríguez, A.; Gómez-Ambrosi, J.; Ramírez, B.; Becerril, S.; Catalán, V.; López, M.; Diéguez, C.; Frühbeck, G.; Burrell, M.A. Caloric Restriction Prevents Metabolic Dysfunction and the Changes in Hypothalamic Neuropeptides Associated with Obesity Independently of Dietary Fat Content in Rats. Nutrients 2021, 13, 2128. https://doi.org/10.3390/nu13072128

AMA Style

Martín M, Rodríguez A, Gómez-Ambrosi J, Ramírez B, Becerril S, Catalán V, López M, Diéguez C, Frühbeck G, Burrell MA. Caloric Restriction Prevents Metabolic Dysfunction and the Changes in Hypothalamic Neuropeptides Associated with Obesity Independently of Dietary Fat Content in Rats. Nutrients. 2021; 13(7):2128. https://doi.org/10.3390/nu13072128

Chicago/Turabian Style

Martín, Marina, Amaia Rodríguez, Javier Gómez-Ambrosi, Beatriz Ramírez, Sara Becerril, Victoria Catalán, Miguel López, Carlos Diéguez, Gema Frühbeck, and María A. Burrell. 2021. "Caloric Restriction Prevents Metabolic Dysfunction and the Changes in Hypothalamic Neuropeptides Associated with Obesity Independently of Dietary Fat Content in Rats" Nutrients 13, no. 7: 2128. https://doi.org/10.3390/nu13072128

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