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Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Carsten Carlberg
Nutrients 2021, 13(7), 2129;
Received: 20 May 2021 / Revised: 11 June 2021 / Accepted: 18 June 2021 / Published: 22 June 2021
(This article belongs to the Section Micronutrients and Human Health)
(1) Background: Vitamin D, a well-established regulator of calcium and phosphate metabolism, also has immune-modulatory functions. An uncontrolled immune response and cytokine storm are tightly linked to fatal courses of COVID-19. The present retrospective study aimed to inves-tigate vitamin D status markers and vitamin D degradation products in a mixed cohort of 148 hospitalized COVID-19 patients with various clinical courses of COVID-19. (2) Methods: The serum concentrations of 25(OH)D3, 25(OH)D2, 24,25(OH)2D3, and 25,26(OH)2D3 were determined by a validated liquid-chromatography tandem mass-spectrometry method in leftover serum samples from 148 COVID-19 patients that were admitted to the University Hospital of the Medical Uni-versity of Graz between April and November 2020. Anthropometric and clinical data, as well as outcomes were obtained from the laboratory and hospital information systems. (3) Results: From the 148 patients, 34 (23%) died within 30 days after admission. The frequency of fatal outcomes did not differ between males and females. Non-survivors were significantly older than survivors, had higher peak concentrations of IL-6 and CRP, and required mechanical ventilation more frequently. The serum concentrations of all vitamin D metabolites and the vitamin D metabolite ratio (VMR) did not differ significantly between survivors and non-survivors. Additionally, the need for res-piratory support was unrelated to the serum concentrations of 25(OH)D vitamin D and the two vitamin D catabolites, as well as the VMR. (4) Conclusion: The present results do not support a relevant role of vitamin D for the course and outcome of COVID-19. View Full-Text
Keywords: vitamin D metabolites; COVID19; clinical outcome vitamin D metabolites; COVID19; clinical outcome
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MDPI and ACS Style

Zelzer, S.; Prüller, F.; Curcic, P.; Sloup, Z.; Holter, M.; Herrmann, M.; Mangge, H. Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients. Nutrients 2021, 13, 2129.

AMA Style

Zelzer S, Prüller F, Curcic P, Sloup Z, Holter M, Herrmann M, Mangge H. Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients. Nutrients. 2021; 13(7):2129.

Chicago/Turabian Style

Zelzer, Sieglinde, Florian Prüller, Pero Curcic, Zdenka Sloup, Magdalena Holter, Markus Herrmann, and Harald Mangge. 2021. "Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients" Nutrients 13, no. 7: 2129.

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