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Article

Protective Effects of Small-Molecule Oligopeptides Isolated from Tilapia Fish Scale on Ethanol-Induced Gastroduodenal Injury in Rats

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China
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Author to whom correspondence should be addressed.
Academic Editors: Yula Sambuy and Carmen Lammi
Nutrients 2021, 13(6), 2078; https://doi.org/10.3390/nu13062078
Received: 15 May 2021 / Revised: 12 June 2021 / Accepted: 14 June 2021 / Published: 17 June 2021
(This article belongs to the Special Issue Bioactive Peptides)
Peptic ulcer has a serious impact on people’s health around the world, and traditional medicines can cause adverse reactions. This study investigated the protective effects of tilapia collagen oligopeptides (TCOPs) on gastroduodenal injury. Seventy-two specific pathogen-free (SPF) male Sprague Dawley (SD) rats were randomly divided into six groups according to body weight: normal control group, ethanol group, whey protein group (500 mg/kg BW), and three TCOPs dose groups (250, 500, 1000 mg/kg BW). After intragastric administration for 30 days, the acute gastroduodenal injury was induced by anhydrous ethanol (5 mL/kg, intragastrically) in all groups except the normal control group. Biomarkers in gastric and duodenal tissue and serum were measured. Furthermore, western blot was used to detect the expression of apoptosis-related proteins. The results showed that the administration with TCOPs significantly reduced gastric and duodenal ulcer index, increased gastric juice pH, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, along with the reduction of malondialdehyde (MDA) contents. TCOPs decreased tumor Necrosis Factor-α (TNF-α), interleukin-1β (IL-1β), and myeloperoxidase (MPO) levels, while interleukin– 10 (IL-10) levels were increased. Furthermore, pepsinogens 1 (PG1), pepsinogens 2 (PG2), gastrin (GAS), and the pepsinogen ratio (PGR) were decreased, the prostaglandin E2 (PGE2) and NO contents were increased after TCOPs intervention. Moreover, TCOPs up-regulated the expression of Bcl-2 and inhibited the expression of Bax and Caspase-3. In conclusion, TCOPs have protective effects on ethanol-induced gastroduodenal injury through gastrointestinal mucosal microcirculation promotion, antioxidation, anti-inflammation, and anti-apoptosis mechanisms. View Full-Text
Keywords: tilapia collagen oligopeptides; gastroduodenal injury; antioxidant; anti-inflammation; anti-apoptosis tilapia collagen oligopeptides; gastroduodenal injury; antioxidant; anti-inflammation; anti-apoptosis
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MDPI and ACS Style

Hu, J.; Liu, R.; Yu, X.; Li, Z.; Liu, X.; Hao, Y.; Zhu, N.; Kang, J.; Li, Y. Protective Effects of Small-Molecule Oligopeptides Isolated from Tilapia Fish Scale on Ethanol-Induced Gastroduodenal Injury in Rats. Nutrients 2021, 13, 2078. https://doi.org/10.3390/nu13062078

AMA Style

Hu J, Liu R, Yu X, Li Z, Liu X, Hao Y, Zhu N, Kang J, Li Y. Protective Effects of Small-Molecule Oligopeptides Isolated from Tilapia Fish Scale on Ethanol-Induced Gastroduodenal Injury in Rats. Nutrients. 2021; 13(6):2078. https://doi.org/10.3390/nu13062078

Chicago/Turabian Style

Hu, Jiani, Rui Liu, Xiaochen Yu, Zhen Li, Xinran Liu, Yuntao Hao, Na Zhu, Jiawei Kang, and Yong Li. 2021. "Protective Effects of Small-Molecule Oligopeptides Isolated from Tilapia Fish Scale on Ethanol-Induced Gastroduodenal Injury in Rats" Nutrients 13, no. 6: 2078. https://doi.org/10.3390/nu13062078

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