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Article

Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT

1
Department of Nutrition and Dietetics, Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, 1067 SM Amsterdam, The Netherlands
2
Netherlands Organisation for Applied Scientific Research (TNO), 3704 HE Zeist, The Netherlands
3
Danone Nutricia Research, Specialized Nutrition, 3584 CT Utrecht, The Netherlands
4
Vialente-Diëtheek, 3447 GW Woerden, The Netherlands
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Tromp Medical, 1901 ND Castricum, The Netherlands
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Department of Rehabilitation Medicine, Amsterdam University Medical Centers, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
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Department of Nutrition and Dietetics, Amsterdam University Medical Centers, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(1), 64; https://doi.org/10.3390/nu13010064
Received: 3 November 2020 / Revised: 21 December 2020 / Accepted: 23 December 2020 / Published: 28 December 2020
(This article belongs to the Special Issue Nutrition for Older Persons' Health)
Background: Weight loss is key to treatment of older adults with obesity and type 2 diabetes, but also a risk for muscle mass loss. This study investigated whether a whey protein drink enriched with leucine and vitamin D could preserve muscle mass and improve glycemic control during combined lifestyle intervention in this population. Methods: 123 older adults with obesity and type 2 diabetes were randomized into a 13-week lifestyle intervention with dietary advice and exercise, receiving either the enriched protein drink (test) or an isocaloric control (control). Muscle mass was assessed with dual-energy X-ray absorptiometry and glycemic control by oral glucose tolerance test. Statistical analyses were performed using a linear mixed model. Results: There was a nonsignificant increase in leg muscle mass (+0.28 kg; 95% CI, −0.01 to 0.56) and a significant increase in appendicular muscle mass (+0.36 kg; 95% CI, 0.005 to 0.71) and total lean mass (+0.92 kg; 95% CI, 0.19 to 1.65) in test vs. control. Insulin sensitivity (Matsuda index) also increased in test vs. control (+0.52; 95% CI, 0.07 to 0.97). Conclusions: Use of an enriched protein drink during combined lifestyle intervention shows beneficial effects on muscle mass and glycemic control in older adults with obesity and type 2 diabetes. View Full-Text
Keywords: overweight; weight loss; diabetes; elderly; protein; lean mass; insulin sensitivity overweight; weight loss; diabetes; elderly; protein; lean mass; insulin sensitivity
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MDPI and ACS Style

Memelink, R.G.; Pasman, W.J.; Bongers, A.; Tump, A.; van Ginkel, A.; Tromp, W.; Wopereis, S.; Verlaan, S.; de Vogel-van den Bosch, J.; Weijs, P.J.M. Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT. Nutrients 2021, 13, 64. https://doi.org/10.3390/nu13010064

AMA Style

Memelink RG, Pasman WJ, Bongers A, Tump A, van Ginkel A, Tromp W, Wopereis S, Verlaan S, de Vogel-van den Bosch J, Weijs PJM. Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT. Nutrients. 2021; 13(1):64. https://doi.org/10.3390/nu13010064

Chicago/Turabian Style

Memelink, Robert G., Wilrike J. Pasman, Anke Bongers, Anita Tump, Annemieke van Ginkel, Wim Tromp, Suzan Wopereis, Sjors Verlaan, Johan de Vogel-van den Bosch, and Peter J. M. Weijs. 2021. "Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT" Nutrients 13, no. 1: 64. https://doi.org/10.3390/nu13010064

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