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Decreased Consumption of Added Fructose Reduces Waist Circumference and Blood Glucose Concentration in Patients with Overweight and Obesity. The DISFRUTE Study: A Randomised Trial in Primary Care

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Centro de Salud La Victoria de Acentejo-Tenerife, Calle Domingo Salazar 21, 38380 Tenerife, Canary Islands, Spain
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Unidad de Investigación de la Gerencia de Atención Primaria de Tenerife y del Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, 38310 Tenerife, Canary Islands, Spain
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Centro de Salud La Victoria de Acentejo, 38380 Tenerife, Canary Islands, Spain
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Centro de Salud de Güimar 38500Tenerife, Canary Islands, Spain
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Centro de Salud de la Orotava San Antonio, 38313 Tenerife, Canary Islands, Spain
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Centro de Salud Ruiz de Padrón, 38002 Tenerife, Canary Islands, Spain
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Laboratorio del Complejo Hospitalario Universitario de Canarias, 38320 La Laguna, Canary Islands, Spain
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Health Care Research Institute of the Santa Cruz de Tenerife College of Nursing, Colegio Oficial de Enfermeros de Santa Cruz de Tenerife, 38001 Tenerife, Spain
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European University of the Canary Islands–Member of Laureate International Universities, 38001 Tenerife, Canary Islands, Spain
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Unidad de Investigación de la Gerencia de Atención Primaria de Tenerife y del Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, 38010 Tenerife, Canary Islands, Spain
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Departamento de Medicina Preventiva y Salud Pública de la Universidad de la Laguna, 38200 La Laguna, Canary Island, Spain
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Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1149; https://doi.org/10.3390/nu12041149
Received: 7 March 2020 / Revised: 8 April 2020 / Accepted: 15 April 2020 / Published: 19 April 2020
(This article belongs to the Special Issue Dietary Modifications and Human Health)
The relationship between fructose intake and insulin resistance remains controversial. Our purpose was to determine whether a reduction in dietary fructose is effective in decreasing insulin resistance (HOMA2-IR). This field trial was conducted on 438 adults with overweight and obese status, without diabetes. A total of 121 patients in a low fructose diet (LFD) group and 118 in a standard diet (SD) group completed the 24-week study. Both diets were prescribed with 30–40% of energy intake restriction. There were no between-group differences in HOMA2-IR. However, larger decreases were seen in the LFD group in waist circumference (−7.0 vs. −4.8 = −2.2 cms, 95% CI: −3.7, −0.7) and fasting blood glucose −0.25 vs. −0.11 = −0.14 mmol/L, 95% CI: −0.028, −0.02). The percentage of reduction in calorie intake was similar. Only were differences observed in the % energy intake for some nutrients: total fructose (−2 vs. −0.6 = −1.4, 95% CI: −2.6, −0.3), MUFA (−1.7 vs. −0.4 = −1.3, 95% CI: −2.4, −0.2), protein (5.1 vs. 3.6 = 1.4, 95% CI: 0.1, 2.7). The decrease in fructose consumption originated mainly from the reduction in added fructose (−2.8 vs. −1.9 = −0.9, 95% CI: −1.6, −0.03). These results were corroborated after multivariate adjustments. The low fructose diet did not reduce insulin resistance. However, it reduced waist circumference and fasting blood glucose concentration, which suggests a decrease in hepatic insulin resistance. View Full-Text
Keywords: fructose; insulin resistance; sugars; clinical trial; obesity; non-alcoholic fatty liver disease (NAFLD); primary health care fructose; insulin resistance; sugars; clinical trial; obesity; non-alcoholic fatty liver disease (NAFLD); primary health care
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Domínguez-Coello, S.; Carrillo-Fernández, L.; Gobierno-Hernández, J.; Méndez-Abad, M.; Borges-Álamo, C.; García-Dopico, J.A.; Aguirre-Jaime, A.; Cabrera-de León, A. Decreased Consumption of Added Fructose Reduces Waist Circumference and Blood Glucose Concentration in Patients with Overweight and Obesity. The DISFRUTE Study: A Randomised Trial in Primary Care. Nutrients 2020, 12, 1149.

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