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The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea
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Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1079; https://doi.org/10.3390/nu12041079
Received: 11 March 2020 / Revised: 2 April 2020 / Accepted: 9 April 2020 / Published: 13 April 2020
(This article belongs to the Section Phytochemicals and Human Health)
Sarcopenia is a muscle disease featured by the loss of muscle mass and dysfunction with advancing age. The 5,7-dimethoxyflavone (DMF), a major flavone found in Kaempferia parviflora, has biological activities, including anti-diabetes, anti-obesity, and anti-inflammation. However, its anti-sarcopenic effect remains to be elucidated. This current study investigated the inhibitory activity of DMF on sarcopenia. Eighteen-month-old mice were orally administered DMF at the dose of 25 mg·kg−1·day−1 or 50 mg·kg−1·day−1 for 8 weeks. DMF not only stimulated grip strength and exercise endurance but also increased muscle mass and volume. Besides, DMF stimulated the phosphatidylinositol 3-kinase-Akt pathway, consequently activating the mammalian target of rapamycin-eukaryotic initiation factor 4E-binding protein 1-70-kDa ribosomal protein S6 kinase pathway for protein synthesis. DMF reduced the mRNA expression of E3 ubiquitin ligase- and autophagy-lysosomal-related genes involved in proteolysis via the phosphorylation of Forkhead box O3. DMF upregulated peroxisome proliferator-activated receptor-gamma coactivator 1 alpha, nuclear respiratory factor 1, and mitochondrial transcription factor A along with the increase of relative mitochondrial DNA content. DMF alleviated inflammatory responses by reducing the tumor necrosis factor-alpha and interleukin-6 serum and mRNA levels. Collectively, DMF can be used as a natural agent to inhibit sarcopenia via improving protein turnover and mitochondria function. View Full-Text
Keywords: 5,7-dimethoxyflavone; skeletal muscle; sarcopenia; aging 5,7-dimethoxyflavone; skeletal muscle; sarcopenia; aging
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MDPI and ACS Style

Kim, C.; Hwang, J.-K. The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways. Nutrients 2020, 12, 1079. https://doi.org/10.3390/nu12041079

AMA Style

Kim C, Hwang J-K. The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways. Nutrients. 2020; 12(4):1079. https://doi.org/10.3390/nu12041079

Chicago/Turabian Style

Kim, Changhee, and Jae-Kwan Hwang. 2020. "The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways" Nutrients 12, no. 4: 1079. https://doi.org/10.3390/nu12041079

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