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Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats

by 1,†, 1,2,†, 2 and 1,2,*
1
Institute for Aging and Clinical Nutrition Research, Gachon University, Gyeonggi-do 13120, Korea
2
Department of Food and Nutrition, Gachon University, Gyeonggi-do 13120, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(3), 808; https://doi.org/10.3390/nu12030808
Received: 21 February 2020 / Revised: 16 March 2020 / Accepted: 17 March 2020 / Published: 19 March 2020
(This article belongs to the Section Phytochemicals and Human Health)
Gastric ulcers are a common gastrointestinal disease across the globe. Alcohol consumption is the primary cause of gastric carcinogenesis and progression. We investigated the gastroprotective effects of fermented lotus root (FL) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model and the conceivable underlying mechanisms involved. Rats received different doses of FL (50, 100, and 200 mg/kg) or ranitidine (positive control, 30 mg/kg) via oral gavage daily for 14 days. One hour after the last oral administration of FL, the EtOH/HCl mixture was orally intubated to induce gastric damage. Oral administration of FL significantly alleviated the gastric lesions. Moreover, FL also elevated the amounts of nitric oxide and the antioxidant enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase in the stomach. To verify the gastric mucosal defense mechanism, inflammation-related genes were measured. Our results revealed that FL effectively inhibited gastric mucosal damage via downregulation of the nuclear factor-kappaB (NF-κB) response in the stomach. The administration of FL significantly lowered the gastric mRNA expression of inflammation-related genes, including NF-κb1, tumor necrosis factor-α, interferon γ, and prostaglandin-endoperoxide synthase 2, compared with the gastric ulcer control group. In addition, the NF-κB signaling pathway-related protein markers inhibitor of κB (IκB)-α, IκB kinase, and NF-κB were significantly reduced in the FL groups. Taken together, these data suggest that FL administration may have potential as an alternative treatment for gastric ulcers due to its antioxidant and anti-inflammatory effects and its ability to promote the recovery of gastric mucosa. View Full-Text
Keywords: fermented lotus root; gastric ulcer; gastroprotective effect; anti-inflammatory effect; antioxidant effect fermented lotus root; gastric ulcer; gastroprotective effect; anti-inflammatory effect; antioxidant effect
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MDPI and ACS Style

Yoo, J.-H.; Park, E.-J.; Kim, S.H.; Lee, H.-J. Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats. Nutrients 2020, 12, 808. https://doi.org/10.3390/nu12030808

AMA Style

Yoo J-H, Park E-J, Kim SH, Lee H-J. Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats. Nutrients. 2020; 12(3):808. https://doi.org/10.3390/nu12030808

Chicago/Turabian Style

Yoo, Jeong-Hyun, Eun-Jung Park, So H. Kim, and Hae-Jeung Lee. 2020. "Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats" Nutrients 12, no. 3: 808. https://doi.org/10.3390/nu12030808

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