Next Article in Journal
Effectiveness of an Adult Food Literacy Program
Next Article in Special Issue
Mechanisms of Carotenoid Intestinal Absorption: Where Do We Stand?
Previous Article in Journal
Investigating Risk of Suboptimal Macro and Micronutrient Intake and Their Determinants in Older Danish Adults with Specific Focus on Protein Intake—A Cross-Sectional Study
Previous Article in Special Issue
Serum Lutein is related to Relational Memory Performance
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Nutrients 2019, 11(4), 796; https://doi.org/10.3390/nu11040796

A Lipophilic Fucoxanthin-Rich Phaeodactylum tricornutum Extract Ameliorates Effects of Diet-Induced Obesity in C57BL/6J Mice

1
Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Department of Physiology and Biochemistry of Nutrition, 76131 Karlsruhe, Germany
2
Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears, 07122 Palma de Mallorca, Spain
3
Institute of Interfacial Process Engineering and Plasma Technology IGVP, University of Stuttgart, 70569 Stuttgart, Germany
4
Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, 70569 Stuttgart, Germany
5
Karlsruhe Institute of Technology (KIT), Institute of Process Engineering in Life Sciences III Bioprocess Engineering, 76131 Karlsruhe, Germany
6
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 07122 Palma de Mallorca, Spain
7
Institut d’Investigació Sanitària Illes Balears (IdISBa), 07120 Palma de Mallorca, Spain
*
Author to whom correspondence should be addressed.
Received: 6 March 2019 / Revised: 3 April 2019 / Accepted: 4 April 2019 / Published: 6 April 2019
(This article belongs to the Special Issue Carotenoids and Human Health)
  |  
PDF [3088 KB, uploaded 19 April 2019]
  |  

Abstract

Phaeodactylum tricornutum (P. tricornutum) comprise several lipophilic constituents with proposed anti-obesity and anti-diabetic properties. We investigated the effect of an ethanolic P. tricornutum extract (PTE) on energy metabolism in obesity-prone mice fed a high fat diet (HFD). Six- to eight-week-old male C57BL/6J mice were switched to HFD and, at the same time, received orally placebo or PTE (100 mg or 300 mg/kg body weight/day). Body weight, body composition, and food intake were monitored. After 26 days, blood and tissue samples were collected for biochemical, morphological, and gene expression analyses. PTE-supplemented mice accumulated fucoxanthin metabolites in adipose tissues and attained lower body weight gain, body fat content, weight of white adipose tissue (WAT) depots, and inguinal WAT adipocyte size than controls, independent of decreased food intake. PTE supplementation was associated with lower expression of Mest (a marker of fat tissue expandability) in WAT depots, lower gene expression related to lipid uptake and turnover in visceral WAT, increased expression of genes key to fatty acid oxidation and thermogenesis (Cpt1, Ucp1) in subcutaneous WAT, and signs of thermogenic activation including enhanced UCP1 protein in interscapular brown adipose tissue. In conclusion, these data show the potential of PTE to ameliorate HFD-induced obesity in vivo. View Full-Text
Keywords: Phaeodactylum tricornutum; microalgae; fucoxanthin; eicosapentanoic acid; obesity; browning; brown adipose tissue Phaeodactylum tricornutum; microalgae; fucoxanthin; eicosapentanoic acid; obesity; browning; brown adipose tissue
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary materials

SciFeed

Share & Cite This Article

MDPI and ACS Style

Gille, A.; Stojnic, B.; Derwenskus, F.; Trautmann, A.; Schmid-Staiger, U.; Posten, C.; Briviba, K.; Palou, A.; Bonet, M.L.; Ribot, J. A Lipophilic Fucoxanthin-Rich Phaeodactylum tricornutum Extract Ameliorates Effects of Diet-Induced Obesity in C57BL/6J Mice. Nutrients 2019, 11, 796.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top