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Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function

1
Non-Clinical Evaluation Center, Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Chonbuk 54907, Korea
2
Department of Pharmacology and New Drug Development Institute, Chonbuk National University Medical School, Jeonju, Chonbuk 54896, Korea
3
Division of Food and Nutrition, College of Human Ecology, Chonnam National University, Gwang-ju 61186, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(2), 426; https://doi.org/10.3390/nu11020426
Received: 8 January 2019 / Revised: 13 February 2019 / Accepted: 14 February 2019 / Published: 18 February 2019
The recent discovery that the impairment of autophagic flux in non-alcoholic fatty liver disease (NAFLD) might be a strong determining factor in steatosis suggests the potential of therapeutic control of autophagic flux with natural agents in restoring NAFLD. We investigated the potential of Eucommia ulmoides leaf extract (EUL) to control dyslipidemia in NAFLD. EUL supplementation (200 mg/kg) promoted recovery from high fat diet (HFD)-induced lipid dysmetabolism. This hepatoprotective efficacy was accompanied by suppression of endoplasmic reticulum (ER) stress, enhancing lysosomal functions, and thereby increasing autophagic flux. We found a strong indication that inhibition of the mTOR-ER stress pathway was related to the enhanced autophagic flux. However, the direct antioxidative effect of EUL on cytoprotection cannot be ruled out as a significant contributing factor in NAFLD. Our findings will aid in further elucidating the mechanism of the anti-steatosis activity of EUL and highlight the therapeutic potential of EUL in the treatment of NAFLD. View Full-Text
Keywords: NAFLD; ER stress; Eucommia ulmoides leaf; autophagy; mTOR NAFLD; ER stress; Eucommia ulmoides leaf; autophagy; mTOR
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MDPI and ACS Style

Lee, G.-H.; Lee, H.-Y.; Park, S.-A.; Shin, T.-S.; Chae, H.-J. Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function. Nutrients 2019, 11, 426.

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