Next Article in Journal
Preconception Lifestyle and Cardiovascular Health in the Offspring of Overweight and Obese Women
Next Article in Special Issue
Anti-Atherosclerotic Properties of Wild Rice in Low-Density Lipoprotein Receptor Knockout Mice: The Gut Microbiome, Cytokines, and Metabolomics Study
Previous Article in Journal
In Vivo Effects of Polymerized Anthocyanin from Grape Skin on Benign Prostatic Hyperplasia
Previous Article in Special Issue
Comparative Investigation of Frankincense Nutraceuticals: Correlation of Boswellic and Lupeolic Acid Contents with Cytokine Release Inhibition and Toxicity against Triple-Negative Breast Cancer Cells
Open AccessArticle

Intervention Study on the Efficacy and Safety of Platycodon grandiflorus Ethanol Extract in Overweight or Moderately Obese Adults: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial

1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kyungpook National University, Daegu 41566, Korea
2
Center for Food and Nutritional Genomics Research, Kyungpook National University, 1370 San-Kyuk DongPuk-Ku, Daegu 41566, Korea
3
Department of Food Science and Nutrition, Kyungpook National University, 1370 San-Kyuk Dong Puk-Ku, Daegu 41566, Korea
4
Research Institute of Applied Animal Science, Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea
5
Business Deveopment Division, GC WellBeing Corporation, Gyeonggi-do, Seongnam 13595, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2445; https://doi.org/10.3390/nu11102445
Received: 9 September 2019 / Revised: 30 September 2019 / Accepted: 5 October 2019 / Published: 14 October 2019
(This article belongs to the Special Issue Nutraceutical, Nutrition Supplements and Human Health)
Platycodon grandiflorus root extract (PGE) has shown various properties, such as anti-hyperlipidemia, anti-diabetic, and anti-obesity, but mostly in animal studies. Therefore, we conducted a preliminary study on the anti-obesity effect of PGE in 108 Korean adults (aged 20–60 years, 30 kg/m2 ≥ body mass index ≥ 23 kg/m2). The participants were randomly assigned to four groups and were administered the placebo, PGE571 (571 mg as PGE), PGE1142 (1142 mg as PGE), and PGE2855 (2855 mg as PGE), independently, for 12 weeks. Body composition, nutrient intake, computed tomography scan, and plasma adipokines, as well as hepatic/renal function markers, were assessed. The PGE571 group revealed a significant decrease in body fat mass and body fat percentage when compared with the placebo group. Moreover, the total abdominal and subcutaneous fat areas were significantly decreased following PGE (PGE2855 group) supplementation. These results provide useful information on the anti-obesity effect of PGE for overweight and obese adult humans. View Full-Text
Keywords: Platycodon grandiflorus root; BMI; body fat mass; abdominal fat area Platycodon grandiflorus root; BMI; body fat mass; abdominal fat area
MDPI and ACS Style

Kim, Y.J.; Kwon, E.-Y.; Kim, J.-W.; Lee, Y.; Ryu, R.; Yun, J.; Kim, M.; Choi, M.-S. Intervention Study on the Efficacy and Safety of Platycodon grandiflorus Ethanol Extract in Overweight or Moderately Obese Adults: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2019, 11, 2445.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop