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Open AccessArticle

Preconception Lifestyle and Cardiovascular Health in the Offspring of Overweight and Obese Women

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Amsterdam UMC, Department of Public and Occupational Health, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1105 AZ Amsterdam, The Netherlands
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Amsterdam UMC, Department of Clinical Epidemiology, University of Amsterdam, Biostatistics and Bioinformatics, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
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Amsterdam UMC, Department of Obstetrics and Gynecology, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
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Amsterdam Public Health Research Institute, 1105 AZ Amsterdam, The Netherlands
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Amsterdam Reproduction and Development, 1105 AZ Amsterdam, The Netherlands
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Division of Human Nutrition, Wageningen University & Research, 6700 AA Wageningen, The Netherlands
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Department of Pediatrics, Emma Children’s Hospital, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands
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Department of Epidemiology, University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, the Netherlands
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Department of Obstetrics and Gynecology, University of Groningen, University Medical Centre, Groningen, 9700 RB Groningen, the Netherlands
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Department of Obstetrics and Gynecology, Monash University, 3800 Melbourne, Australia
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Institute of Sport Science, University of Graz, 8010 Graz, Austria
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Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2446; https://doi.org/10.3390/nu11102446
Received: 11 August 2019 / Revised: 10 October 2019 / Accepted: 11 October 2019 / Published: 14 October 2019
Women’s lifestyle has important implications for the development and health of their offspring. Yet little is known about the association between women’s preconception dietary intake and physical activity with cardiovascular health of the offspring. We therefore examined this association in a group of Dutch women with overweight or obesity (BMI ≥ 29 kg/m2) and infertility, who participated in a 6-month randomized preconception lifestyle intervention trial, and their offspring (n = 46). Preconception dietary intake and physical activity were assessed during the 6-month intervention using a food frequency questionnaire and the Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH), respectively. Offspring cardiovascular health (i.e., BMI, waist:height ratio, systolic and diastolic blood pressure, fat and fat free mass, and pulse wave velocity) was measured at age 3–6 years. Multivariable linear regression analyses were used to examine the associations between preconception lifestyle and offspring cardiovascular health. Higher preconception vegetable intake (per 10 g/day) was associated with lower offspring diastolic blood pressure (Z-score: −0.05 (−0.08; −0.01); p = 0.007) and higher preconception fruit intake (per 10 g/day) was associated with lower offspring pulse wave velocity (−0.05 m/s (−0.10; −0.01); p = 0.03). Against our expectations, higher preconception intake of sugary drinks was associated with a higher offspring fat free mass (0.54 kg (0.01; 1.07); p = 0.045). To conclude, preconception dietary intake is associated with offspring health. View Full-Text
Keywords: preconception dietary intake; preconception physical activity; offspring anthropometry; offspring blood pressure; offspring pulse wave velocity preconception dietary intake; preconception physical activity; offspring anthropometry; offspring blood pressure; offspring pulse wave velocity
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van Elten, T.M.; van de Beek, C.; Geelen, A.; Gemke, R.J.; Groen, H.; Hoek, A.; Mol, B.W.; van Poppel, M.N.; Roseboom, T.J. Preconception Lifestyle and Cardiovascular Health in the Offspring of Overweight and Obese Women. Nutrients 2019, 11, 2446.

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