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Nutrients 2018, 10(12), 1851; https://doi.org/10.3390/nu10121851

Lipidomic Response to Coffee Consumption

1
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 North Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA
2
Genomics and Biomarkers Unit, National Institute for Health and Welfare, P.O. Box 30, 00271 Helsinki, Finland
3
Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany
4
German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany
5
Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
6
Centre for Human Metabolomics, Faculty of Natural Sciences, North-West University (Potchefstroom Campus), Private Bag X6001, Potchefstroom 2520, South Africa
7
Disease Risk Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland
8
Department of Public Health, University of Helsinki, 00014 Helsinki, Finland
9
Saudi Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia
*
Author to whom correspondence should be addressed.
Received: 25 October 2018 / Revised: 7 November 2018 / Accepted: 22 November 2018 / Published: 1 December 2018
(This article belongs to the Special Issue The Impact of Caffeine and Coffee on Human Health)
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Abstract

Coffee is widely consumed and contains many bioactive compounds, any of which may impact pathways related to disease development. Our objective was to identify individual lipid changes in response to coffee drinking. We profiled the lipidome of fasting serum samples collected from a previously reported single blinded, three-stage clinical trial. Forty-seven habitual coffee consumers refrained from drinking coffee for 1 month, consumed 4 cups of coffee/day in the second month and 8 cups/day in the third month. Samples collected after each coffee stage were subject to quantitative lipidomic profiling using ion-mobility spectrometry–mass spectrometry. A total of 853 lipid species mapping to 14 lipid classes were included for univariate analysis. Three lysophosphatidylcholine (LPC) species including LPC (20:4), LPC (22:1) and LPC (22:2), significantly decreased after coffee intake (p < 0.05 and q < 0.05). An additional 72 species mapping to the LPC, free fatty acid, phosphatidylcholine, cholesteryl ester and triacylglycerol classes of lipids were nominally associated with coffee intake (p < 0.05 and q > 0.05); 58 of these decreased after coffee intake. In conclusion, coffee intake leads to lower levels of specific LPC species with potential impacts on glycerophospholipid metabolism more generally. View Full-Text
Keywords: coffee; caffeine; lipids; biomarkers; trial; lysophosphatidylcholine; lipidomics coffee; caffeine; lipids; biomarkers; trial; lysophosphatidylcholine; lipidomics
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Kuang, A.; Erlund, I.; Herder, C.; Westerhuis, J.A.; Tuomilehto, J.; Cornelis, M.C. Lipidomic Response to Coffee Consumption. Nutrients 2018, 10, 1851.

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