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Journal of Xenobiotics, Volume 13, Issue 2

2023 June - 8 articles

Cover Story: Organic anion transporter 1 (OAT1) is an uptake transporter expressed in the basolateral membranes of kidney tubule cells, and it is important for the renal clearance of xenobiotics. In drug development, the in vitro assessment of OAT1 activity is performed, and the kinetic parameters are used for pharmacokinetic predictions. The impact that in vitro incubation time has on the kinetics of OAT1 transport when expressed in Chinese Hamster ovary cells was examined. The maximal rate, Michaelis constant and inhibition potency were sensitive to the incubation time. The use of these incubation-time-sensitive kinetic parameters in downstream modeling led to differences in renal clearance predictions for para-aminohippurate. Incubation time should be considered when extrapolating transport activity from in vitro to in vivo. View this paper
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Articles (8)

  • Article
  • Open Access
3 Citations
3,149 Views
14 Pages

16 June 2023

Embryogenesis is a well-coordinated process relying on precise cues and environmental signals that direct spatiotemporal embryonic patterning. Quite often, when one error in this process occurs, others tend to co-occur. We posit that investigating th...

  • Article
  • Open Access
10 Citations
3,348 Views
14 Pages

Evaluation of Cytotoxicity, Release Behavior and Phytopathogens Control by Mancozeb-Loaded Guar Gum Nanoemulsions for Sustainable Agriculture

  • Ravinder Kumar,
  • Manju Nehra,
  • Dharmender Kumar,
  • Baljeet Singh Saharan,
  • Prince Chawla,
  • Pardeep Kumar Sadh,
  • Anju Manuja and
  • Joginder Singh Duhan

5 June 2023

Chemical fungicides are the backbone of modern agriculture, but an alternative formulation is necessary for sustainable crop production to address human health issues and soil/water environmental pollution. So, a green chemistry approach was used to...

  • Review
  • Open Access
21 Citations
5,068 Views
18 Pages

Microbe-Plant Interactions Targeting Metal Stress: New Dimensions for Bioremediation Applications

  • Baljeet Singh Saharan,
  • Twinkle Chaudhary,
  • Balwan Singh Mandal,
  • Dharmender Kumar,
  • Ravinder Kumar,
  • Pardeep Kumar Sadh and
  • Joginder Singh Duhan

1 June 2023

In the age of industrialization, numerous non-biodegradable pollutants like plastics, HMs, polychlorinated biphenyls, and various agrochemicals are a serious concern. These harmful toxic compounds pose a serious threat to food security because they e...

  • Article
  • Open Access
3 Citations
2,655 Views
15 Pages

Transcriptional Alterations Induced by Delta-9 Tetrahydrocannabinol in the Brain and Gonads of Adult Medaka

  • Marlee Vassall,
  • Sourav Chakraborty,
  • Yashi Feng,
  • Mehwish Faheem,
  • Xuegeng Wang and
  • Ramji Kumar Bhandari

30 May 2023

With the legalization of marijuana smoking in several states of the United States and many other countries for medicinal and recreational use, the possibility of its release into the environment cannot be overruled. Currently, the environmental level...

  • Systematic Review
  • Open Access
30 Citations
26,708 Views
19 Pages

Systematic Review of Safety of Selective Androgen Receptor Modulators in Healthy Adults: Implications for Recreational Users

  • Jonathan D. Vignali,
  • Kevin C. Pak,
  • Holly R. Beverley,
  • Jesse P. DeLuca,
  • John W. Downs,
  • Adrian T. Kress,
  • Brett W. Sadowski and
  • Daniel J. Selig

10 May 2023

Selective Androgen Receptor Modulators (SARMs) are not FDA approved, and obtaining SARMs for personal use is illegal. Nevertheless, SARM use is increasingly popular amongst recreational athletes. Recent case reports of drug-induced liver injury (DILI...

  • Article
  • Open Access
2 Citations
2,989 Views
13 Pages

10 May 2023

Accurate predictions of drug uptake transporter involvement in renal excretion of xenobiotics require determination of in vitro transport kinetic parameters under initial-rate conditions. The purpose of the present study was to determine how changing...

  • Article
  • Open Access
2 Citations
3,810 Views
12 Pages

Correlation of Vitamin 25(OH)D, Liver Enzymes, Potassium, and Oxidative Stress Markers with Lipid Profile and Atheromatic Index: A Pilot Study

  • Stavroula Ioannidou,
  • Konstantina Kazeli,
  • Hristos Ventouris,
  • Dionysia Amanatidou,
  • Argyrios Gkinoudis and
  • Evgenia Lymperaki

1 April 2023

According to recent literature, there is a limited amount of data about the correlation of vitamin 25(OH)D, potassium (K), oxidative stress parameters, and other biomarkers with dyslipidemia, which is an established risk factor for cardiovascular dis...

  • Review
  • Open Access
20 Citations
7,804 Views
21 Pages

25 March 2023

The role of intestinal barrier homeostasis in an individual’s general well-being has been widely addressed by the scientific community. Colorectal cancer is among the illnesses that most affect this biological barrier. While chemotherapy is the...

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J. Xenobiot. - ISSN 2039-4713