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Journal of Xenobiotics, Volume 12, Issue 4

2022 December - 9 articles

Cover Story: Xenobiotics and their metabolism in the human body have been researched for many years already. Especially in pharmacotherapy, there is great interest in gaining knowledge about metabolism and elimination of drugs. Drugs can cause inhibition or induction of the metabolizing enzymes leading to a change in serum concentrations of victim drugs. Therefore, the knowledge of the pharmacokinetic properties of the drugs is important to be able to avoid drug interactions. In recent years, new lessons have been learned: the pharmacogenetic profile of the patients in regard to the liver enzymes has a large impact on pharmacokinetics and drug interactions. With the knowledge of pharmacokinetic profiles of the drugs and the pharmacogenetic profile of the patient, healthcare providers can individualize drug therapy. View this paper
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Articles (9)

  • Review
  • Open Access
29 Citations
7,178 Views
28 Pages

Chemotherapeutic Potential of Saikosaponin D: Experimental Evidence

  • Suryaa Manoharan,
  • Bhuvaneshwari Deivendran and
  • Ekambaram Perumal

17 December 2022

Saikosaponin D (SSD), an active compound derived from the traditional plant Radix bupleuri, showcases potential in disease management owing to its antioxidant, antipyretic, and anti-inflammatory properties. The toxicological effects of SSD mainly inc...

(This article belongs to the Section Natural Products/Herbal Medicines)
  • Communication
  • Open Access
12 Citations
5,778 Views
13 Pages

4 December 2022

The use of antibiotics in ornamental fish is not regulated, as they are not intended for human consumption. Although antibiotic resistant bacteria have been detected in ornamental fish worldwide, there have been no studies to look at the situation in...

  • Article
  • Open Access
9 Citations
3,968 Views
9 Pages

25 November 2022

Brorphine (1-[1-[1-(4-bromophenyl) ethyl]-piperidin-4-yl]-1,3-dihydro-2H-benzo [d]imidazol-2-one) is one of the most recent novel synthetic opioids (NSOs) on the novel psychoactive substances (NPSs) market, involved in over 100 deaths in 2020. Brorph...

(This article belongs to the Topic Environmental Exposure, Biomonitoring and Exposure Assessment)
  • Review
  • Open Access
13 Citations
8,778 Views
12 Pages

Xeno-Estrogenic Pesticides and the Risk of Related Human Cancers

  • Vivek Kumar,
  • Chandra Shekhar Yadav and
  • Basu Dev Banerjee

21 November 2022

In recent decades, “environmental xenobiotic-mediated endocrine disruption”, especially by xeno-estrogens, has gained a lot of interest from toxicologists and environmental researchers. These estrogen-mimicking chemicals are known to caus...

(This article belongs to the Topic Environmental Exposure, Biomonitoring and Exposure Assessment)
  • Article
  • Open Access
7 Citations
3,379 Views
15 Pages

9 November 2022

To control insects, weeds, and infections in crops, old-fashioned pesticide formulations (with massive quantities of heavy metals and a variety of chemicals) are used. By biological amplification via the food chain, many of these established pesticid...

(This article belongs to the Topic Aquatic Emerging Contaminants and Their Ecotoxicological Consequences)
  • Article
  • Open Access
7 Citations
3,290 Views
12 Pages

28 October 2022

Background: The international drug agencies annotate pharmacogenes for many years. Pharmacogenetic testing is thus far only established in few settings, assuming that only few patients are actually affected by drug-gene interactions. Methods: 108 hos...

(This article belongs to the Topic Hazard Assessment of Endocrine Disrupting Chemicals)
  • Article
  • Open Access
6 Citations
4,195 Views
10 Pages

The Effects of Chromium and Vanadium on Biomarkers of Carbohydrate and Lipid Metabolism in Workers Exposed to Coal Fly Ash

  • Lulzim Zeneli,
  • Majlinda Daci-Ajvazi,
  • Ankica Sekovanić,
  • Jasna Jurasović and
  • Demush Bajraktari

19 October 2022

Chromium (Cr) and vanadium (V) are micronutrients playing a role in carbohydrate and lipid metabolism but can be toxic at high concentrations, especially in specific forms. The study documents the effect of Cr and V concentrations on glucose and lipi...

(This article belongs to the Section Ecotoxicology)
  • Review
  • Open Access
24 Citations
8,293 Views
18 Pages

8 October 2022

The highly contagious coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global pandemic and public health emergency as it has taken the lives of over 5.7 million in more than 1...

(This article belongs to the Section Natural Products/Herbal Medicines)
  • Review
  • Open Access
13 Citations
8,957 Views
23 Pages

21 September 2022

Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs) are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with limited short-term efficacy and significant side effects. In this rev...

(This article belongs to the Section Drug Therapeutics)
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J. Xenobiotics - ISSN 2039-4713