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Neurology International, Volume 17, Issue 4

April 2025 - 16 articles

Cover Story: Pain is a complex, multidimensional experience that involves widespread neural networks across the brain. Advances in electroencephalography (EEG), particularly high-density EEG, now enable the capture of fine-grained spatiotemporal dynamics associated with both acute and chronic pain states. These technologies offer unprecedented opportunities to non-invasively monitor cortical activity related to pain perception, modulation, and cognitive–affective processing. This systematic review analyzes the methods of EEG-based pain studies, neural biomarkers, and future directions. The review also addresses commonly seen limitations and suggests strategies towards standardizing approaches for pain data acquisition. View this paper
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Articles (16)

  • Communication
  • Open Access
6 Citations
1,989 Views
14 Pages

Background/Objectives: Burning mouth syndrome (BMS) is a chronic pain disorder of the oral cavity in the absence of organic disease and is prevalent among menopausal women. Estrogen may be involved in the formation of nerves involved in pain. Methods...

  • Article
  • Open Access
1 Citations
1,345 Views
13 Pages

Neonatal Perforator Stroke: Timing, Risk Factors, and Neurological Outcome from a Single-Center Experience

  • Andrea Calandrino,
  • Gaia Cipresso,
  • Marcella Battaglini,
  • Samuele Caruggi,
  • Irene Bonato,
  • Paolo Massirio,
  • Chiara Andreato,
  • Francesco Vinci,
  • Alessandro Parodi and
  • Mariya Malova
  • + 7 authors

Background and purpose: Perforator stroke (PS) is a subtype of perinatal arterial ischemic stroke (PAIS), in which injuries occur in the territory of the perforator branches of the main cerebral arteries. This study aims to explore the incidence, tim...

  • Article
  • Open Access
2,491 Views
9 Pages

Very Early Rehabilitation After Treatment with Intravenous Thrombolysis for Mild Acute Ischemic Stroke

  • Rahul R. Karamchandani,
  • Liang Wang,
  • Dale Strong,
  • Alexis A. Mulvaney,
  • Jonathan D. Clemente and
  • Jeremy B. Rhoten

Background/Objectives: The optimal timing of rehabilitation after acute ischemic stroke is unclear. We studied neurological outcomes and safety of early mobilization (EM) within 24 h for patients receiving intravenous thrombolysis. Methods: This was...

  • Article
  • Open Access
1 Citations
1,171 Views
14 Pages

Background: Working memory (WM) impairment is a potential consequence of motor aphasia resulting from left-hemisphere ischemic stroke. While verbal WM has been studied extensively in this disorder, research regarding non-verbal modalities remains lim...

  • Systematic Review
  • Open Access
3 Citations
2,101 Views
18 Pages

Pathophysiologic Mechanisms of Severe Spinal Cord Injury and Neuroplasticity Following Decompressive Laminectomy and Expansive Duraplasty: A Systematic Review

  • Eleftherios Archavlis,
  • Davide Palombi,
  • Dimitrios Konstantinidis,
  • Mario Carvi y Nievas,
  • Per Trobisch and
  • Irina I. Stoyanova

Background: Severe spinal cord injury (SCI) represents a debilitating condition with long-term physical and socioeconomic impacts. Understanding the pathophysiology of SCI and therapeutic interventions such as decompressive laminectomy and expansive...

  • Perspective
  • Open Access
4 Citations
4,917 Views
11 Pages

Neurofilament Light Chain and Multiple Sclerosis: Building a Neurofoundational Model of Biomarkers and Diagnosis

  • Rany Aburashed,
  • Ansam Eghzawi,
  • Daniel Long,
  • Robert Pace,
  • Ali Madha and
  • Jeanie Cote

Neurofilament light chain (NfL), an abundant cytoskeletal protein in neurons, has emerged as a promising serum biomarker that indicates non-specific neuronal damage secondary to various neurologic diseases, including multiple sclerosis (MS). Emerging...

  • Systematic Review
  • Open Access
3 Citations
1,933 Views
20 Pages

Background/Objectives: Ischemic stroke remains a leading cause of death and disability worldwide. Despite significant progress in reperfusion therapy, the optimal ischemic stroke management strategy has not been developed. Recent studies demonstrate...

  • Brief Report
  • Open Access
732 Views
9 Pages

Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation

  • Njenga R. Kamau,
  • Michelle R. Tamplin,
  • Chu-Yu Lee,
  • Eric D. Axelson,
  • Isabella M. Grumbach and
  • Michael S. Petronek

Background/Objectives: Radiation therapy can often lead to structural and functional changes in the brain resulting in radiation-induced brain injury. This study investigates the MRI-detectable effects of whole-brain irradiation across all neuroanato...

  • Article
  • Open Access
1,461 Views
14 Pages

Linking Memory Impairment to Structural Connectivity in Extrahippocampal Temporal Lobe Epilepsy Surgery

  • Niels Alexander Foit,
  • Karin Gau,
  • Alexander Rau,
  • Horst Urbach,
  • Jürgen Beck and
  • Andreas Schulze-Bonhage

Objective: Temporal lobe epilepsy (TLE) constitutes the most common drug-refractory epilepsy syndrome. Tailored approaches are required, as TLE originates from extrahippocampal lesions in about one-quarter of surgical candidates. Despite high success...

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Neurol. Int. - ISSN 2035-8377