Pharmaceutics, Volume 11, Issue 2 (February 2019) – 50 articles
Cover Story (view full-size image): Dr. Jong Oh Kim and his colleagues created transferrin-conjugated polymeric nanoparticles as doxorubicin carriers to achieve maximum therapeutic efficacy of a chemotherapeutic drug, doxorubicin, in a resistant breast cancer cell line. After an in vitro cellular study, drug resistance was shown to be overcome by an accumulation of doxorubicin in the nuclear region of the cancer cell. In addition, the study showed that doxorubicin-loaded polymeric nanoparticles successfully accumulated with transferrin targeting ligands in xenograft mouse models bearing the doxorubicin-resistant cell line MDA-MB-231(R) with minimum toxicity in healthy organs. View this paper
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