Special Issue "Nose to Brain Delivery"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: 30 November 2018
The blood-brain barrier (BBB) separates the central nervous system (CNS) from general circulation. Drugs targeting the brain represent a remarkable problem, owing to BBB, which does not allow most drugs to pass through it. The use of a nose-to-brain delivery route is an important and noninvasive method of drug delivery to solve this problem and bypass the BBB. Different strategies have been developed to enhance nose-to-brain drug delivery. In fact, it is well-known that an intranasal direct anatomical connection between the nasal cavity and the CNS exists, which suggests the development of nasal formulations for brain targeting of drugs. The design and preparation of nasal formulations involve the development of polymeric pharmaceutical platforms able to interact with nasal mucosa: Bioadhesion and penetration enhancement through nasal mucosa layers are the first and most important characteristics that these systems must have. The development of new nasal systems represents a great challenge in the field of controlled drug targeting and delivery.
This Special Issue has the aim of highlighting current progress in the use of the nasal route for brain targeting.
Prof. Paolo Giunchedi
Prof. Elisabetta Gavini
Prof. Maria Cristina Bonferoni
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Nasal route
- Brain targeting
- Transmucosal delivery
- Penetration enhancers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Tentative Title: Versatile mucohadesive niosomes: a deep physico-chemical characterization
Author: Maria Carafa
Abstract: The aim of this study is to prepare suitable chitosan-glutamate(CG) coated non-ionic surfactant vesicles for intranasal delivery. Different vesicles were prepared using several non-ionic surfactants, cholesterol and chitosan glutamate. The interaction between CG coated niosomes and different mucin concentrations was studied to obtain vesicles with mucoadhesive properties. The size, ζ-potential and pH of the nanocarriers were controlled during the study to be suited for nasal delivery. Furthermore, fluorimetric analysis was carried out to investigate fluidity, microviscosity, polarity of vesicle bilayer and turbidity of CGcoated niosome suspensions. The physical-chemical stability of niosome suspensions were tested at two different storage temperatures, 4ºC and room temperature, following the size and ζ-potential. Additionally, stability studies in artificial biological fluids were carried out. Morphology studies using Atomic Force Microscopy (AFM) was employed for niosomes, CG coated-niosomes and CG coated-niosomes with mucin.
Tentative Title: Nose to Brain Delivery of Polymeric Nanoparticles for Epilepsy Disease: an overview
Authors: Teresa Musumeci1, Angela Bonaccorso and Giovanni Puglisi
Abstract: Epilepsy is the 4th most common neurological problem affecting world population, which can be considered a spectrum disorder because of its several causes, seizure types, its ability to vary in severity and impact from person to person, and its range of co-existing conditions. The approaches to drug therapy of epilepsy are directed at the control of symptoms by chronic administrations of antiepileptic drugs. The AED are administered orally or intravenously but alternative routes of administration are needed to overcome the limits. Intranasal administration represents an attractive route because it is possible to reach the brain bypassing blood brain barrier and the drug avoids first pass metabolism. It is possible to obtain an increase in patient compliance for the easy and non-invasive way of administration. This route shows some drawbacks such as mucociliar clearance and the small volume that could be administrated, in fact only drugs that are efficacy at low doses can be considered. The drug also needs excellent aqueous solubility or must be able to be formulated using solubilizing agents. The use of nanomedicine formulations able to encapsulate active molecules represents a good strategy in order to overcome several limitations of this route and of conventional drug. The aim of this review is to describe the innovative application of nanomedicine for epilepsy treatment using nose to brain delivery.