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Article

Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction

1
Unité de Virologie, Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France
2
Unité Imagerie; Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France
3
Molecular basis of viral pathogenicity, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111—CNRS UMR5308, Université Lyon 1, ENS de Lyon, 69365 LYON CEDEX 07, France
4
Université de Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France
5
Division of Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3512 Utrecht, The Netherlands
6
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(1), 15; https://doi.org/10.3390/v11010015
Received: 30 November 2018 / Revised: 20 December 2018 / Accepted: 22 December 2018 / Published: 26 December 2018
(This article belongs to the Special Issue Emerging Viruses)
Since the largest 2014–2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators. Amongst them, collectins are important players in the antiviral innate immune defense. A screening of Ebola glycoprotein (GP)-collectins interactions revealed the specific interaction of human surfactant protein D (hSP-D), a lectin expressed in lung and liver, two compartments where Ebola was found in vivo. Further analyses have demonstrated an involvement of hSP-D in the enhancement of virus infection in several in vitro models. Similar effects were observed for porcine SP-D (pSP-D). In addition, both hSP-D and pSP-D interacted with Reston virus (RESTV) GP and enhanced pseudoviral infection in pulmonary cells. Thus, our study reveals a novel partner of Ebola GP that may participate to enhance viral spread. View Full-Text
Keywords: surfactant protein; SP-D; Ebola virus; Reston virus; collectin; glycoprotein; interaction; pig; innate immunity surfactant protein; SP-D; Ebola virus; Reston virus; collectin; glycoprotein; interaction; pig; innate immunity
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MDPI and ACS Style

Favier, A.-L.; Reynard, O.; Gout, E.; van Eijk, M.; Haagsman, H.P.; Crouch, E.; Volchkov, V.; Peyrefitte, C.; Thielens, N.M. Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction. Viruses 2019, 11, 15. https://doi.org/10.3390/v11010015

AMA Style

Favier A-L, Reynard O, Gout E, van Eijk M, Haagsman HP, Crouch E, Volchkov V, Peyrefitte C, Thielens NM. Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction. Viruses. 2019; 11(1):15. https://doi.org/10.3390/v11010015

Chicago/Turabian Style

Favier, Anne-Laure; Reynard, Olivier; Gout, Evelyne; van Eijk, Martin; Haagsman, Henk P.; Crouch, Erika; Volchkov, Viktor; Peyrefitte, Christophe; Thielens, Nicole M. 2019. "Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction" Viruses 11, no. 1: 15. https://doi.org/10.3390/v11010015

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