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Laser Fabrication of 3D Gelatin Scaffolds for the Generation of Bioartificial Tissues

1
Department of Nanotechnology, Laser Zentrum Hannover e.V., Hollerithallee 8, D-30419 Hannover, Germany
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Polymer Chemistry & Biomaterials Research Group, University of Ghent, Krijgslaan 281, Building S4-Bis, 9000 Ghent, Belgium
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Department of Cardiac-, Thoraic-, Transplantation-, and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany
*
Author to whom correspondence should be addressed.
Materials 2011, 4(1), 288-299; https://doi.org/10.3390/ma4010288
Received: 1 December 2010 / Revised: 6 January 2011 / Accepted: 12 January 2011 / Published: 19 January 2011
(This article belongs to the Special Issue Tissue Engineering Scaffolds)
In the present work, the two-photon polymerization (2PP) technique was applied to develop precisely defined biodegradable 3D tissue engineering scaffolds. The scaffolds were fabricated via photopolymerization of gelatin modified with methacrylamide moieties. The results indicate that the gelatin derivative (GelMod) preserves its enzymatic degradation capability after photopolymerization. In addition, the developed scaffolds using 2PP support primary adipose-derived stem cell (ASC) adhesion, proliferation and differentiation into the anticipated lineage. View Full-Text
Keywords: scaffolds; computer-aided design; laser fabrication; two-photon polymerization; gelatin; tissue engineering; biodegradation; stem cells; adipose tissue scaffolds; computer-aided design; laser fabrication; two-photon polymerization; gelatin; tissue engineering; biodegradation; stem cells; adipose tissue
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Ovsianikov, A.; Deiwick, A.; Van Vlierberghe, S.; Pflaum, M.; Wilhelmi, M.; Dubruel, P.; Chichkov, B. Laser Fabrication of 3D Gelatin Scaffolds for the Generation of Bioartificial Tissues. Materials 2011, 4, 288-299.

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