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Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA

Department of Nanomaterials in Natural Science, Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 1402/2, 46117 Liberec, Czech Republic
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Materials 2019, 12(19), 3202; https://doi.org/10.3390/ma12193202
Received: 27 August 2019 / Revised: 13 September 2019 / Accepted: 20 September 2019 / Published: 30 September 2019
(This article belongs to the Section Porous Materials)
Our study was focused on the synthesis of selective mesoporous silica nanoparticles (MSNs: MCM-41, MCM-48, SBA-15, PHTS, MCF) that are widely studied for drug delivery. The resulting mesoporous surfaces were conveniently prepared making use of verified synthetic procedures. The MSNs thus obtained were characterized by Brunauer-Emmett-Teller (BET) analysis and scanning electron microscopy (SEM). The selected MSNs with various pore diameters and morphologies were examined to evaluate the capability of L-DOPA drug loading and release. L-DOPA is a well-known drug for Parkinson’s disease. The L-DOPA drug loading and release profiles were measured by UV-VIS spectroscopy and SBA-15 was proved to be the most effective amongst all the different types of tested mesoporous silica materials as L-DOPA drug vehicle. View Full-Text
Keywords: mesoporous silica; nanoparticles; characterisation; electron microscopy; nitrogen adsorption; drug loading and release mesoporous silica; nanoparticles; characterisation; electron microscopy; nitrogen adsorption; drug loading and release
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MDPI and ACS Style

Swar, S.; Máková, V.; Stibor, I. Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA. Materials 2019, 12, 3202. https://doi.org/10.3390/ma12193202

AMA Style

Swar S, Máková V, Stibor I. Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA. Materials. 2019; 12(19):3202. https://doi.org/10.3390/ma12193202

Chicago/Turabian Style

Swar, Sumita, Veronika Máková, and Ivan Stibor. 2019. "Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA" Materials 12, no. 19: 3202. https://doi.org/10.3390/ma12193202

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