2015 October - 29 articles
Palliative care is an approach that focuses on the relief of pain and other symptoms for patients with advanced illnesses and their families, and on maximizing the quality of the patient’s remaining life. [...]
Background: Sarcomas in adults can be associated with hereditary cancer syndromes characterized by early-onset predisposition to numerous types of cancer. Because of variability in familial presentation and the largely unexplained genetic basis of sa...
Background: Fewer than half of all patients with metastatic melanoma survive more than 1 year. Standard treatments have had little success, but recent therapeutic advances offer the potential for an improved prognosis. In the present study, we used p...
Introduction: Stage iii lung cancer is the most advanced stage of lung cancer for which radical (potentially curative) treatment is often discussed. Understanding the reasons for mortality and subsequent treatments in patients with stage iii non-smal...
Background: The quality of data comparing care at the end of life (eol) in cancer patients across Canada is poor. This project used identical cohorts and definitions to evaluate quality indicators for eol care in British Columbia, Alberta, Ontario, a...
Background: We documented changes in practice from 2009 to 2012 for cervical cancer brachytherapy in Canada. Methods: Centres with gynecologic brachytherapy services were sent an e-mail questionnaire querying their 2012 practice. Responses are report...
Background: Access to cancer care is a significant concern for Canadians. Prolonged delays between cancer diagnosis and treatment have been associated with anxiety, stress, and perceived powerlessness for patients and their family members. Longer wai...
Regrettably, some aspects of the breast cancer screening debate display their own uniquely obfuscating argumentation, more smoke and mirrors than scientific clarity. [...]
With so much debate about the value of screening mammography and with the emergence of newer technologies, it seems reasonable to ask whether screening mammography, as we know it, has become obsolete. [...]
Early detection of malignancy through breast cancer screening has contributed significantly to the decline in cancer-related mortality. [...]
Background: The presence of tumour cells in pleural fluid or tissue defines an effusion as malignant. Cytology analysis of the pleural fluid has about 60% diagnostic sensitivity. Several tests have been proposed to improve diagnosis—among them, the c...
Background: Currently in Canada, several bone-targeted agents (BTAS) with varying characteristics are available for the prevention of skeletal-related events (SRES) in patients with bone metastasis secondary to solid tumours. In the present study, we...
Background: Metastatic colorectal cancer (MCRC) commonly affects elderly people, an understudied subset of patients. We analyzed the survival impact of the first and subsequent lines of chemotherapy in eligible non-trial patients 70 years of age and...
Background:Keratoconjunctivitis sicca from chronic graft-versus-host disease (cgvhd) after allogeneic stem cell transplantation is common, leading to severe corneal damage and blindness if not treated. We retrospectively examined the efficacy and saf...
Background: Patient education in early-stage breast cancer has been shown to improve patient well-being and quality of life, but it poses a challenge given the increasingly complex regimens and time constraints in clinical practice. Technology-aided...
Background: We conducted a preliminary retrospective evaluation of the efficacy and toxicity of proton-beam therapy (pbt) for stage iii non-small-cell lung cancer. Methods: Between January 2009 and August 2013, 27 patients (26 men, 1 woman) with stag...
Additional confusion has been added to the “debate” about breast cancer. [...]
Breast cancer screening is a topic of hot debate, and currently no general consensus has been reached on starting and ending ages and screening intervals, in part because of a lack of precise estimations of the benefit–harm ratio. Simulation models a...
Perivascular epithelioid cell tumours (PEComas) are rare mesenchymal tumours that are characterized by perivascular epithelioid cell differentiation and immunoreactivity to myogenic and melanocytic markers. These tumours can be classified as benign,...
Primary intravascular synovial sarcoma is a rare malignancy with only a few cases documented in the literature. On presentation, this tumour usually resembles a deep venous thrombosis (dvt) or pulmonary embolism (pe). Here, we report the case of a 20...
Thymic carcinoma is a rare but lethal mediastinal cancer. The optimal treatment for advanced thymic carcinoma is not yet established. This report is the first known of stereotactic ablative radiotherapy (sabr) with CyberKnife (Accuray, Sunnyvale, CA,...
Kaposi sarcoma (ks) is a vascular tumour caused by oncogenic human herpesvirus type 8; it often occurs with hiv-associated immunosuppression. Numerous cellular signalling pathways are involved in the pathogenesis of ks, among which receptor tyrosine...
Dr. Steven Narod suggests that the increased hazard ratio associated with being in the mammography arm [...]
In his editorial and perspective, Dr. Constantine Kaniklidis covers a lot of ground, and there is much to agree with. Certainly, we should be moving forward to find and evaluate better ways of detecting, characterizing, and treating breast (and other...
I thank Dr. Martin Yaffe for his many constructive comments in his thoughtful review of my previous invited editorial, providing valuable insights into the complex and controversial issues of the current mammography debate. [...]
We read the article “Concurrent chemoradiotherapy for locally advanced breast cancer—time for a new paradigm?” by Mandilaras et al. [...]
Locally advanced breast cancer (labc) represents an advanced stage of heterogenous breast cancers that continues to invoke great interest. [...]
The packed snow yielded its familiar crunch with every step I took. Behind me, the winter daylight faded as darkness crept through the cloudless sky. With each step forward, the brick walls of the cancer centre loomed larger ahead. This was my destin...
Curiosity and apprehension. I experience this tension as a young man ushers me through large daunting doors with “Authorized Personnel Only” posted in bold red letters [...]
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