Current Oncology, Volume 18, Issue 3

The genesis of modern medical oncology dates to the early 1940s, when nitrogen mustard was demonstrated to be useful in the treatment of certain hematologic malignancies [...]

In women with early-stage breast cancer, the use of fec-d (5-fluorouracil–epirubicin–cyclophosphamide followed by docetaxel) has increased, given the increased efficacy of that regimen compared with fec-100 (5-fluorouracil–epirubicin–cyclophosphamide...

The randomized controlled trial (rct) remains the “gold standard” for establishing the efficacy of new medical therapies [...]

Re: Husein–ElAhmed H, Callejas–Rubio JL, Del Olmo RO, Ríos–Fernandez R, Ortego–Centeno N. Severe Raynaud syndrome induced by adjuvant interferon alfa in metastatic melanoma. Curr Oncol 2010;17:122–3. [...]

Background: Despite the positive conclusions of several randomized controlled trials and the publication of national recommendations on colorectal cancer (crc) screening, uptake remained low. The inauguration of the National Colorectal Cancer Screeni...

Background: The efficacy of adjuvant chemotherapy with FEC-D (5-fluorouracil–epirubicin–cyclophosphamide followed by docetaxel) is superior to that with FEC-100 alone in women with early-stage breast cancer. As the use of FEC-D increased in clinical...

Non-small-cell lung cancer (nsclc) has the highest prevalence of all types of lung cancer, which is the second most common cancer and the leading cause of cancer-related mortality in Canada. The need for more effective and less toxic treatment option...

The inaugural Canadian Consortium for LABC (locally advanced breast cancer) conference was held at Langdon Hall, Cambridge, Ontario, April 11–12, 2010. The meeting focused on current and future directions in labc treatment and research, the specific...

We report a recently encountered toxicity of therapy targeting the epidermal growth factor receptor (EGFR) that may be of interest to the wider community of oncologists. [...]

Background: Cancer pain is highly prevalent, and existing treatments are often insufficient to provide adequate relief. Objectives: We assessed the long-term safety and efficacy of subcutaneous tetrodotoxin treatment in reducing the intensity of chro...

O. Harold Warwick graduated in medicine from McGill University as a gold medalist and Rhodes Scholar in 1940. After World War II, he started postgraduate training in Montreal, and in 1946, he began studying the newly described drug treatment of cance...

Recommendation 1: Multidisciplinary Approach: To optimize treatment outcomes, the management of patients with recurrent glioblastoma should be individualized and should involve a multidisciplinary team approach, including neurosurgery, neuropathology...

Aims: Distributed delivery models for cancer care have been introduced to bring care closer to home and to provide better access to cancer patients needing radiotherapy. Very little work has been done to demonstrate the elements critical for success...

With the recent approval by the U.S. Food and Drug Administration of the first therapeutic vaccine for cancer, the long-awaited goal of harnessing a patient’s immune system to attack cancer through this modality is finally realized. However, as resea...

Rosai–Dorfman disease is a rare lymphoproliferative disorder that can have nodal and extranodal manifestations. In the absence of established guidelines for the management of this condition, various therapeutic modalities are used, including radiothe...

It has been 21 years since the first successful use of umbilical cord blood as a source of donor cells for hematopoietic stem cell transplantation (HSCT). Over those years, cord blood transplantation (CBT) has shown marked success as an effective mod...